Treatments for Pseudotumor Cerebri
Treatments for Pseudotumor Cerebri
The list of treatments mentioned in various sources
for Pseudotumor Cerebri
includes the following list.
Always seek professional medical advice about any treatment
or change in treatment plans.
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Discussion of treatments for Pseudotumor Cerebri:
Treatment for pseudotumor cerebri is generally
symptomatic. Pressure may be controlled by removing excess fluid with
repeated spinal taps or by shunting. Steroids may be prescribed to reduce
swelling of brain tissue. Drugs to reduce cerebrospinal fluid production
or hyperosmotic drugs may be used to reduce fluid buildup.
(Source: excerpt from
NINDS Pseudotumor Cerebri Information Page: NINDS)
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Hypertension:
Treatment
(In a Page: Signs and Symptoms)
-
Essential hypertension: Lifestyle changes are the initial interventions unless significant hypertension, end-organ damage, or diabetes is present (smoking cessation; dietary changes, e.g., DASH diet =low in sodium, rich in potassium and calcium; increased exercise)
-
Pharmacologic therapy usually begins with a diuretic or β-blocker (ACE inhibitor in diabetics)
–Diuretics are usually first-line agents, especially in CHF, diabetes, and risk of coronary artery disease
–Use ACE inhibitors in patients with CHF, MI, renal disease, and diabetes
–Use β-blockers in CAD, recent MI, angina, CHF, atrial fibrillation, migraines, hyperthyroidism
–Additional drugs may include angiotensin receptor blockers (especially in patients with cough when using ACE inhibitors), calcium channel blockers, and β-blockers
–Preferred drugs in pregnancy include methyldopa, β-blockers, and vasodilators (do not use ACE/ARBs)
'>
» READ BOOK EXCERPT ONLINE »
Source: In a Page: Signs and Symptoms, 2004
Papilledema:
Treatment
(In a Page: Signs and Symptoms)
-
Pseudotumor cerebri may be self-limited with weight loss, discontinuation of offending medications; diuretics may be used (e.g., acetazolamide) to decrease CSF production, lumboperitoneal shunting or optic nerve sheath decompression may be indicated in some cases
-
Intracranial tumors may require resection
-
Hydrocephalus: Surgical correction of anatomic abnormalities, with or without VP shunt
- Intracranial hemorrhage: Conservative management versus surgical evacuation depends on size and location
–Acute subdural hematoma: Control elevated ICP with osmotic and loop diuretics and mild hyperventilation; emergent craniotomy for evacuation of hematomas that result in significant mass effect
–Epidural hematoma: Usually does not require surgery; hyperventilation and mannitol to decrease ICP
-
Intracerebral infections require appropriate antibiotics
-
Encephalitis: Control ICP by hyperventilation, diuresis
-
Malignant hypertension: Aggressive IV pressure control
» READ BOOK EXCERPT ONLINE »
Source: In a Page: Signs and Symptoms, 2004
Papilledema (Optic Disc Swelling):
Treatment
(In A Page: Pediatric Signs and Symptoms)
-
Condition-dependent: Treatment of underlying systemic disease is often the only treatment
-
Pseudotumor cerebri and other causes of intracranial hypertension: Weight loss, Diamox or Lasix, planned recumbency, LP shunt or optic nerve sheath fenestration if loss of visual function
-
Space-occupying lesion or hemorrhage: Neurosurgical intervention
-
Meningoencephalitis: IV antibiotics
-
Infectious optic neuropathy: Treat underlying cause and consider systemic steroids (controversial)
-
Optic neuritis: IV (not oral) steroids
-
Optic nerve glioma treatment controversial: Observation if slowly progressive, resection if only one nerve involved, radiation if chiasm involved, shunts if increased ICP
-
Toxic or nutritional: Stop offending toxin or supply nutritional supplementation
» READ BOOK EXCERPT ONLINE »
Source: In A Page: Pediatric Signs and Symptoms, 2007
Hypertension:
Treatment
(In A Page: Pediatric Signs and Symptoms)
-
Treat the underlying disease when possible
-
Stop smoking and illicit drug use
-
Avoid the offending drug when possible
-
Limit competitive sports and highly static exercises in patients with severe hypertension only until their BP is controlled and there is no evidence of end organ damage
-
Salt restriction (4–5 g/day), weight loss, and exercise are part of most regimens
-
Essential hypertension can usually be resolved with weight loss, moderate exercise, and dietary modifications
-
For other etiologies, many medications are used to control
blood pressure
–IV: Nicardipine, sodium nitroprusside, labetalol
–Oral: Captopril, enalapril, lisinopril, amlodipine,
nifedipine extended release, propranolol, clonidine, hydralazine
» READ BOOK EXCERPT ONLINE »
Source: In A Page: Pediatric Signs and Symptoms, 2007
Pregnancy-induced hypertension:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Therapy for preeclampsia is designed to halt the disorder’s progress — specifically, the early effects of eclampsia, such as seizures, residual hypertension, and renal shutdown — and to ensure fetal survival. Some physicians advocate the prompt induction of labor, especially if the patient is near term; others follow a more conservative approach. Therapy may include complete bed rest to increase placental perfusion, reduce hypertension, and evaluate response to therapy. Antihypertensive therapy doesn’t alter the potential for developing eclampsia. Diuretics aren’t appropriate during pregnancy.
If the patient’s blood pressure fails to respond to bed rest and sedation and persistently rises above 160/100 mm Hg, or if central nervous system irritability increases, magnesium sulfate may produce general sedation, promote diuresis, and prevent seizures. Cesarean birth or oxytocin induction may be required to terminate the pregnancy.
Emergency treatment of eclamptic seizures consists of immediate administration of magnesium sulfate (I.V. drip), oxygen administration, and electronic fetal monitoring. After the seizures subside and the patient’s condition stabilizes, delivery should proceed with induction of labor or cesarean birth, depending upon the circumstances.
Adequate nutrition, good prenatal care, and control of pre-existing hypertension during pregnancy decrease the incidence and severity of preeclampsia. Early recognition and prompt treatment of preeclampsia can prevent progression to eclampsia.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Hypertensive crisis:
Treatment (Tx)
(Professional Guide to Diseases (Eighth Edition))
Nitroprusside, nitroglycerin, diazoxide, hydralazine, methyldopa
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Pulmonary hypertension:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Treatment usually includes oxygen therapy to decrease hypoxemia and resulting pulmonary vascular resistance. It may also include vasodilator therapy (nifedipine, diltiazem, or prostaglandin E). For patients with right-sided heart failure, treatment also includes fluid restriction, cardiac glycosides to increase cardiac output, and diuretics to decrease intravascular volume and extravascular fluid accumulation. Treatment also aims to correct the underlying cause.
Some patients with pulmonary hypertension may be candidates for heart-lung transplantation to improve their chances of survival.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Malignant brain tumors:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Treatment includes removing a resectable tumor; reducing a nonresectable tumor; relieving cerebral edema, increased ICP, and other symptoms; and preventing further neurologic damage.
The mode of therapy depends on the tumor's histologic type, radiosensitivity, and location and may include surgery, radiation, chemotherapy, or decompression of increased ICP with diuretics, cortico-steroids, or possibly ventriculoatrial or ventriculoperitoneal shunting of CSF.
A glioma usually requires resection by craniotomy, followed by radiation therapy and chemotherapy. The combination of nitrosoureas (carmustine [BCNU], lomustine [CCNU], or procarbazine) and postoperative radiation is more effective than radiation alone.
Surgical resection of low-grade cystic cerebellar astrocytomas brings long-term survival. Treatment of other astrocytomas includes repeated surgery, radiation therapy, and shunting of fluid from obstructed CSF pathways. Some astrocytomas are highly radiosensitive, but others are radioresistant.
Treatment of oligodendrogliomas and ependymomas includes resection and radiation therapy; for medulloblastomas, resection and possibly intrathecal infusion of methotrexate or another antineoplastic drug. Meningiomas require resection, including dura mater and bone (operative mortality may reach 10% because of large tumor size).
For schwannomas, microsurgical technique allows complete resection of the tumor and preservation of facial nerves. Although schwannomas are moderately radioresistant, postoperative radiation therapy is necessary.
Chemotherapy for malignant brain tumors includes the nitrosoureas that help break down the blood-brain barrier and allow other chemotherapeutic drugs to go through as well. Intrathecal and intra-arterial administration of drugs maximizes drug actions.
Palliative measures for gliomas, astrocytomas, oligodendrogliomas, and ependymomas include dexamethasone for cerebral edema; osmotic diuretics, such as urea and mannitol, to reduce brain swelling; analgesics to control pain; and antacids and histamine receptor antagonists for stress ulcers. These tumors and schwannomas may also require anticonvulsants such as phenytoin to reduce seizures.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Renovascular hypertension:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Surgery, the treatment of choice, is performed to restore adequate circulation and to control severe hypertension or severely impaired renal function by renal artery bypass, endarterectomy, arterioplasty or, as a last resort, nephrectomy. Balloon catheter renal artery dilation is used in selected cases to correct renal artery stenosis without the risks and morbidity of surgery. Symptomatic measures include antihypertensives, diuretics, and a sodium-restricted diet.
Medications that may be used in an attempt to control blood pressure include diuretics, beta-adrenergic blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, and alpha-adrenergic blockers. Diazoxide or nitroprusside may be given in the hospital if symptoms are acute. Response to medications is highly individual and the dosage or specific drug used may need frequent adjustment.
Lifestyle changes may be recommended, including weight, exercise, dietary adjustments, smoking cessation, and avoidance of alcohol. These habits add to the effects of hypertension in causing complications.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Hydrocephalus:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Surgical correction is the only treatment for hydrocephalus. Surgery typically consists of insertion of a ventriculoperitoneal shunt, which transports excess fluid from the lateral ventricle into the peritoneal cavity. A less common procedure is insertion of a ventriculoatrial shunt, which drains fluid from the brain’s lateral ventricle into the right atrium of the heart, where the fluid makes its way into the venous circulation.
Complications of surgery include shunt infection, septicemia (after ventriculoatrial shunt), adhesions and paralytic ileus, migration, peritonitis, and intestinal perforation (with peritoneal shunt).
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Hypertension:
Treatment
(Professional Guide to Diseases (Eighth Edition))
The National Institutes of Health recommend the following approach for treating primary hypertension:
❑ First, help the patient initiate necessary lifestyle modifications, including weight reduction, moderation of alcohol intake, regular physical exercise, reduction of sodium intake, and smoking cessation.
❑ If the patient fails to achieve the desired blood pressure or make significant progress, continue lifestyle modifications and begin drug therapy.
❑ For stage 1 hypertension (systolic [SBP] blood pressure 140 to 159 mm Hg, or diastolic blood pressure [DBP] 90 to 99 mm Hg) in the absence of compelling indications (heart failure, postmyocardial infarction, high coronary disease risk, diabetes, chronic kidney disease, or recurrent stroke prevention), give most patients thiazide-type diuretics. Consider using an angiotensin-converting enzyme (ACE) inhibitor, beta-adrenergic blocker, calcium channel blocker (CCB), angiotensin-receptor blocker (ARB), or a combination.
❑ For stage 2 hypertension (SBP ≥ 160 mm Hg, or DBP ≥ 100 mm Hg) in the absence of compelling indications, give most patients a two-drug combination (usually a thiazide-type diuretic and an ACE inhibitor, ARB, CCB, or beta-adrenergic blocker).
❑ If the patient has one or more compelling indications, base drug treatment on benefits from outcome studies or existing clinical guidelines. Treatment may include the following, depending on indication:
– Heart failure — diuretic, beta-adrenergic blocker, ACE inhibitor, ARB, or aldosterone antagonist
– High coronary disease risk — diuretic, beta-adrenergic blocker, ACE inhibitor, or CCB
– Diabetes — diuretic, beta-adrenergic blocker, ACE inhibitor, or CCB
– Chronic kidney disease — ACE inhibitor or ARB
– Postmyocardial failure — ACE inhibitor, beta-adrenergic blocker, or aldosterone antagonist
– Recurrent stroke prevention — diuretic or ACE inhibitor.
Give other antihypertensive drugs as needed.
❑ If the patient fails to achieve the desired blood pressure, continue lifestyle modifications and optimize drug dosages or add additional drugs until the goal blood pressure is achieved. Also, consider consultation with a hypertension specialist.
Treatment of secondary hypertension focuses on correcting the underlying cause and controlling hypertensive effects.
Typically, hypertensive emergencies require parenteral administration of a vasodilator or an adrenergic inhibitor or oral administration of a selected drug, such as nifedipine, captopril, clonidine, or labetalol, to rapidly reduce blood pressure. The initial goal is to reduce mean arterial blood pressure by no more than 25% (within minutes to hours) then to 160/110 within 2 hours while avoiding excessive falls in blood pressure that can precipitate renal, cerebral, or myocardial ischemia.
Examples of hypertensive emergencies include hypertensive encephalopathy, intracranial hemorrhage, acute left-sided heart failure with pulmonary edema, and dissecting aortic aneurysm. Hypertensive emergencies are also associated with eclampsia or severe gestational hypertension, unstable angina, and acute myocardial infarction.
Hypertension without accompanying symptoms or target-organ disease seldom requires emergency drug therapy.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Blood pressure increase [Hypertension]:
Patient counseling
(Professional Guide to Signs & Symptoms (Fifth Edition))
Encourage the patient to lose weight, if necessary, and to restrict sodium intake. Suggest that he participate in an exercise or stress management program as well. Then teach the patient how to monitor his blood pressure so that he can evaluate the effectiveness of drug therapy and lifestyle changes. Have him record blood pressure readings and symptoms, and ask him to share this information on his return visits.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Signs & Symptoms (Fifth Edition), 2006
Hypertension, pregnancy-induced:
Treatment
(Handbook of Diseases)
Adequate nutrition, good prenatal care, and control of preexisting hypertension with hydralazine during pregnancy decrease the incidence and severity of preeclampsia. Early recognition and prompt treatment of preeclampsia can prevent progression to eclampsia.
Therapy for preeclampsia is designed to halt the disorder’s progress — specifically, the early effects of eclampsia, such as seizures, residual hypertension, and renal shutdown — and to ensure fetal survival. Some physicians advocate the prompt induction of labor, especially if the patient is near term; others follow a more conservative approach.
Conservative measures
Therapy may include sedatives, such as phenobarbital, along with complete bed rest to relieve anxiety, reduce hypertension, and evaluate response to therapy. If renal function remains adequate, a high-protein, low-sodium, low-carbohydrate diet with increased fluid intake is recommended.
If blood pressure fails to respond to bed rest and sedation and persistently rises above 160/100 mm Hg or if CNS irritability increases, magnesium sulfate may produce general sedation, promote diuresis, reduce blood pressure, and prevent seizures.
Cesarean delivery
If these measures fail to improve the patient’s condition or if fetal life is endangered (as determined by stress or nonstress tests), cesarean delivery or oxytocin induction may be required to terminate the pregnancy.
Treatment for seizures
Emergency treatment of eclamptic seizures consists of immediate administration of I.V. diazepam, followed by magnesium sulfate (I.V. drip), oxygen administration, and electronic fetal monitoring. After the patient’s condition stabilizes, a cesarean delivery may be performed.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Pulmonary hypertension:
Treatment
(Handbook of Diseases)
Appropriate treatment usually includes oxygen therapy to decrease hypoxemia and resulting pulmonary vascular resistance. For patients with right-sided heart failure, treatment also includes fluid restriction, cardiac glycosides to increase cardiac output, and diuretics to decrease intravascular volume and extravascular fluid accumulation. An important goal of treatment is correction of the underlying cause.
CLINICAL TIP: Patients with primary pulmonary hypertension usually respond to epoprostenol (PGI2) as a continuous home infusion.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Brain tumors, malignant:
Treatment
(Handbook of Diseases)
Remedial approaches include removing a resectable tumor; reducing a nonresectable tumor; relieving cerebral edema, increased ICP, and other signs and symptoms; and preventing further neurologic damage.
The mode of therapy depends on the tumor’s histologic type, radiosensitivity, and location and may include surgery, radiation, chemotherapy, or decompression of increased ICP with a diuretic, corticosteroid or, possibly, ventriculoatrial or ventriculoperitoneal shunting of CSF.
❑ Gliomas. Treatment usually requires resection by craniotomy, followed by radiation therapy and chemotherapy. The combination of nitrosoureas (carmustine [BCNU], lomustine [CCNU], or procarbazine) and postoperative radiation is more effective than radiation alone.
❑ Astrocytomas. Surgical resection of low-grade cystic cerebellar astrocytomas brings long-term survival. Treatment of other astrocytomas includes repeated surgery, radiation therapy, and shunting of fluid from obstructed CSF pathways. Some astrocytomas are highly radiosensitive, but others are radioresistant.
❑ Oligodendrogliomas and ependymomas. Treatment includes resection and radiation therapy.
❑ Medulloblastomas. Treatment involves resection and, possibly, intrathecal infusion of methotrexate or another antineoplastic.
❑ Meningiomas. Treatment requires resection, including dura mater and bone (operative mortality may reach 10% because of large tumor size).
❑ Schwannomas. Microsurgical technique allows complete resection of the tumor and preservation of facial nerves. Although schwannomas are moderately radioresistant, postoperative radiation therapy is necessary.
Chemotherapy for malignant brain tumors includes a nitrosourea to help break down the blood-brain barrier and permit other chemotherapeutic drugs to go through as well. Intrathecal and intra-arterial administration of drugs maximizes drug action.
Palliative measures for gliomas, astrocytomas, oligodendrogliomas, and ependymomas include dexamethasone for cerebral edema and an antacid and a histamine-receptor antagonist for stress ulcers. These tumors and schwannomas may also require an anticonvulsant.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Hydrocephalus:
Treatment
(Handbook of Diseases)
Surgical correction is the only treatment for hydrocephalus. Usually, such surgery consists of insertion of a ventriculoperitoneal shunt, which transports excess fluid from the lateral ventricle into the peritoneal cavity.
A less common procedure is insertion of a ventriculoatrial shunt, which drains fluid from the brain’s lateral ventricle into the right atrium of the heart, where the fluid makes its way into the venous circulation. Endoscopic third ventriculostomy (ETV) involves creating a passage between the third ventricle and the basal cisterns. This procedure is used for noncommunicating hydrocephalus in patients over age 2.
Complications of surgery include shunt infection, septicemia (after ventriculoatrial shunt), adhesions and paralytic ileus, migration, peritonitis, and intestinal perforation (with peritoneal shunt).
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Hypertension:
Treatment
(Handbook of Diseases)
Secondary hypertension treatment focuses on correcting the underlying cause and controlling hypertensive effects.
The National Institutes of Health recommend the following approach for treating primary hypertension:
❑ First, help the patient initiate necessary lifestyle modifications, including weight reduction, moderation of alcohol intake, regular physical exercise, reduction of sodium intake, and smoking cessation.
❑ If the patient fails to achieve the desired blood pressure or make significant progress, continue lifestyle modifications and begin drug therapy.
❑ For stage 1 hypertension (systolic [SBP] blood pressure 140 to 159 mm Hg, or diastolic blood pressure [DBP] 90 to 99 mm Hg) in the absence of compelling indications (heart failure, postmyocardial infarction, high coronary disease risk, diabetes, chronic kidney disease, or recurrent stroke prevention), give most patients thiazide-type diuretics. Consider using an angioten-sin converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), beta-adrenergic blocker (BB), calcium channel blocker (CCB), or a combination.
❑ For stage 2 hypertension (SBP ≥ 60 mm Hg, or DBP ≥ 100 mm Hg) in the absence of compelling indications, give most patients a two-drug combination (usually a thiazide-type diuretic and an ACEI, ARB, BB, or CCB).
❑ If the patient has one or more compelling indications, base drug treatment on benefits from outcome studies or existing clinical guidelines. Treatment may include the following, depending on indication:
❑ Heart failure — diuretic, BB, ACEI, ARB, or aldosterone antagonist
❑ Post myocardial infarction — BB, ACEI, or aldosterone antagonist
❑ High coronary disease risk — diuretic, BB, ACEI, or CCB
❑ Diabetes — diuretic, BB, ACEI, ARB, or CCB
❑ Chronic kidney disease — ACEI or ARB
❑ Recurrent stroke prevention — diuretic or ACEI.
Give other antihypertensive drugs as needed.
❑ If the patient fails to achieve the desired blood pressure, continue lifestyle modifications and optimize drug dosages or add additional drugs until the goal blood pressure is achieved. Also, consider consultation with a hypertension specialist.
UNDER STUDY: Studies have shown that omega-3 fatty acids used in the treatment of hypertension significantly reduce total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels and lower systolic and diastolic blood pressure.
Clinical tip The treatment for renal artery stenosis includes the use of ACE inhibitors and renal artery stents.
Hypertensive emergencies
Examples of hypertensive emergencies include hypertensive encephalopathy, intracranial hemorrhage, acute left-sided heart failure with pulmonary edema, and dissecting aortic aneurysm. Hypertensive emergencies are also associated with eclampsia and severe pregnancy-induced hypertension, unstable angina, and acute MI.
Typically, hypertensive emergencies require parenteral administration of a vasodilator or an adrenergic inhibitor or oral administration of a selected drug, such as nifedipine, captopril, clonidine, or labetalol, to rapidly reduce blood pressure.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Blood pressure, increased [Hypertension]:
Nursing considerations
(Nursing: Interpreting Signs and Symptoms)
▪ If routine screening detects elevated blood pressure, prepare the patient for routine blood tests, urinalysis, and depending on the suspected cause of the increased blood pressure, radiographic studies, especially of the kidneys.
▪ Administer antihypertensives, as ordered, and evaluate their effect.
Patient teaching
▪ Explain the importance of regular blood pressure monitoring and keeping follow-up appointments.
▪ Explain how to take prescribed antihypertensives correctly and adverse effects that should be reported.
▪ Instruct the patient not to discontinue medications without contacting the practitioner.
▪ Emphasize the importance of weight loss and regular exercise.
▪ Explain the need for sodium restriction.
▪ Discuss stress management.
▪ Discuss ways of reducing other risk factors for coronary artery disease, such as smoking cessation and lowering elevated cholesterol levels.
» READ BOOK EXCERPT ONLINE »
Source: Nursing: Interpreting Signs and Symptoms, 2007
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