Cure Research for Psoriatic Arthritis

Treatments for Psoriatic Arthritis

Treatments to consider for Psoriatic Arthritis may include:

• Treatments are directed at reducing and controlling inflammation. NSAIDs such as diclofenac and naproxen are usually the first line medication
• Other treatment options for this disease include joint injections with corticosteroids
• Immunosuppressants such as methotrexate or leflunomide
• Tumor necrosis factor-alpha inhibitors
• more treatments...»

Medical Research Breakthroughs and Psoriatic Arthritis

New Genetic possibilities in Psoriasis: Psoriasis is an autoimmune disease wherein the skin is attacked by ones own immune system. Patients with psoriasis commonly develop psoriatic arthritis which is a painful and debilitating arthritic condition additionally characterized by pitting or complete loss of fingernails. Many factors are involved in this condition and is very complex at the genetic level. Research has shown that a few but common DNA differences are important in the development of psoriasis. Although each variation makes only a small contribution to the disease, patients usually have a number of different genetic variations that increases their risk of psoriasis and psoriatic arthritis. Recent new studies have shown that seven new sites of common DNA variation have been discovered that increase the risk of psoriasis. Some of these variations, in one area of the genome, link psoriasis and psoriatic arthritis to other autoimmune disorders. The study showed that the DNA variations that were located on chromosome 4 were strongly linked to psoriatic arthritis. These variations were also associated with type 1 diabetes, rheumatoid arthritis, Grave's disease and celiac disease.These variations convey that different biological pathways could be responsible for psoriasis on a basic level. This study may lead to new targeted drugs and treatments that attack specific pathways.

Psoriatic Arthritis Treatment: Book Excerpts

• Treatment - Arthritis – Single Joint
• Treatment - Osteoarthritis
• Treatment - Psoriatic arthritis
• Treatment - Septic arthritis
• Treatment - Psoriasis
• Treatment - Osteoarthritis
• Treatment - Psoriatic arthritis
• Treatment - Septic arthritis
• Treatment - Psoriasis

Clinical Trials for Psoriatic Arthritis

Some of the clinical trials for Psoriatic Arthritis include:

• Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions - This study has been completed (Current: 23 Nov 2006)
• A Controlled Trial of Intermittent Fludarabine for Psoriatic Arthritis - This study has been completed (Current: 23 Nov 2006)
• REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Enbrel - This study is currently recruiting patients (Current: 23 Nov 2006) - Enbrel®
• hOKT3gamma1 (Ala-Ala) for the Treatment of Psoriatic Arthritis - This study is currently recruiting patients (Current: 23 Nov 2006) - hOKT3gamma1 (Ala-Ala)
• A Study of the Safety and Efficacy of Golimumab in Patients With Active Psoriatic Arthritis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Golimumab (CNTO 148)
• more trials...»

Evidence Based Medicine Research for Psoriatic Arthritis

Medical research papers related to Psoriatic Arthritis include:

• Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial.
• Alefacept with methotrexate for treatment of psoriatic arthritis: open-label extension of a randomized, double-blind, placebo-controlled study
• Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: A population-based study
• Risk of herpes zoster in patients with rheumatoid arthritis treated with anti-TNF-alpha agents.
• Guidelines of care for the management of psoriasis and psoriatic arthritis: section 2. psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics.
• Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics.
• A systematic review and meta-analysis of efficacy and toxicity of disease modifying anti-rheumatic drugs and biological agents for psoriatic arthritis
• Risks and Benefits of Tumor Necrosis Factor-a Inhibitors in the Management of Psoriatic Arthritis: Systematic Review and Metaanalysis of Randomized Controlled Trials
• Psoriatic Arthritis
• Magnetic resonance imaging and bone scintigraphy in the differential diagnosis of unclassified arthritis
• Adalimumab for the treatment of psoriasis
• Adalimumab - Psoriasis
• To test or not to test? An evidence-based assessment of the value of screening and monitoring tests when using systemic biologic agents to treat psoriasis
• Etanercept (Enbrel) Psoriasis ? moderate-to-severe in children and adolescents
• Management of sexually-acquired reactive arthritis
• Adalimumab for the treatment of psoriatic arthritis
• Golimumab (CNTO 148) Psoriatic arthritis ? DMARD resistant
• Psoriasis and Psoriatic Arthritis
• Adalimumab improves joint-related and skin-related functional impairment in patients with psoriatic arthritis: patient-reported outcomes of the Adalimumab Effectiveness in Psoriatic Arthritis Trial.
• Adalimumab for the treatment of psoriatic arthritis.
• The cost-effectiveness of etanercept and infliximab for the treatment of patients with psoriatic arthritis.
• Safety and efficacy of adalimumab in treatment of patients with psoriatic arthritis who had failed disease modifying antirheumatic drug therapy.
• Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: A double-blind, placebo-controlled study.
• Effect of infliximab therapy on employment, time lost from work, and productivity in patients with psoriatic arthritis.
• Psoriatic arthritis
• Pathogenesis and clinical features of psoriasis.
• Acne therapy: a letter from America
• Acne therapy from the patient's perspective
• Oral minocycline and acne
• Challenges in the treatment of acne: a primary care perspective

Click here to find more evidence-based articles on the TRIP Database

 » Next page: Statistics about Psoriatic Arthritis

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