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Clinical Trials for Pulmonary hypertension
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Pulmonary hypertension is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Pulmonary hypertension:
- Sildenafil Study to Treat Idiopathic Pulmonary Fibrosis - This study is currently recruiting patients (Current: 23 Nov 2006) - sildenafil
- Sildenafil to Increase Exercise Capacity in Individuals With Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil (50 mg)
- Phase IV Study of Chronic Infusional Epoprostenol for Severe Primary Pulmonary Hypertension - This study has been completed (Current: 23 Nov 2006) - epoprostenol
- Study of Inhaled Nitric Oxide for Preterm Infants - This study is no longer recruiting patients (Current: 23 Nov 2006) - inhaled nitric oxide
- Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide/INP Pulse Delivery,Nitric Oxide/INO Pulse Delivery
- Iloprost-Study: Comparison of Nitric Oxide to Iloprost (Ventavis) for Treatment of Pulmonary Hypertension in Children After Cardiopulmonary Bypass Surgery - This study is currently recruiting patients (Current: 23 Nov 2006) - aerosolized iloprost
- Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) - This study is currently recruiting patients (Current: 23 Nov 2006) - bosentan
- PHIRST-1: Tadalafil in the Treatment of Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - tadalafil
- Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide
- Natrecor in Pulmonary Hypertension - This study has been terminated (Current: 23 Nov 2006) - Nesiritide (Natrecor)
- Heart Disease in Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
- Sildenafil and Pulmonary Artery Pressure - This study is currently recruiting patients (Current: 23 Nov 2006) - sildenafil
- Simvastatin as a Treatment for Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Simvastatin
- Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Erythropoietin and Hydroxyurea
- Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH) - This study is currently recruiting patients (Current: 23 Nov 2006) - bosentan
- Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH) - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
- Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH) - This study is currently recruiting patients (Current: 23 Nov 2006) - bosentan
- Dose Determination Safety and Activity Study of Inhaled NX1011 to Treat Pulmonary Arterial Hypertension - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - NX1011
- Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery? - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil (Viagra)
- Safety and Effectiveness of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - PRX-08066
- Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
- Safety, Efficacy and Treatment Satisfaction in Patients With Pulmonary Arterial Hypertension Rapidly Switched From Epoprostenol to Remodulin - This study is currently recruiting patients (Current: 23 Nov 2006) - treprostinil sodium
- Placebo Controlled Trial of Bosentan in Scleroderma Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
- Multi-Center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
- Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - UT-15
- Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death - This study has been completed (Current: 23 Nov 2006)
- Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of BSF 208075 Evaluating Exercise Capacity in Patients With Pulmonary Arterial Hypertension - This study is no longer recruiting patients (Current: 23 Nov 2006) - BSF 208075
- NO Need to Ventilate: A Trial of Non-Invasive Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn - This study is currently recruiting patients (Current: 23 Nov 2006) - iNO
- Inhaled Prostacyclin for ARDS and Pulmonary Hypertension - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - alprostadil nebulised via endotracheal tube
- Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006) - Pamidronate,Ribavirin,Deferoxamine,Deferiprone,Arginine
- Pulmonary Hypertension--Mechanisms and Family Registry - This study has been completed (Current: 23 Nov 2006)
- Early Inhaled Nitric Oxide for Respiratory Failure in Newborns - This study has been completed (Current: 23 Nov 2006) - Inhaled Nitric Oxide
- Inhaled Nitric Oxide Study for Respiratory Failure in Newborns - This study has been terminated (Current: 23 Nov 2006) - Inhaled nitric oxide
- The Effect of Tracleer on Male Fertility - This study is currently recruiting patients (Current: 23 Nov 2006) - Tracleer® (bosentan)
- Genetic and Environmental Characteristics of Primary Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
- Endothelial Cell Dysfunction in Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide/INO Pulse Delivery,Sodium Nitrite,Nitric Oxide
- A Study of Aspirin and Clopidogrel in Patients With Idiopathic Pulmonary Arterial Hypertension - This study has been completed (Current: 23 Nov 2006) - Aspirin,clopidogrel
- Chronic Sildenafil for Severe Diaphragmatic Hernia - This study is currently recruiting patients (Current: 23 Nov 2006) - sildenafil
- Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension - This study has been completed (Current: 23 Nov 2006) - spironolactone captopril carvedilol
- Bosentan to Treat Pulmonary Arterial Hypertension in Sickle Cell Disease (Asset 1 Study) - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
- Bosentan to Treat Pulmonary Hypertension in Sickle Cell Disease (Asset 2 Study) - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
- Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery - This study is currently recruiting patients (Current: 23 Nov 2006) - L-citrulline
- A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Aspirin,Simvastatin
- Evaluation of Patients With Known or Suspected Heart Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- Safety and Efficacy of Sitaxsentan in the Treatment of Pulmonary Arterial Hypertension - This study is no longer recruiting patients (Current: 23 Nov 2006) - sitaxsentan sodium
- Development of a Hospital-Based Home Program for the Use of Inhaled Nitric Oxide in the Chronic Management of Severe Cardiopulmonary Diseases - This study is currently recruiting patients (Current: 23 Nov 2006) - INOmax (nitric oxide for inhalation)
- A Transition Study From Flolan to Remodulin in Patients With Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - treprostinil sodium
- Safety and Efficacy Study of Sitaxentan Sodium (Thelin) in Patients With Pulmonary Arterial Hypertension - This study has been completed (Current: 23 Nov 2006) - sitaxsentan sodium
- Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hypertension (PAH) - This study has been completed (Current: 23 Nov 2006) - Iloprost or placebo
- ARIES - Ambrisentan in Patients With Moderate to Severe Pulmonary Arterial Hypertension (PAH) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Ambrisentan
- Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II - This study has been completed (Current: 23 Nov 2006) - bosentan
- Inhaled Iloprost in Adults With Abnormal Pulmonary Pressure and Associated With Idiopathic Pulmonary Fibrosis - This study is currently recruiting patients (Current: 23 Nov 2006) - Iloprost Inhalation Solution (Ventavis)
- Clinical Investigation Into the Efficacy and Tolerability of Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH) - This study is currently recruiting patients (Current: 23 Nov 2006) - Inhaled Treprostinil Sodium
- Open Label Extension Study Evaluating Sildenafil Citrate When Used In Combination With Epoprostenol In PAH - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil citrate
- The Efficacy and Safety of Sildenafil Citrate Used in Combination With Intravenous Epoprostenol in PAH - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil citrate
- Long Term Extension Study Evaluating Safety of Sildenafil Citrate When Used to Treat PAH in Children - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil citrate
- Study to Assess the Longterm Safety of Sildenafil Citrate in Patients With Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil citrate
- A Randomized, Double-Blind, Placebo-Controlled Study of Sildenafil in Children With Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil citrate
- Genetic Research of Bone Morphogenetic Protein Receptor-II Gene in Taiwanese Patient With Primary Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
- Safety Follow-Up Study of Inhaled Iloprost in Patients With Pulmonary. Hypertension - This study has been completed (Current: 23 Nov 2006) - Inhaled iloprost
- The VISION Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Iloprost Inhalation Solution (Ventavis)
- Bosentan in Children With Pulmonary Arterial Hypertension Extension Study - This study is currently recruiting patients (Current: 23 Nov 2006) - bosentan
- Bosentan in Children With Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - bosentan
- Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension (PAH) - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Sildenafil Citrate
- FREEDOM - M: Oral Treprostinil as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH) - This study is currently recruiting patients (Current: 23 Nov 2006) - Oral treprostinil (UT-15C) Sustained Release Tablets
- FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH) - This study is currently recruiting patients (Current: 23 Nov 2006) - Oral treprostinil (UT-15C) Sustained Release Tablets
- A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Study - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
- Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria - This study is currently recruiting patients (Current: 23 Nov 2006)
- REVEAL Registry: Registry to Evaluate Early And Long-Term PAH Disease Management - This study is currently recruiting patients (Current: 23 Nov 2006)
- Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Ambrisentan
- Long-Term Observational Study of Ventavis in Pulmonary Hypertension. - This study is currently recruiting patients (Current: 23 Nov 2006) - Ventavis
- Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - bosentan
- Gene Mutations in Secondary Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
- Efficacy of Type-5 Phosphodiesterase Inhibitors in Primary and Secondary Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - type-5 phosphodiesterase Inhibitor (Sildenafil)
- Serotonin Transporter Inhibitor Escitalopram in Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - escitalopram
- Treatment of Elevated Arterial Pulmonary Pressure With Inhaled Iloprost. - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - iloprost
- Natrecor for Pulmonary Hypertension in Lung Transplants - This study is currently recruiting patients (Current: 23 Nov 2006) - Natrecor
- Sildenafil to Treat HIV-Associated Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
- Epidemiology of Persistent Pulmonary Hypertension of the Newborn - SCOR in Lung Biology and Diseases in Infants and Children - This study has been completed (Current: 23 Nov 2006)
- Risk Factors for Pulmonary Hypertension of the Newborn - This study has been completed (Current: 23 Nov 2006)
- Antibody Secreting Cell and Cyotkine Profiles in Neonates on ECMO - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Bosentan in Treatment of Pulmonary Arterial Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan administration
- Natural History of Sickle Cell Disease and Other Hemolytic Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
- Evaluation of Patients With Critical Illness - This study is currently recruiting patients (Current: 23 Nov 2006)
- Pulmonary Arteriopathy-Diagnostics and Therapy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study Protocol Evaluating Transient Tachypnoea of the Newborn in Term and Near Term Neonates - This study is currently recruiting patients (Current: 23 Nov 2006)
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Pulmonary hypertension:
The trial data on this page has been sourced from
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