The follow list shows some of the possible medical causes of Rhabdomyolysis that are listed by the Diseases Database:
Other conditions that might have Rhabdomyolysis as a complication may, potentially, be an underlying cause of Rhabdomyolysis. Our database lists the following as having Rhabdomyolysis as a complication of that condition:
Conditions listing Rhabdomyolysis as a symptom may also be potential underlying causes of Rhabdomyolysis. Our database lists the following as having Rhabdomyolysis as a symptom of that condition:
The following drugs, medications, substances or toxins are some of the possible
causes of Rhabdomyolysis as a symptom.
This list is incomplete and various other drugs or substances
may cause your symptoms.
Always advise your doctor of any medications or treatments you are using,
including prescription, over-the-counter, supplements, herbal or alternative treatments.
Read more about medication causes of Rhabdomyolysis
When combined, certain drugs, medications, substances or toxins may react causing Rhabdomyolysis as a symptom.
The list below is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.
See full list of 341 drug interactions causing Rhabdomyolysis
The following medical news items are relevant to causes of Rhabdomyolysis:
As with all medical conditions, there may be many causal factors. Further relevant information on causes of Rhabdomyolysis may be found in:
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Rhabdomyolysis follows direct injury to the skeletal muscle fibers, specifically the sarcolemma, which then release myoglobin into the bloodstream. Myoglobin is an oxygen-binding protein pigment found in skeletal muscle. When this muscle is damaged, myoglobin is released into the bloodstream. It’s then filtered by the kidneys.
Myoglobin may occlude the structures of the kidney causing damage, such as acute tubular necrosis or kidney failure. Myoglobin can also cause kidney failure because it breaks down into potentially toxic compounds. Necrotic skeletal muscle may cause massive fluid shifts from the bloodstream into the muscle, reducing the relative fluid volume of the body and leading to shock and reduced blood flow to the kidneys.
The disorder may be caused by any condition that results in damage to skeletal muscle. Rhabdomyolysis may result from blunt trauma; extensive burn injury; viral, bacterial, or fungal infection (such as legionnaire’s disease or, especially, influenza type A or B); prolonged immobilization; near electrocution or near drowning; metabolic or genetic factors; drug therapy; or toxins. Heavy exercise in children may result in rhabdomyolysis. Other causes include shaken baby syndrome, exposure to extreme cold, heatstroke, and snakebite.
In the United States, rhabdomyolysis affects about 8% to 15% of people with acute renal failure and has a slightly higher incidence in men than in women. The overall mortality rate is 5%. It can occur in infants, toddlers, and adolescents who inherited enzyme deficiencies of carbohydrate and lipid metabolism or those with inherited myopathies, such as Duchenne’s muscular dystrophy, and malignant hyperthermia.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Rhabdomyolysis follows direct injury to the muscle fibers, specifically the sarcolemma, which then release myoglobin into the bloodstream. The myoglobin alters filtration in the kidneys, resulting in damage and failure.
Rhabdomyolysis may result from blunt trauma; extensive burn injury; viral, bacterial, or fungal infection (such as legionnaire’s disease or, especially, influenza type A or B); prolonged immobilization; near electrocution or near drowning; metabolic or genetic factors; drug therapy; or toxins. Heavy exercise in children may result in rhabdomyolysis. Other causes include shaken baby syndrome, exposure to extreme cold, heatstroke, and snakebite.
Risk factors include alcohol abuse, recent soft-tissue compression, and seizure activity.
Source: Handbook of Diseases, 2003
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