Causes of Rotavirus
Rotavirus Causes: Book Excerpts
Medical news summaries relating to Rotavirus:
The following medical news items are relevant to causes of Rotavirus:
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As with all medical conditions,
there may be many causal factors.
Further relevant information on causes of Rotavirus may be found in:
Causes of Rotavirus: Online Medical Books
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Rotavirus:
Rotavirus - pathophysiology
(The 5-Minute Pediatric Consult)
The cause of diarrhea is unknown but is believed to be a result of multiple disruptions in the normal mechanisms of water reabsorption in the gut:
- Peptides encoded in the viral genome disrupt the transport of glucose and salt, resulting in increased water within the gut.
- Decreased levels of intestinal disaccharidases, including lactase, result in malabsorption of sugars.
- Viral replication within enterocytes results in atrophy and ischemia of small intestinal villi.
- Infection with rotavirus results in activation of the enteric nervous system, resulting in abnormal stimulation of water secretion into the GI tract.
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Source: The 5-Minute Pediatric Consult, 2008
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