Clinical Trials for SCID

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for SCID is grouped into the following categories:-

• View by trial name
• View by drugs used in SCID clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for SCID:

• Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006) - anti-thymocyte globulin,busulfan,cyclophosphamide,cyclosporine,etoposide,methotrexate,methylprednisolone,prednisone
• Pilot Study of Allogeneic Bone Marrow Transplantation Plus Cyclosporine and Mycophenolate Mofetil to Induce Mixed Hematopoietic Chimerism in Patients With Primary T-Cell Immunodeficiency Disorders - This study is currently recruiting patients (Current: 23 Nov 2006) - cyclosporine,mycophenolate mofetil
• Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - Filgrastim,Alemtuzumab
• Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study - This study has been completed (Current: 23 Nov 2006) - ADA PBSC,ADA Umbilical Cord Blood Cells,Transduced Lymphocytes
• Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency - This study is currently recruiting patients (Current: 23 Nov 2006) - BB-IND 8556
• Cord Blood Stem Cell Transplantation Study (COBLT) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Use of G-CSF to Obtain Blood Cell Precursors - This study is currently recruiting patients (Current: 23 Nov 2006)
• Genetic Analysis of Immune Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
• Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCID - This study is currently recruiting patients (Current: 23 Nov 2006)
• Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID) - This study is currently recruiting patients (Current: 23 Nov 2006) - Gamma Chain Transduced CD34+ Cells
• Genetic Basis of Immunodeficiency - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients - This study has been completed (Current: 23 Nov 2006) - Immune Globulin Intravenous (Human) , 10%
• IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency - This study is currently recruiting patients (Current: 23 Nov 2006) - Busulfan, Fludarabine and ATG
• Developing Newborn Screening for Infants With Primary Immunodeficiency - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for SCID

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for SCID:

• ADA PBSC - Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study - This study has been completed (Current: 23 Nov 2006)
• ADA Umbilical Cord Blood Cells - Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study - This study has been completed (Current: 23 Nov 2006)
• Alemtuzumab - Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Anti-Thymocyte Globulin - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• BB-IND 8556 - Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfan, Fludarabine and ATG - IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfan - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Cyclosporine - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Cyclosporine - Pilot Study of Allogeneic Bone Marrow Transplantation Plus Cyclosporine and Mycophenolate Mofetil to Induce Mixed Hematopoietic Chimerism in Patients With Primary T-Cell Immunodeficiency Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
• Etoposide - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Filgrastim - Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Gamma Chain Transduced CD34+ Cells - Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Immune Globulin Intravenous (Human) , 10% - Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients - This study has been completed (Current: 23 Nov 2006)
• Methotrexate - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Methylprednisolone - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil - Pilot Study of Allogeneic Bone Marrow Transplantation Plus Cyclosporine and Mycophenolate Mofetil to Induce Mixed Hematopoietic Chimerism in Patients With Primary T-Cell Immunodeficiency Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prednisone - Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Transduced Lymphocytes - Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study - This study has been completed (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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