Clinical Trials for Sex chromosome conditions

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Sex chromosome conditions is grouped into the following categories:-

• View by trial name
• View by drugs used in Sex chromosome conditions clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Sex chromosome conditions:

• Clinical Study of Oral Endosseous Titanium Implants in Edentulous Subjects - This study has been completed (Current: 23 Nov 2006)
• Effect of Biosynthetic Growth Hormone and/or Ethinyl Estradiol on Adult Height in Patients With Turner Syndrome - This study has been completed (Current: 23 Nov 2006) - Growth Hormone (Humatrope)
• The Effects of Estrogen on Cognition in Girls With Turner Syndrome - This study has been completed (Current: 23 Nov 2006)
• The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - Humatrope,Oxandrolone
• Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome - This study has been completed (Current: 23 Nov 2006) - Estrogen
• Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - growth hormone,oxandrolone
• Turner Syndrome: Genotype and Phenotype - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hormone Replacement Therapy to Treat Turner Syndrome - This study has been completed (Current: 23 Nov 2006) - TMTDS
• The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - estrogen,androgen
• Effects of CX516 on Functioning in Fragile X Syndrome and Autism - This study has been completed (Current: 23 Nov 2006) - CX516 (Ampalex®)
• Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD) - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Study to Evaluate Subjects With Turner Syndrome Treated With Growth Hormone - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study to Identify Markers of Insulin Resistance During Growth Hormone Treatment for Short Stature - This study is currently recruiting patients (Current: 23 Nov 2006) - somatropin (rDNA)
• Defining the Optimal Hormonal Replacement Therapy in Turner Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - estradiol
• Estrogen Treatment (Oral Vs. Patches) in Turner Syndrome - This study has been completed (Current: 23 Nov 2006) - 17 beta estradiol
• Somatropin Treatment to Final Height in Turners - This study is no longer recruiting patients (Current: 23 Nov 2006) - Somatropin
• An Open-Label Trial of Donepezil in Fragile X Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - Donepezil
• Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq - This study is currently recruiting patients (Current: 23 Nov 2006) - Somatropin (rDNA origin)
• An Open-Label, Multi-Centre, Phase III Study of Local Tolerability of ZOMACTON 10MG - This study has been completed (Current: 23 Nov 2006) - ZOMACTON
• Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - Somatropin,No somatropin
• Luveris(Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (LH <1.2 IU/L) - This study is currently recruiting patients (Current: 23 Nov 2006) - Luveris®(lutrpoin alfa for injection)
• Androgen Effect on Klinefelter Syndrome Motor Outcome - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - androgen oxandrolone
• Letrozole Treatment in Normal and GnRH Deficient Women - This study is currently recruiting patients (Current: 23 Nov 2006) - Letrozole,NAL-GLU GnRH antagonist,GnRH
• Protein Synthesis in the Brain of Patients With Fragile X Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Pulsatile GnRH in Anovulatory Infertility - This study is currently recruiting patients (Current: 23 Nov 2006) - GnRH

Drugs used in Clinical Trials for Sex chromosome conditions

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Sex chromosome conditions:

• 17 beta estradiol - Estrogen Treatment (Oral Vs. Patches) in Turner Syndrome - This study has been completed (Current: 23 Nov 2006)
• Androgen Oxandrolone - Androgen Effect on Klinefelter Syndrome Motor Outcome - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Androgen - The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• CX516 (Ampalex®) - Effects of CX516 on Functioning in Fragile X Syndrome and Autism - This study has been completed (Current: 23 Nov 2006)
• Donepezil - An Open-Label Trial of Donepezil in Fragile X Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Estradiol - Defining the Optimal Hormonal Replacement Therapy in Turner Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Estrogen - Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome - This study has been completed (Current: 23 Nov 2006)
• Estrogen - The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• GnRH - Letrozole Treatment in Normal and GnRH Deficient Women - This study is currently recruiting patients (Current: 23 Nov 2006)
• GnRH - Pulsatile GnRH in Anovulatory Infertility - This study is currently recruiting patients (Current: 23 Nov 2006)
• Growth Hormone (Humatrope) - Effect of Biosynthetic Growth Hormone and/or Ethinyl Estradiol on Adult Height in Patients With Turner Syndrome - This study has been completed (Current: 23 Nov 2006)
• Growth Hormone - Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Humatrope - The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Letrozole - Letrozole Treatment in Normal and GnRH Deficient Women - This study is currently recruiting patients (Current: 23 Nov 2006)
• Luveris®(lutrpoin alfa for injection) - Luveris(Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (LH <1.2 IU/L) - This study is currently recruiting patients (Current: 23 Nov 2006)
• NAL-GLU GnRH antagonist - Letrozole Treatment in Normal and GnRH Deficient Women - This study is currently recruiting patients (Current: 23 Nov 2006)
• No somatropin - Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Oxandrolone - Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Oxandrolone - The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Somatropin (Rdna) - Study to Identify Markers of Insulin Resistance During Growth Hormone Treatment for Short Stature - This study is currently recruiting patients (Current: 23 Nov 2006)
• Somatropin (rDNA origin) - Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq - This study is currently recruiting patients (Current: 23 Nov 2006)
• Somatropin - Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Somatropin - Somatropin Treatment to Final Height in Turners - This study is no longer recruiting patients (Current: 23 Nov 2006)
• TMTDS - Hormone Replacement Therapy to Treat Turner Syndrome - This study has been completed (Current: 23 Nov 2006)
• ZOMACTON - An Open-Label, Multi-Centre, Phase III Study of Local Tolerability of ZOMACTON 10MG - This study has been completed (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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