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Diseases » Sickle Cell Anemia » Research
 

Cure Research for Sickle Cell Anemia

Cure Research list for Sickle Cell Anemia:

The list of research areas and treatments under analysis mentioned in various sources for Sickle Cell Anemia includes:

Curable Types of Sickle Cell Anemia

Possibly curable or rare types of Sickle Cell Anemia include:

  • Infectious crisis of sickle cell anemia
  • Vaso-occlusive crisis of sickle cell anemia
  • Septic arthritis due to sickle cell anemia
  • more curable types...»

Rare Types of Sickle Cell Anemia:

Some rare types of Sickle Cell Anemia include:

  • Bone marrow toxins( phenylbutazone) induced sickle cell anemia
  • Rib infarction induced by sickle cell anemia
  • Synovial thrombosis caused by sickle cell anemia
  • Pulmonary infarction caused by sickle cell anemia
  • more rare types...»

Treatments for Sickle Cell Anemia

Treatments to consider for Sickle Cell Anemia may include:

Medical Research Breakthroughs and Sickle Cell Anemia

Clumps of Red and White Blood Cells may contribute To Sickle Cell Disease: Patients with sickle cell disease are known to have malformed, "sickle-shaped" red blood cells -- which are normally disc-shaped -- that can cause sudden painful episodes when they block small blood vessels. The study done at Chapel Hill shows that blood from sickle cell patients also contains clumps, or aggregates, of red and white blood cells that may contribute to the blockages. The study marks the first time that aggregates made up of red blood cells and white blood cells have been found in whole blood from sickle cell patients. The study also shows how the red and white blood cells adhere to one another: the interaction is mediated by a particular protein, integrin alpha four beta one.Normal red blood cells don't interact with white blood cells. But tests with isolated cells that young red blood cells (reticulocytes) would interact with white blood cells and form aggregates with them. All the samples taken from patients with the sickle cell disease showed that they had clumps, though some had only a few, while others had thousands. The team didn't see clumps in samples from patients without sickle cell disease. The team saw the aggregates only when she used an anticoagulant that doesn't remove calcium. They also are trying to study more in Hydroxyurea which is commonly used to treat Sickle Cell disease.

Cure Research discussion for Sickle Cell Anemia:

Genes and Disease by the National Center for Biotechnology (Excerpt)

A mouse model of SCA has been developed and is being used to evaluate the effectiveness of potential new therapies for SCA. (Source: Genes and Disease by the National Center for Biotechnology)

Hydroxyurea in Pediatric Patients with Sickle Cell Disease: NHLBI (Excerpt)

A Phase I/II study ( PED-HUG) was supported by the NHLBI to determine the therapeutic dose of hydroxyurea in children with 3 or more painful episodes per year and to identify any short-term toxicities. (Source: excerpt from Hydroxyurea in Pediatric Patients with Sickle Cell Disease: NHLBI)

NHLBI, Fact Sheet Multicenter Study of Hydroxyurea for Sickle Cell Anemia: NHLBI (Excerpt)

Several other drugs under investigation (erythropoietin, butyrate and related compounds) may work together with hydroxyurea to make it more effective, but those studies are still in progress. Bone marrow transplantation can really cure the disease, but the risks are high, and only a small number of young patients are good candidates for that form of experimental therapy. Some day gene therapy may provide a safe and effective cure, and that will be some years in the future. (Source: excerpt from NHLBI, Fact Sheet Multicenter Study of Hydroxyurea for Sickle Cell Anemia: NHLBI)

Medical research for Sickle Cell Anemia: medical news summaries:

The following medical news items are relevant to medical research for Sickle Cell Anemia:

Sickle Cell Anemia Treatment: Book Excerpts

Clinical Trials for Sickle Cell Anemia

Some of the clinical trials for Sickle Cell Anemia include:

Evidence Based Medicine Research for Sickle Cell Anemia

Medical research papers related to Sickle Cell Anemia include:

Click here to find more evidence-based articles on the TRIP Database


 » Next page: Deaths from Sickle Cell Anemia

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