Clinical Trials for Sickle Cell Anemia

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Sickle Cell Anemia is grouped into the following categories:-

• View by trial name
• View by drugs used in Sickle Cell Anemia clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Sickle Cell Anemia:

• A Study of the Efficacy and Safety of ICA-17043 (With or Without Hydroxyurea) in Patients With Sickle Cell Anemia. - This study has been completed (Current: 23 Nov 2006) - ICA-17043
• A Study Evaluating the Long-Term Safety of ICA-17043 in Sickle Cell Disease Patients With or Without Hydroxyurea Therapy - This study is currently recruiting patients (Current: 23 Nov 2006) - ICA-17043
• Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide,INO Pulse/NO Delivery System
• Trial of Oral Glutamine in Patients With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Glutamine
• Use of Hydroxyurea and Magnesium Pidolate for Treatment of Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - Magnesium Pidolate, Hydroxyurea
• MAST Magnesium for Sickle Cell Acute Crisis in Children - This study is currently recruiting patients (Current: 23 Nov 2006) - Magnesium Sulfate
• A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling Disorders - This study has been completed (Current: 23 Nov 2006)
• L-Glutamine Therapy for Sickle Cell Anemia and Sickle 0 Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006) - L-glutamine
• Aspirin Prophylaxis in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - aspirin
• Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
• Safety of ICL670 Vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions - This study is no longer recruiting patients (Current: 23 Nov 2006) - ICL670,deferoxamine
• Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Intravenous Ketorolac,Ibuprofen
• Priapism in Men With Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Evaluation of Hydroxyurea Plus L-Arginine or Sildenafil to Treat Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Hydroxyurea,L-Arginine,Sildenafil
• Heart Disease in Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Erythropoietin and Hydroxyurea
• Bosentan to Treat Pulmonary Arterial Hypertension in Sickle Cell Disease (Asset 1 Study) - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
• Bosentan to Treat Pulmonary Hypertension in Sickle Cell Disease (Asset 2 Study) - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
• Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea for the Treatment of Patients With Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
• Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia - This study has been completed (Current: 23 Nov 2006)
• Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes - This study is currently recruiting patients (Current: 23 Nov 2006) - clotrimazole,hydroxyurea
• Phase III Randomized Study of Poloxamer 188 for Vaso-Occlusive Crisis of Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - poloxamer 188
• Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers - This study is currently recruiting patients (Current: 23 Nov 2006) - arginine butyrate
• Bone Marrow Transplantation in Treating Children With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - cyclosporine,fludarabine,mycophenolate mofetil
• Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - clotrimazole,hydroxyurea
• Pilot Study of Fructose for Sickle Cell Crisis - This study has been completed (Current: 23 Nov 2006) - fructose,placebo
• Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders - This study has been completed (Current: 23 Nov 2006) - anti-thymocyte globulin,busulfan,cyclophosphamide
• Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Anti-thymocyte globulin,busulfan,Cyclosporine,Fludarabine,mycophenolate mofetil
• Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nitric Oxide to Improve Blood Flow in Sickle Cell Disease - This study has been completed (Current: 23 Nov 2006) - L-NMMA,Acetylcholine
• Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide
• Home Based Massage and Relaxation for Sickle Cell Pain - This study is currently recruiting patients (Current: 23 Nov 2006)
• Silent Cerebral Infarct Multi-Center Clinical Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Oxypurinol,L-NMMA,Acetylcholine
• Natural History of Sickle Cell Disease and Other Hemolytic Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
• Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - L-NMMA,Sodium Nitrite
• A Stratified Sickle Event Randomized Trial (ASSERT) - This study is currently recruiting patients (Current: 23 Nov 2006) - ICA-17043
• Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Inhaled Nitric Oxide for Pediatric Painful Sickle Crisis - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide
• Haploidentical Stem Cell (HSC)Transplantation for Sickle Cell Disease Patients With a Stroke/Abnormal TCD - This study is currently recruiting patients (Current: 23 Nov 2006)
• Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies - This study is currently recruiting patients (Current: 23 Nov 2006) - Busulfex,Fludarabine,Alemtuzumab (CAMPATH)
• A 1-Year Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Effects on Liver Iron Concentration of Deferasirox and Deferoxamine in Children and Adults With Sickle Cell Disease and Transfusional Hemosiderosis - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload. - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Steroid Treatment for Sickle Cell Pain Crisis - This study is currently recruiting patients (Current: 23 Nov 2006) - Methylprednisolone plus prednisone taper
• Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
• PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - L-citrulline tablets, 1000 mg
• Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
• A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Study - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
• Hypnosis to Manage Pain and Symptoms in Patients With Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Presumptive treatment with sulfadoxine- pyrimethamine
• Pain Management Protocol for Pediatric Sickle Cell Disease - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Penicillin Prophylaxis in Sickle Cell Disease (PROPS) - This study has been completed (Current: 23 Nov 2006) - penicillin
• Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH) - This study is no longer recruiting patients (Current: 23 Nov 2006) - hydroxyurea
• Stroke Prevention in Sickle Cell Anemia (STOP 1) - This study has been completed (Current: 23 Nov 2006)
• Pediatric Hydroxyurea in Sickle Cell Anemia (PED HUG) - This study has been completed (Current: 23 Nov 2006) - hydroxyurea
• Cooperative Study of The Clinical Course of Sickle Cell Disease - This study has been completed (Current: 23 Nov 2006)
• Investigation of Selected Patient Groups From The Cooperative Study of Sickle Cell Disease - This study has been completed (Current: 23 Nov 2006)
• Cerebrovascular Involvement in Sickle Cell Disease - Comprehensive Sickle Cell Center - This study has been completed (Current: 23 Nov 2006)
• Prevention of Cerebral Infarction in Sickle Cell Anemia - Comprehensive Sickle Cell Center - This study has been completed (Current: 23 Nov 2006)
• Neuropsychological Studies of Children With Sickle Cell - This study has been completed (Current: 23 Nov 2006)
• Indices of Severity and Prognosis for Sickle Cell Disease - This study has been completed (Current: 23 Nov 2006)
• Hemostasis in Sickle Cell Disease--Infancy to Adulthood - This study has been completed (Current: 23 Nov 2006)
• Stroke Prevention in Sickle Cell Anemia (STOP 2) - This study has been completed (Current: 23 Nov 2006)
• Induction of Stable Chimerism for Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Immunosuppression
• Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Sangstat,Cyclophosphamide,Busulfan,Mycophenolate Mofetil,Cyclosporine
• Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Arginine hydrochloride
• L-Glutamine Therapy for Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006) - L-glutamine
• Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Busulfex,fludarabine
• Pain in Sickle Cell Epidemiologic Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pediatrics:Chlamydia, Sickle Cell Anemia and Stroke Risk - Ancillary to STOP II - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Transcranial Doppler (TCD) Ultrasound of Subjects Enrolled in BABY HUG - Ancillary to BABY HUG - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
• Quality of Life of Children With Sickle Cell Disease Who Are Getting Chronic Transfusions With a Lifeport - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dipyridamole/Magnesium To Improve Sickle Cell Hydration - This study is currently recruiting patients (Current: 23 Nov 2006) - oral dipyridamole, oral magnesium, or a combination of both
• Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006) - FLUDARABINE,CAMPATH-IH,FK506,G-SCF (Granulocyte-colony stimulating factor)
• Bone Marrow Transplant From Related Donor for Patients With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006) - Campath -1H,Dilantin,Busulfan,Cyclophosphamide
• Development of a Hospital-Based Home Program for the Use of Inhaled Nitric Oxide in the Chronic Management of Severe Cardiopulmonary Diseases - This study is currently recruiting patients (Current: 23 Nov 2006) - INOmax (nitric oxide for inhalation)
• Kid Cards: Teaching Kids About Medicines - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Codeine in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Codeine (30 mg)
• Stem Cell Transplant for Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Busulfan, Fludarabine and Anti-Thymocyte Globulin (ATG)
• Stem Cell Transplants With Identical Donors for Patients With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - Busulfan,Cyclophosphamide,Mesna,Anti-Thymocyte Globulin,Cyclosporine,Methotrexate
• Study of Blood Platelets in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Analysis of T-Cell Immune Reconstitution Following Allogeneic Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Disease (ImmuneReconstSCD) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain - This study is currently recruiting patients (Current: 23 Nov 2006) - ACTIQ (Oral Transmucosal Fentanyl Citrate [OTFC])
• Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Ketamine
• SALT: Alternative Donor Bone Marrow and Cord Blood Transplantation for High Risk Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH) - This study is currently recruiting patients (Current: 23 Nov 2006) - Bosentan
• Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH) - This study is currently recruiting patients (Current: 23 Nov 2006) - bosentan
• Mobilization and Handling of Stem Cells for Transplant From Healthy Volunteers With Sickle Cell Trait - This study has been completed (Current: 23 Nov 2006)
• The Effect of Oral Magnesium Pidolate on How Often Painful Crises Happens in Patients With Hemoglobin SC Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Mg Pidolate
• Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias - This study is currently recruiting patients (Current: 23 Nov 2006) - Alemtuzumab (Campath® (Registered Trademark)),Sirolimus (Rapamune® (Registered Trademark))
• Efficacy/Safety Study of ACTIQ for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP) - This study is currently recruiting patients (Current: 23 Nov 2006) - ACTIQ®
• Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006) - Nitric Oxide/INP Pulse Delivery,Nitric Oxide/INO Pulse Delivery

Drugs used in Clinical Trials for Sickle Cell Anemia

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Sickle Cell Anemia:

• ACTIQ (Oral Transmucosal Fentanyl Citrate [OTFC]) - Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain - This study is currently recruiting patients (Current: 23 Nov 2006)
• ACTIQ® - Efficacy/Safety Study of ACTIQ for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Acetylcholine - Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Acetylcholine - Nitric Oxide to Improve Blood Flow in Sickle Cell Disease - This study has been completed (Current: 23 Nov 2006)
• Alemtuzumab (CAMPATH) - Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies - This study is currently recruiting patients (Current: 23 Nov 2006)
• Alemtuzumab (Campath® (Registered Trademark)) - Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias - This study is currently recruiting patients (Current: 23 Nov 2006)
• Anti-Thymocyte Globulin - Stem Cell Transplants With Identical Donors for Patients With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Anti-Thymocyte Globulin - Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders - This study has been completed (Current: 23 Nov 2006)
• Anti-thymocyte globulin - Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Arginine Butyrate - Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Arginine hydrochloride - Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Aspirin - Aspirin Prophylaxis in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bosentan - A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bosentan - Bosentan to Treat Pulmonary Arterial Hypertension in Sickle Cell Disease (Asset 1 Study) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bosentan - Bosentan to Treat Pulmonary Hypertension in Sickle Cell Disease (Asset 2 Study) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bosentan - Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bosentan - Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfan, Fludarabine and Anti-Thymocyte Globulin (ATG). - Stem Cell Transplant for Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfan - Bone Marrow Transplant From Related Donor for Patients With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• Busulfan - Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfan - Stem Cell Transplants With Identical Donors for Patients With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Busulfan - Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders - This study has been completed (Current: 23 Nov 2006)
• Busulfan - Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfex - Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfex - Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• CAMPATH-IH - Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• Campath -1H - Bone Marrow Transplant From Related Donor for Patients With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• Clotrimazole - Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Clotrimazole - Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes - This study is currently recruiting patients (Current: 23 Nov 2006)
• Codeine (30 mg) - Codeine in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide - Bone Marrow Transplant From Related Donor for Patients With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• Cyclophosphamide - Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide - Stem Cell Transplants With Identical Donors for Patients With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide - Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders - This study has been completed (Current: 23 Nov 2006)
• Cyclosporine - Bone Marrow Transplantation in Treating Children With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Cyclosporine - Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclosporine - Stem Cell Transplants With Identical Donors for Patients With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Cyclosporine - Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - A 1-Year Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Effects on Liver Iron Concentration of Deferasirox and Deferoxamine in Children and Adults With Sickle Cell Disease and Transfusional Hemosiderosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferoxamine - Safety of ICL670 Vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Dilantin - Bone Marrow Transplant From Related Donor for Patients With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• Erythropoietin and Hydroxyurea - Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• FK506 - Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• FLUDARABINE - Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• Fludarabine - Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fludarabine - Bone Marrow Transplantation in Treating Children With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Fludarabine - Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Fludarabine - Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fructose - Pilot Study of Fructose for Sickle Cell Crisis - This study has been completed (Current: 23 Nov 2006)
• G-SCF (Granulocyte-colony stimulating factor) - Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk Hemoglobinopathies - This study has been terminated (Current: 23 Nov 2006)
• Glutamine - Trial of Oral Glutamine in Patients With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Evaluation of Hydroxyurea Plus L-Arginine or Sildenafil to Treat Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Hydroxyurea for the Treatment of Patients With Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Pediatric Hydroxyurea in Sickle Cell Anemia (PED HUG) - This study has been completed (Current: 23 Nov 2006)
• Hydroxyurea - Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes - This study is currently recruiting patients (Current: 23 Nov 2006)
• ICA-17043 - A Stratified Sickle Event Randomized Trial (ASSERT) - This study is currently recruiting patients (Current: 23 Nov 2006)
• ICA-17043 - A Study Evaluating the Long-Term Safety of ICA-17043 in Sickle Cell Disease Patients With or Without Hydroxyurea Therapy - This study is currently recruiting patients (Current: 23 Nov 2006)
• ICA-17043 - A Study of the Efficacy and Safety of ICA-17043 (With or Without Hydroxyurea) in Patients With Sickle Cell Anemia. - This study has been completed (Current: 23 Nov 2006)
• ICL670 - Safety of ICL670 Vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions - This study is no longer recruiting patients (Current: 23 Nov 2006)
• INO Pulse/NO Delivery System - Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises - This study is currently recruiting patients (Current: 23 Nov 2006)
• INOmax (nitric oxide for inhalation) - Development of a Hospital-Based Home Program for the Use of Inhaled Nitric Oxide in the Chronic Management of Severe Cardiopulmonary Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ibuprofen - Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Immunosuppression - Induction of Stable Chimerism for Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Intravenous Ketorolac - Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ketamine - Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• L-Arginine - Evaluation of Hydroxyurea Plus L-Arginine or Sildenafil to Treat Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• L-NMMA - Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• L-NMMA - Nitric Oxide to Improve Blood Flow in Sickle Cell Disease - This study has been completed (Current: 23 Nov 2006)
• L-NMMA - Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• L-citrulline tablets, 1000 mg - PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• L-glutamine - L-Glutamine Therapy for Sickle Cell Anemia and Sickle 0 Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• L-glutamine - L-Glutamine Therapy for Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Magnesium Pidolate, Hydroxyurea - Use of Hydroxyurea and Magnesium Pidolate for Treatment of Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Magnesium Sulfate - MAST Magnesium for Sickle Cell Acute Crisis in Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mesna - Stem Cell Transplants With Identical Donors for Patients With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Methotrexate - Stem Cell Transplants With Identical Donors for Patients With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Methylprednisolone plus prednisone taper - Steroid Treatment for Sickle Cell Pain Crisis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mg Pidolate - The Effect of Oral Magnesium Pidolate on How Often Painful Crises Happens in Patients With Hemoglobin SC Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil - Bone Marrow Transplantation in Treating Children With Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil - Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mycophenolate Mofetil - Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nitric Oxide/INO Pulse Delivery - Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nitric Oxide/INP Pulse Delivery - Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nitric Oxide - Inhaled Nitric Oxide for Pediatric Painful Sickle Crisis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nitric Oxide - Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nitric Oxide - Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Oral Dipyridamole, Oral Magnesium, Or A Combination Of Both - Dipyridamole/Magnesium To Improve Sickle Cell Hydration - This study is currently recruiting patients (Current: 23 Nov 2006)
• Oxypurinol - Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Penicillin - Penicillin Prophylaxis in Sickle Cell Disease (PROPS) - This study has been completed (Current: 23 Nov 2006)
• Placebo - Pilot Study of Fructose for Sickle Cell Crisis - This study has been completed (Current: 23 Nov 2006)
• Poloxamer 188 - Phase III Randomized Study of Poloxamer 188 for Vaso-Occlusive Crisis of Sickle Cell Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Presumptive treatment with sulfadoxine- pyrimethamine - Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sangstat - Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sildenafil - Evaluation of Hydroxyurea Plus L-Arginine or Sildenafil to Treat Sickle Cell Anemia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Sirolimus (Rapamune® (Registered Trademark)) - Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sodium Nitrite - Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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