Clinical Trials for Sinusitis

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Sinusitis is grouped into the following categories:-

• View by trial name
• View by drugs used in Sinusitis clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Sinusitis:

• A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
• Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Azithromycin,Telithromycin
• A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 Mg for 5 Days. - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
• Guidelines for Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Amoxicillin potassium clavulanate
• A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis (Sinus Infection) in Adults - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
• Preventing Frequent Sinus Infections in HIV-Infected Patients - This study has been terminated (Current: 23 Nov 2006) - Pseudoephedrine hydrochloride,Guaifenesin,Cefuroxime axetil,Beclomethasone dipropionate
• Acupuncture and Herbal Treatment of Chronic HIV Sinusitis - This study has been completed (Current: 23 Nov 2006) - Clavulanate potassium,Pseudoephedrine hydrochloride,Amoxicillin trihydrate
• Non-Rhinologic Etiologies of Headaches and Facial Pain in Tertiary Care Setting - This study is currently recruiting patients (Current: 23 Nov 2006)
• Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children - This study has been completed (Current: 23 Nov 2006)
• Xolair in Patients With Chronic Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Anti-IgE antibody omalizumab
• Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Treatment of Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Acetaminophen,Amoxicillin,Dextromethorphan hydrobromide,Mucinex OTC,Pseudoephedrine,Saline spray (0.65%)
• CHOOSE : Telithromycin, Acute Bacterial Sinusitis - This study is no longer recruiting patients (Current: 23 Nov 2006) - Telithromycin
• Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers - This study is currently recruiting patients (Current: 23 Nov 2006) - almotriptan or pseudoephedrine
• A Study To Measure The Level Of Drug In Nasal Tissue And Blood After Taking A Single 2g Dose Or 500mg Tablets For Up To - This study is currently recruiting patients (Current: 23 Nov 2006) - Zithromaxâ„¢ (azithromycin) 500mg tablets
• Hemostatic Matrix in Endoscopic Sinus Surgery - This study has been completed (Current: 23 Nov 2006)
• Outcomes of Patients Not Responding to Antibiotics in the Community - This study has been completed (Current: 23 Nov 2006) - all macrolide antibiotics,all beta-lactam antibiotics
• Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Zmax Compared to Augmentin in Sinusitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Azithromycin Extended Release,Amoxicillin/Clavulanate
• A Trial of Point of Care Information in Ambulatory Pediatrics - This study has been completed (Current: 23 Nov 2006)
• A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Azithromycin SR
• Pharmacokinetic Profiles Of Amoxicillin 2000 Mg And Clavulanate 125 Mg In Adolescent Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - amoxicillin/clavulanate potassium
• Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Patients With Acute Sinusitis and Assessment of Quality of Life - This study is currently recruiting patients (Current: 23 Nov 2006) - Amoxicillin/Clavulanate (drug), Cefdinir (drug)
• Cleaning of the Nose After Sinus Surgery: Necessary or Only Bothersome? - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Pulmozyme
• Blown Nasal Secretion Measurements in Rhinosinusitis: Repeatability and Validity Compared to Nasal Lavage - This study has been completed (Current: 23 Nov 2006)
• Study of Nasal Irrigation Versus Nasal Spray for Chronic Nasal and Sinus Symptoms - This study is currently recruiting patients (Current: 23 Nov 2006)
• Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - probiotic containing L.rhamnosus R0011 strain
• Steroids and Methotrexate to Treat Systemic Vasculitis - This study has been completed (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Sinusitis

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Sinusitis:

• Acetaminophen - Treatment of Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• All Beta-Lactam Antibiotics - Outcomes of Patients Not Responding to Antibiotics in the Community - This study has been completed (Current: 23 Nov 2006)
• All Macrolide Antibiotics - Outcomes of Patients Not Responding to Antibiotics in the Community - This study has been completed (Current: 23 Nov 2006)
• Almotriptan Or Pseudoephedrine - Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Amoxicillin potassium clavulanate - Guidelines for Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Amoxicillin trihydrate - Acupuncture and Herbal Treatment of Chronic HIV Sinusitis - This study has been completed (Current: 23 Nov 2006)
• Amoxicillin/Clavulanate (drug), Cefdinir (drug) - Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Patients With Acute Sinusitis and Assessment of Quality of Life - This study is currently recruiting patients (Current: 23 Nov 2006)
• Amoxicillin/Clavulanate Potassium - Pharmacokinetic Profiles Of Amoxicillin 2000 Mg And Clavulanate 125 Mg In Adolescent Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Amoxicillin/Clavulanate - Zmax Compared to Augmentin in Sinusitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Amoxicillin - Treatment of Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Anti-IgE antibody omalizumab - Xolair in Patients With Chronic Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Azithromycin Extended Release - Zmax Compared to Augmentin in Sinusitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Azithromycin SR - A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Azithromycin - Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Beclomethasone dipropionate - Preventing Frequent Sinus Infections in HIV-Infected Patients - This study has been terminated (Current: 23 Nov 2006)
• Cefuroxime axetil - Preventing Frequent Sinus Infections in HIV-Infected Patients - This study has been terminated (Current: 23 Nov 2006)
• Clavulanate potassium - Acupuncture and Herbal Treatment of Chronic HIV Sinusitis - This study has been completed (Current: 23 Nov 2006)
• Dextromethorphan hydrobromide - Treatment of Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Guaifenesin - Preventing Frequent Sinus Infections in HIV-Infected Patients - This study has been terminated (Current: 23 Nov 2006)
• Levofloxacin - A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis (Sinus Infection) in Adults - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Levofloxacin - A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 Mg for 5 Days. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Levofloxacin - A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mucinex OTC - Treatment of Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Probiotic Containing L.Rhamnosus R0011 Strain - Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Pseudoephedrine hydrochloride - Acupuncture and Herbal Treatment of Chronic HIV Sinusitis - This study has been completed (Current: 23 Nov 2006)
• Pseudoephedrine hydrochloride - Preventing Frequent Sinus Infections in HIV-Infected Patients - This study has been terminated (Current: 23 Nov 2006)
• Pseudoephedrine - Treatment of Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Pulmozyme - Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Saline spray (0.65%) - Treatment of Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Telithromycin - CHOOSE : Telithromycin, Acute Bacterial Sinusitis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Telithromycin - Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Zithromaxâ„¢ (azithromycin) 500mg tablets - A Study To Measure The Level Of Drug In Nasal Tissue And Blood After Taking A Single 2g Dose Or 500mg Tablets For Up To - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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