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Diseases » Smallpox » Clinical Trials

Clinical Trials for Smallpox

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Smallpox is grouped into the following categories:-

View by trial name

View by drugs used in Smallpox clinical trials

Clinical Trials by trial name

The format for each of the following is:

The name of the trial,
followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Smallpox:

Phase II Dose-Finding Study of Acambis MVA Smallpox Vaccine - This study is currently recruiting patients (Current: 23 Nov 2006)
ACAM 3000 MVA at Harvard Medical School - This study is currently recruiting patients (Current: 23 Nov 2006)
Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults - This study has been completed (Current: 23 Nov 2006)
Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax - This study is no longer recruiting patients (Current: 23 Nov 2006)
Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT - This study has been completed (Current: 23 Nov 2006)
Dryvax Seropositives #2 (Expanded Trial) - This study has been completed (Current: 23 Nov 2006)
APSV in Vaccinia Naive Adults - This study has been completed (Current: 23 Nov 2006)
Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination - This study is no longer recruiting patients (Current: 23 Nov 2006)
Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults - This study is currently recruiting patients (Current: 23 Nov 2006)
Safety Study of MVA Smallpox Vaccine in HIV-Positive Subjects Who Are Vaccinia Naive - This study is currently recruiting patients (Current: 23 Nov 2006)
A Randomized, Double-Blind, Placebo-Controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE) Smallpox Vaccine in Healthy Subjects - This study is currently recruiting patients (Current: 23 Nov 2006)
Dressing Preparations for Smallpox - This study has been completed (Current: 23 Nov 2006)
Safety and Immunogenicity of CJ-50300 - This study is currently recruiting patients (Current: 23 Nov 2006)
Combination Study With MVA BN and Dryvax - This study has been completed (Current: 23 Nov 2006)
Dose On Safety, Tolerability, and Immunogenicity of ACAM2000 Smallpox Vaccine in Adults With Previous Smallpox Vaccination - This study is no longer recruiting patients (Current: 23 Nov 2006)
A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults - This study has been completed (Current: 23 Nov 2006)
Dryvax Dilution-Prev Vacc Adults - This study has been completed (Current: 23 Nov 2006)
Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination - This study is no longer recruiting patients (Current: 23 Nov 2006)
Human Immune Responses Smallpox - This study has been completed (Current: 23 Nov 2006)
Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers - This study is no longer recruiting patients (Current: 23 Nov 2006)
VHA Clinicians and Bioterror Events: Interactive Web-Based Learning - This study is currently recruiting patients (Current: 23 Nov 2006)
Study on Safety, Tolerability and Immunogenicity of an MVA Vaccine Administered to Healthy Subjects - This study has been completed (Current: 23 Nov 2006)
Dose-Finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. - This study has been completed (Current: 23 Nov 2006)
Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects - This study has been completed (Current: 23 Nov 2006)
Safety Study of MVA Smallpox Vaccine in Subjects With a History of Atopic Dermatitis (AD) - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
Immune Responses to Smallpox Vaccination - This study is currently recruiting patients (Current: 23 Nov 2006)
Phase I Trial of Smallpox Vaccine - This study has been completed (Current: 23 Nov 2006) - Modified Vaccinia Virus Ankara TBC-M
Phase I/II Trial of Modified Vaccinia Virus Ankara (MVA) Vaccine Against Smallpox - This study has been completed (Current: 23 Nov 2006) - Modified Vaccinia Virus Ankara TBC-MVA
SIGA-246 to Treat Smallpox - This study is currently recruiting patients (Current: 23 Nov 2006) - SIGA-246
Evaluation and Treatment of Eye Complications of Vaccinia Vaccination - This study is currently recruiting patients (Current: 23 Nov 2006) - NP-016 Vaccine Immune Globulin (IV-VIG)
A Phase II Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE) Smallpox Vaccine in Subjects With Atopic Dermatitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of a Recombinant Vaccinia-HIV-1 IIIB Env/Gag/Pol Vaccine (TBC-3B) - This study has been completed (Current: 23 Nov 2006)
A Phase I, Multicenter, Randomized Trial to Evaluate the Safety and Immunogenicity of Vaccinia-Derived MN HIV-1 Recombinant Envelope Glycoprotein (rgp160) of Human Immunodeficiency Virus at Two Different Vaccination Schedules - This study has been completed (Current: 23 Nov 2006)
A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers - This study has been completed (Current: 23 Nov 2006)
Vaccinia Immune Globulin in Treating or Preventing Vaccinal Infection - This study has been terminated (Current: 23 Nov 2006) - Vaccinia Immune Globulin (Human)

Drugs used in Clinical Trials for Smallpox

The format for each of the following is:

The drug,
followed by the name of the trial,
followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Smallpox:

Modified Vaccinia Virus Ankara TBC-M - Phase I Trial of Smallpox Vaccine - This study has been completed (Current: 23 Nov 2006)
Modified Vaccinia Virus Ankara TBC-MVA - Phase I/II Trial of Modified Vaccinia Virus Ankara (MVA) Vaccine Against Smallpox - This study has been completed (Current: 23 Nov 2006)
NP-016 Vaccine Immune Globulin (IV-VIG) - Evaluation and Treatment of Eye Complications of Vaccinia Vaccination - This study is currently recruiting patients (Current: 23 Nov 2006)
SIGA-246 - SIGA-246 to Treat Smallpox - This study is currently recruiting patients (Current: 23 Nov 2006)
Vaccinia Immune Globulin (Human) - Vaccinia Immune Globulin in Treating or Preventing Vaccinal Infection - This study has been terminated (Current: 23 Nov 2006)

The trial data on this page has been sourced from