GIGANTISM
GIGANTISM: Excerpt from Algorithmic Diagnosis of Symptoms and Signs
Ask the Following Questions:
- Are there abnormal secondary sex characteristics? Patients with Klinefelter's syndrome, supermale, superfemale, sexual precocity, and virilism have abnormal secondary sex characteristics and a tall stature.
- Is there arachnodactyly? Arachnodactyly is associated with Marfan's syndrome and homocystinuria.
- Is there a family history? Patients with a family history of tall stature often have constitutional tall stature and not pituitary gigantism.
DIAGNOSTIC WORKUP
X-rays of the skull and a CT scan will help identify a pituitary eosinophilic adenoma, but serum growth hormone will also be elevated early, and FSH and LH may be depressed later. An MRI will be necessary to pick up microadenomas. Serum FSH and LH will be elevated in Klinefelter's syndrome. A chromosome study should be done to identify Klinefelter's syndrome, supermale, and superfemale. A serum testosterone, dihydrotestosterone, and dehydroepiandrosterone sulfate will be helpful in diagnosing sexual precocity and virilism caused by tumors and hyperplasia of the adrenal gland. Echocardiography and urinary hydroxyproline will help identify Marfan's syndrome, whereas a urine for homocystine will help diagnose homocystinuria. A thyroid profile should be done to rule out thyrotoxicosis.
Book Source Details
- Book Title: Algorithmic Diagnosis of Symptoms and Signs
- Author(s): R. Douglas Collins
- Year of Publication: 2003
- Copyright Details: Algorithmic Diagnosis of Symptoms and Signs, Copyright © 2003 Lippincott Williams & Wilkins.
More About Soto's Syndrome
More Medical Textbooks Online about Soto's Syndrome
Review other book chapters online related to Soto's Syndrome:
Medical Books Excerpts
- GIGANTISM
- "Algorithmic Diagnosis of Symptoms and Signs" (2003)
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- GIGANTISM
- "Differential Diagnosis in Primary Care" (2007)
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- GIGANTISM
- "Differential Diagnosis in Primary Care" (2007)
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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.
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