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Hematologic Complications of HIV

Hematologic Complications of HIV: Excerpt from A Pocket Manual of Differential Diagnosis

Red Blood Cell Disorders

Etiologies of anemia
   HIV infection
M. avium   complex infection
   Parvovirus B19 infection
   Drugs, especially
       TMP/SMX
       Sulfonamides
       Interferon or ribavirin
       Azidothymidine (AZT)
       Ganciclovir
       Pentamidine
       Dideoxycytidine (DDC) Zalcitabine
       Lamivudine (3TC) (Epivir)
   Iron-deficiency anemia
   Autoimmune hemolytic anemia (AIHA)
Vitamin B₁₂   deficiency
   Blood loss
Bone marrow infiltration with infection (especially CMV, M. avium   complex)
   Bone marrow infiltration with malignancy (especially lymphoma)
   Hypersplenism
   Thrombotic thrombocytopenic purpura (TTP)

White Blood Cell Disorders

Etiologies of neutropenia or leukopenia
   HIV infection
   Drugs, especially
       DDC (Zalcitabine)
       3TC (Epivir)
       TMP/SMX
       Ganciclovir
       AZT (Retrovin)
Bone marrow infiltration with infection (especially CMV, M. avium   complex)
   Bone marrow infiltration with malignancy (especially lymphoma)
   Hypersplenism

Platelet Disorders

Etiologies of thrombocytopenia
   HIV infection
   CMV
   Parvovirus B19
   Fungal infections (especially Cryptococcus and Histoplasma)
   M. tuberculosis and M. avium   complex disseminated infections
   Hepatitis B and C
   HHV-6
   Thrombotic thrombocytopenic purpura (TTP)

Drugs Causing Multiple Hematologic Abnormalities
in Human Immunodeficiency Virus Infection

   Zidovudine (Retrovir or AZT)
   Ganciclovir
   TMP/SMX
   Sulfonamides
Interferon-α   or ribavirin, or both
   Pyrimethamine
   3TC (Epivir)
   Antineoplastic chemotherapy
   Dapsone
   Didanosine (DDI)
   DDC (Zalcitabine)
   Amphotericin B
   Pentamidine
   Fluconazole
   Rifabutin
   Clarithromycin

References

1. Hoeprich, pp. 635–636. See Bibliography, 1.
2. Kelley, p. 1874. See Bibliography, 2.
3. Blinder MA: Hematologic Problems, pp. 158–164. See Bibliography, 5.
4. Mandell, pp. 1225–1226. See Bibliography, 8.
5. Devita, pp. 429–433. See Bibliography, 9.
6. Wormser, pp. 542–546. See Bibliography, 10.
7. Mitsuyasu RM: Hematologic Disease, pp. 666–679. See Bibliography, 15.

Book Source Details

• Book Title: A Pocket Manual of Differential Diagnosis
• Author(s): Stephen N. Adler, Dianne B. Gasbarra
• Year of Publication: 1999
• Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.

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More About This Book: Title: A Pocket Manual of Differential Diagnosis Authors: Stephen N. Adler, Dianne B. Gasbarra Publisher: Lippincott Williams & Wilkins Copyright: 1999 ISBN: 0-78171-943-7

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