Commonly provoking scratching to gain relief, this unpleasant itching sensation affects the skin, certain mucous membranes, and the eyes. Most severe at night, pruritus may be exacerbated by increased skin temperature, poor skin turgor, local vasodilation, dermatoses, and stress.
The most common symptom of dermatologic disorders, pruritus may also result from a local or systemic disorder or from drug use. Physiologic pruritus, such as pruritic urticarial papules and plaques of pregnancy, may occur in primigravidas late in the third trimester. Pruritus can also stem from emotional upset or contact with skin irritants.
If the patient reports pruritus, have him describe its onset, frequency, and intensity. If pruritus occurs at night, ask whether it prevents him from falling asleep or awakens him after hefalls asleep. (Generally, pruritus related to dermatoses prevents—but doesn’t disturb—sleep.) Is the itching localized or generalized? When is it most severe? How long does it last? Is there a relationship to activities (physical exertion, bathing, applying makeup, or use of perfumes)?
Ask the patient how he cleans his skin. In particular, look for excessive bathing, harsh soaps, contact allergy, and excessively hot water. Does he have occupational exposure to known skin irritants such as glass fiber insulation or chemicals? Ask about the patient’s general health and the medications he takes (new medications are suspect). Has he recently traveled abroad? Does he have any pets? Does anyone else in the house report itching? Does exercise, stress, fear, depression, or illness seem to aggravate the itching? Ask about contact with skin irritants, previous skin disorders, and related symptoms. Obtain a complete drug history.
Examine the patient for signs of scratching, such as excoriation, purpura, scabs, scars, or lichenification. Look for primary lesions to help confirm dermatoses.
This disorder occasionally produces pruritus. Initially asymptomatic, anemia can later cause exertional dyspnea, fatigue, listlessness, pallor, irritability, headache, tachycardia, poor muscle tone and, possibly, murmurs. Chronic anemia causes spoon-shaped (koilonychia) and brittle nails (cheilosis), cracked mouth corners, a smooth tongue (glossitis), and dysphagia.
Anthrax is an acute infectious disease caused by the gram-positive, spore-forming bacterium Bacillus anthracis. It can occur in humans who are exposed to infected animals, tissue from infected animals, or biological warfare. Cutaneous anthrax occurs when the bacterium enters a cut or abrasion on the skin. The infection begins as a small, painless or pruritic macular or papular lesion resembling an insect bite. Within 1 to 2 days it develops into a vesicle and then a painless ulcer with a characteristic black, necrotic center. Lymphadenopathy, malaise, headache, or fever may develop.
All forms of conjunctivitis cause eye itching, burning, and pain along with photophobia, conjunctival injection, a foreign-body sensation, excessive tearing, and a feeling of fullness around the eye. Allergic conjunctivitis may also cause milky redness and a stringy eye discharge. Bacterial conjunctivitis typically causes brilliant redness and a mucopurulent, discharge that may make the eyelids stick together. Fungal conjunctivitis produces a thick, purulent discharge and crusting and sticking of the eyelid. Viral conjunctivitis may cause copious tearing—but little discharge—and preauricular lymph node enlargement.
Several types of dermatitis can cause pruritus accompanied by a skin lesion. Atopic dermatitis begins with intense, severe pruritus and an erythematous rash on dry skin at flexion points (antecubital fossa, popliteal area, and neck). During a flare-up, scratching may produce edema, scaling, and pustules. With chronic atopic dermatitis, lesions may progress to dry, scaly skin with white dermatographia, blanching, and lichenification.
Mild irritants and allergies can cause contact dermatitis, with itchy small vesicles that may ooze and scale and are surrounded by redness. A severe reaction can produce marked localized edema.
Dermatitis herpetiformis, most common in men between ages 20 and 50, initially causes intense pruritus and stinging. Between 8 and 12 hours later, symmetrically distributed lesions form on the buttocks, shoulders, elbows, and knees. Sometimes, they also form on the neck, face, and scalp. These lesions are erythematous and papular, bullous, or pustular.
Also known as pinworm or seatworm, this benign intestinal disease results from infection by Enterobius vermicularis. Adult worms live in the intestine; females migrate to the perianal region to deposit their eggs, causing intense perianal pruritus.
Anal pruritus may occur in patients with hemorrhoids along with rectal pain and constipation. External hemorrhoids may be seen outside the external anal sphincter; internal hemorrhoids are less obvious and less painful but more likely to cause rectal bleeding.
An important diagnostic clue to liver and gallbladder disease, pruritus is commonly accompanied by jaundice and may be generalized or localized to the palms and soles. Other characteristics include right-upper-quadrant pain, clay-colored stools, chills and fever, flatus, belching and a bloated feeling, epigastric burning, and bitter fluid regurgitation. Later, liver disease may produce mental changes, ascites, bleeding tendencies, spider angiomas, palmar erythema, dry skin, fetor hepaticus, enlarged superficial abdominal veins, bilateral gynecomastia, testicular atrophy or menstrual irregularities, and hepatomegaly.
Within 2 to 4 days of fever and malaise, pruritus, paresthesia or hyperesthesia, and severe, deep pain from cutaneous nerve involvement develop on the trunk or the arms and legs in a dermatome distribution. Up to 2 weeks after initial symptoms, red, nodular skin eruptions appear on the painful areas and become vesicular. About 10 days later, the vesicles rupture and form scabs.
This disease, which is most common in young adults, occasionally causes severe and unexplained itching. As the disease progresses, pruritus may become severe and unresponsive to treatment. Early nonspecific findings include persistent fever (occasionally, cyclic fever and chills), night sweats, fatigue, weight loss, malaise, and painless swelling of a cervical lymph node. Other lymph nodes may enlarge rapidly and cause pain, or they may enlarge slowly and be painless. Later findings include retroperitoneal node enlargement, hepatomegaly, splenomegaly, dyspnea, dysphagia, dry cough, hyperpigmentation, jaundice, and pallor.
Pruritus is an uncommon finding in this disorder. More characteristic signs and symptoms include fatigue, malaise, generalized lymphadenopathy, fever, hepatomegaly, splenomegaly, weight loss, pallor, bleeding, and palpitations.
This uncommon skin disease can cause moderate to severe pruritus that’s aggravated by stress. Characteristic oral lesions (white or gray, velvety, lacy, threadlike papules) develop on the buccal mucosa and may cause pain. Violet papules with white lines or spots develop later, usually on the genitalia, lower back, ankles, and shins. Nail distortion and atrophic alopecia may also occur.
Persistent rubbing and scratching cause localized pruritus and a circumscribed scaling patch with sharp margins. Later, the skin thickens and papules form.
With this disorder, reddish brown macules or papules (urticaria pigmentosa), along with patchy erythema and telangiectasia occur. Other signs and symptoms include pruritus, flushing, tachycardia, hypotension, and nausea.
Infrequently, this disorder produces pruritus. Other findings include severe, constant back pain that increases with exercise; achiness; joint swelling and tenderness; fever; malaise; slight peripheral neuropathy; and purpura.
Pruritus may precede other symptoms of this neoplastic disease by 10 years. It may persist into the first, or premycotic, stage, accompanied by erythematous lesions.
This disorder produces pruritus in the affected ear, along with a purulent discharge and gradual hearing loss.
A prominent symptom, pruritus occurs in the area of infestation. Pediculosis capitis (head lice) may also cause scalp excoriation from scratching, along with matted, foul-smelling, lusterless hair; occipital and cervical lymphadenopathy; and oval, gray-white nits on hair shafts.
Pediculosis corporis (body lice) initially causes small red papules (usually on the shoulders, trunk, or buttocks), which become urticarial from scratching. Later, rashes or wheals may develop. Untreated, pediculosis corporis produces dry, discolored, thickly encrusted, scaly skin with bacterial infection and scarring. In severe cases, it produces headache, fever, and malaise.
With pediculosis pubis (pubic lice), scratching commonly produces skin irritation. Nits or adult lice and erythematous, itching papules may appear in pubic hair or hair around the anus, abdomen, or thighs.
This disorder occasionally produces mild pruritus that’s aggravated by a hot bath or shower. It usually begins with an erythematous herald patch—a slightly raised, oval lesion about 2 to 6 cm in diameter. After a few days or weeks, scaly yellow-tan or erythematous patches erupt on the trunk and extremities and persist for 2 to 6 weeks. Occasionally, these patches are macular, vesicular, or urticarial.
This hematologic disorder can produce pruritus that’s generalized or localized to the head, neck, face, and extremities. The itching is typically aggravated by a hot bath or shower and can last from a few minutes to an hour. The patient’s oral mucosa may be deep purplish red, especially on the gingivae and tongue. His engorged gingivae ooze blood with even slight trauma.
Related findings include headache, dizziness, fatigue, dyspnea, paresthesia, impaired mentation, tinnitus, double or blurred vision, scotoma, hypotension, intermittent claudication, urticaria, ruddy cyanosis, and ecchymosis. GI effects include gastric distress, weight loss, and hepatosplenomegaly.
Pruritus and pain are common in psoriasis. This skin disorder typically begins with small erythematous papules that enlarge or coalesce to form red elevated plaques with silver scales on the scalp, chest, elbows, knees, back, buttocks, and genitals. Nail pitting may occur.
Localized or generalized pruritus occurs without symptoms of dermatologic or systemic disease. Anxiety or emotional lability may be evident.
Pruritus may develop gradually or suddenly with this disorder. It may be accompanied by ammonia breath odor, oliguria or anuria, lassitude, fatigue, irritability, decreased mental acuity, convulsions, coarse muscular twitching, muscle cramps, peripheral neuropathies, and coma. Renal failure also causes diverse GI signs and symptoms, such as anorexia, constipation or diarrhea, nausea, and vomiting.
Typically, scabies causes localized pruritus that awakens the patient. It may become generalized and persist up to 2 weeks after treatment. Threadlike lesions several millimeters long appear with a swollen nodule or red papule.
Gender Cue: In males, crusty lesions may form on the glans penis, penile shaft, and scrotum. In females, lesions may also be found on or around nipples. In both sexes the lesions have a predilection for skin folds. Crusty excoriated lesions form on the wrists, elbows, axillae, waistline, behind the knees and ankles. Excoriation from scratching is common.
Generalized pruritus may precede or accompany the characteristic signs and symptoms of this disorder: tachycardia, palpitations, weight loss despite increased appetite, diarrhea, tremors, an enlarged thyroid, dyspnea, nervousness, diaphoresis, heat intolerance and, possibly, exophthalmos.
This fungal infection causes severe foot pruritus, pain with walking, scales and blisters between the toes, and a dry, scaly squamous inflammation on the entire sole.
Extreme pruritus and stinging occur as transient erythematous or whitish wheals form on the skin or mucous membranes. Prickly sensations typically precede the wheals, which may affect any part of the body and may range from pinpoint to palm-sized or larger.
This disorder commonly causes localized pruritus and foul-smelling vaginal discharge that may be purulent, white or gray, and curdlike. Perineal pain and urinary dysfunction may also occur.
Typically, bedbug bites produce itching and burning over the ankles and lower legs, along with clusters of purpuric spots.
When mild and localized, an allergic reaction to such drugs as penicillin and sulfonamides can cause pruritus, erythema, an urticarial rash, and edema. However, with a severe drug reaction, anaphylaxis may occur.
Herb alert Ingestion of fruit pulp from the ginkgo tree can cause rapid formation of vesicles, resulting in severe itching.
Administer a topical or oral corticosteroid, an antihistamine, or a tranquilizer, as ordered. If the patient doesn’t have a localized infection or skin lesions, suspect a systemic disease and prepare him for a complete blood count and differential, erythrocyte sedimentation rate, protein electrophoresis, and radiologic studies.
Many adult disorders also cause pruritus in children, but they may affect different parts of the body. For instance, scabies may affect the head in infants, but not in adults. Pityriasis rosea may affect the face, hands, and feet of adolescents.
Some childhood diseases, such as measles and chickenpox, can cause pruritus.
Suggest ways to control pruritus. (See Controlling itching.)
Read excerpts from these other book chapters related to Aquagenic pruritus:
Copyright Details: Professional Guide to Signs & Symptoms (Fifth Edition), Copyright © 2008 Williams & Wilkins.
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More About This Book:
Title: Professional Guide to Signs & Symptoms (Fifth Edition) Authors: Springhouse Publisher: Lippincott Williams & Wilkins Copyright: 2006 ISBN: 1-58255-510-9 
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