Asterixis [Liver flap, flapping tremor]
A bilateral, coarse movement, asterixis is characterized by sudden relaxation of muscle groups holding a sustained posture. This elicited sign is most commonly observed in the wrists and fingers but may also appear during any sustained voluntary action. Typically, it signals hepatic, renal, or pulmonary disease.
To elicit asterixis, have the patient extend his arms, dorsiflex his wrists, and spread his fingers (or do this for him, if necessary). Briefly observe him for asterixis. Alternatively, if the patient has a decreased level of consciousness (LOC) but can follow verbal commands, ask him to squeeze two of your fingers. Consider rapid clutching and unclutching indications of asterixis. Or, elevate the patient’s leg off the bed and dorsiflex the foot. Briefly check for asterixis in the ankle. If the patient can tightly close his eyes and mouth, watch for irregular tremulous movements of the eyelids and corners of the mouth. If he can stick out his tongue, observe it for continuous quivering. (See Recognizing asterixis.)
Emergency interventions
Because asterixis may signal serious metabolic deterioration, quickly evaluate the patient’s neurologic status and vital signs. Compare these data with his baseline, and watch carefully for acute changes. Continue to closely monitor neurologic status, vital signs, and urine output.
Watch for signs of respiratory insufficiency, and be prepared to provide endotracheal intubation and ventilatory support. Also, be alert for complications of end-stage hepatic, renal, or pulmonary disease.
If the patient has hepatic disease, assess him for early indications of hemorrhage, including restlessness, tachypnea, and cool, moist, pale skin. (If the patient is jaundiced, check for pallor in the conjunctivae and mucous membranes of the mouth.) Be aware that hypotension, oliguria, hematemesis, and melena are late signs of hemorrhage. Prepare to insert a large-bore I.V. line for fluid and blood replacement. Position the patient flat in bed with his legs elevated 20 degrees. Begin or continue to administer oxygen.
If the patient has renal disease, briefly review the therapy he has received. If he’s on dialysis, ask about the frequency of treatments to help gauge the disease’s severity. Question a family member if the patient’s LOC is significantly decreased.
Then assess the patient for hyperkalemia and metabolic acidosis. Look for tachycardia, nausea, diarrhea, abdominal cramps, muscle weakness, hyperreflexia, and Kussmaul’s respirations. Prepare to administer sodium bicarbonate, calcium gluconate, dextrose, insulin, or sodium polystyrene sulfonate (Kayexalate).
If the patient has pulmonary disease, check for labored respirations, tachypnea, accessory muscle use, and cyanosis, which are critical signs. Prepare to provide ventilatory support by nasal cannula, mask, or intubation and mechanical ventilation.
Medical causes
Hepatic encephalopathy
A life-threatening disorder, hepatic encephalopathy initially causes mild personality changes and a slight tremor. The tremor progresses to asterixis—a hallmark of hepatic encephalopathy—and is accompanied by lethargy, aberrant behavior, and apraxia. Eventually, the patient becomes stuporous and displays hyperventilation. After slipping into a coma, the patient exhibits characteristic hyperactive reflexes, positive Babinski’s reflex, and fetor hepaticus. He also may experience bradycardia, decreased respirations, and seizures.
Respiratory insufficiency, severe
Characterized by life-threatening respiratory acidosis, severe respiratory insufficiency initially produces headache, restlessness, confusion, apprehension, and decreased reflexes. Eventually, the patient becomes somnolent and may demonstrate asterixis before slipping into a coma. Associated signs and symptoms of respiratory insufficiency include difficulty breathing and rapid, shallow respirations. The patient may be hypertensive in early disease but hypotensive later.
Uremic syndrome
Uremic syndrome is a life-threatening disorder that initially causes lethargy, somnolence, confusion, disorientation, behavior changes, and irritability. Eventually, signs and symptoms appear in diverse body systems. Asterixis is accompanied by stupor, paresthesia, muscle twitching, fasciculations, and footdrop. Other signs and symptoms include polyuria and nocturia followed by oliguria and then anuria, elevated blood pressure, signs of heart failure and pericarditis, Kussmaul’s respirations, anorexia, nausea, vomiting diarrhea, GI bleeding, weight loss, ammonia breath odor, and metallic taste (dysgeusia).
Other causes
Drugs
Certain drugs, such as the anticonvulsant phenytoin, may cause asterixis.
Special considerations
Provide simple comfort measures, such as allowing frequent rest periods to minimize fatigue and elevating the head of the bed to relieve dyspnea and orthopnea. Administer oil baths and avoid soap to relieve itching caused by jaundice and uremia. Provide emotional support to the patient and his family.
If the patient is intubated or has a decreased LOC, provide enteral or parenteral nutrition. Closely monitor serum and urine glucose levels to evaluate hyperalimentation. Because the patient will probably be on bed rest, reposition him at least once every 2 hours to prevent skin breakdown. Also observe strict hand-washing and aseptic techniques when changing dressings and caring for invasive lines because the patient’s debilitated state makes him prone to infection.
Pediatric pointers
End-stage hepatic, renal, and pulmonary disease may also cause asterixis in children.
Pictures
![Asterixis [Liver flap, flapping tremor] - 2489.png](/bookimages/8/2489.png)
Book Source Details
- Book Title: Professional Guide to Signs & Symptoms (Fifth Edition)
- Author(s): Springhouse
- Year of Publication: 2006
- Copyright Details: Professional Guide to Signs & Symptoms (Fifth Edition), Copyright © 2006 Lippincott Williams & Wilkins.
Other Book Chapters Related to Liver symptoms
Read excerpts from these other book chapters related to Liver symptoms:
Medical Books Excerpts
- JAUNDICE
- "Algorithmic Diagnosis of Symptoms and Signs" (2003)
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- JAUNDICE
- "Differential Diagnosis in Primary Care" (2007)
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- Jaundice
- "Handbook of Signs & Symptoms (Third Edition)" (2006)
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- Jaundice
- "A Pocket Manual of Differential Diagnosis" (1999)
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- Fatty liver
- "Professional Guide to Diseases (Eighth Edition)" (2005)
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- Hepatomegaly
- "Professional Guide to Signs & Symptoms (Fifth Edition)" (2006)
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- Hepatomegaly
- "The 10-Minute Diagnosis Manual: Symptoms and Signs in the Time-Limited Encounter" (2000)
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- Jaundice
- "The 10-Minute Diagnosis Manual: Symptoms and Signs in the Time-Limited Encounter" (2000)
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- Jaundice
- "Signs & Symptoms: A 2-in-1 Reference for Nurses" (2007)
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- Hepatomegaly
- "The Diagnostic Approach to Symptoms and Signs in Pediatrics" (2006)
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- Jaundice
- "The Diagnostic Approach to Symptoms and Signs in Pediatrics" (2006)
- [ read ]
- JAUNDICE
- "Differential Diagnosis in Primary Care" (2007)
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Copyright Details: Professional Guide to Signs & Symptoms (Fifth Edition), Copyright © 2008 Williams & Wilkins.
More About Causes of Liver symptoms
» Next page: Jaundice [Icterus] (Professional Guide to Signs & Symptoms (Fifth Edition))
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