- Enormous appetite?
Why: must consider the possibility of an insulinoma or Frohlich's syndrome (also have poorly developed genitals).
- Mental retardation?
Why: the presence of mental retardation with obesity should suggest Laurence-Moon-Bardet-Biedl syndrome or Prader-Willi syndrome.
- Headaches and visual disturbance?
Why: may suggest a variety of tumors including craniopharyngioma, optic glioma and pituitary tumors that may cause injury to the hypothalamus and result in excessive appetite and obesity.
- Chest pain?
Why: may suggest angina which may be a consequence of obesity.
- Low back pain, aggravation of knee and ankle pain?
Why: Obesity may cause a variety of bone and joint disturbances, including low back pain and aggravation of osteoarthritis, particularly of the knees and ankles.
- Symptoms of Diabetes mellitus?
Why: e.g. frequency of urination, excessive thirst, tiredness, fatigue, increased infections especially of the skin and genitals, blurry vision. Obesity is a major risk factor for diabetes mellitus type 2.
- Symptoms of complications of Diabetes mellitus?
Why: e.g. staphylococcal skin infections, tingling or numbness of the feet, impotence, heart attack, intermittent claudication due to peripheral vascular disease - these complications may be the presenting features of diabetes.
- Symptoms of Cushing's syndrome?
Why: e.g. unexplained weight gain especially central abdominal, change of appearance, moon-like face, thin skin, easy bruising, excessive facial hair growth, acne, muscle weakness, lack of or rare menstrual periods, poor libido, depression, psychosis, insomnia, frequent urination, excessive thirst, growth arrest in children.
- Symptoms of hypothyroidism?
Why: e.g. lethargy, unexplained weight gain, constipation, puffiness of face and eyes, hair loss, dry skin. Hypothyroidism is not usually associated with marked obesity.
- Symptoms of Acromegaly?
Why: e.g. excessive growth of hands, feet, nose, lips, face, jaw and tongue; weakness, sweating, headaches, loss of menstrual periods in females, reduced libido in males.
- Symptoms of insulinoma (insulin secreting tumor of the pancreas)?
Why: e.g. symptoms occur with fasting and are relieved by ingestion of carbohydrates and may include headache, confusion, visual disturbances, muscle weakness, lack of co-ordination, change in personality, faintness, weakness, tremor, palpitations, sweating, hunger and nervousness.
- Symptoms of depression?
Why: e.g. depressed mood, crying spells, anhedonia (loss of interest or pleasure), increase or decrease in appetite (usually decreased), weight loss or gain, insomnia or increased sleeping (usually early morning waking), fatigue, loss of energy, feelings of worthlessness, feelings of excessive guilt, poor concentration, difficulty making decisions, low libido, thoughts of death or suicide attempt. Overeating may be a feature of depression, especially in the early stages.
- Symptoms of obstructive sleep apnea?
Why: e.g. loud snoring, daytime sleepiness and fatigue, unrefreshed sleep, restless sleep, morning headache, nocturnal choking, reduced libido. Obstructive sleep apnea is often a consequence of obesity.
- Symptoms of polycystic ovarian syndrome?
Why: e.g. acne, infrequent or absent menstrual periods, excessive hairiness, obesity.
- Symptoms of Klinefelter's syndrome?
Why: e.g. only affects males, excessive growth of the long bones of the arms and legs. The boys are tall and slim but without testosterone treatment they become obese as adults.
- Symptoms of Laurence-Moon-Bardet-Biedl syndrome?
Why: e.g. congenital disorder with characteristic features of obesity, mental retardation, webbing or fusing of fingers or toes, extra fingers or toes, small genitals, visual problems.
- Symptoms of Prader-Willi syndrome?
Why: e.g. congenital disorder with characteristic features of bizarre eating habits (such as binge eating), obesity, lack of muscle tone in the limbs, small genitals, mental retardation, small hands, small feet, narrow forehead, "almond-shaped" eyes, "tented" upper lip.
- Symptoms of Beckwirth-Wiedemann syndrome?
Why: e.g. congenital disorder with characteristic features of obesity, excessive growth, large head, large tongue, hernia around the umbilicus. Intelligence is in the normal range.