Prevalence and Incidence of Tay Sachs
Prevalance of types of Tay Sachs:
For details see prevalence of types of Tay Sachs analysis; summary of available prevalence data:
Tay Sachs Prevalence: Book Excerpts
Prevalence/Incidence of Tay Sachs: Online Medical Books
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Review excerpts from medical books online, free, without registration,
for more information about the prevalence and/or incidence of Tay Sachs.
Tay-Sachs disease:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Tay-Sachs disease (also known as GM2 gangliosidosis) is an autosomal recessive disorder of chromosome 15 in which the enzyme hexosaminidase A is virtually absent or deficient. This enzyme is necessary for metabolism of gangliosides, water-soluble glycolipids found primarily in central nervous system (CNS) tissues. Without hexosaminidase A, accumulating lipid pigments distend and progressively destroy and demyelinate CNS cells.
Tay-Sachs disease appears in fewer than 100 neonates born each year in the United States. However, about it's 100 times more common in persons of Eastern European Jewish (Ashkenazi) ancestry than in the general population, occurring in about l in 3,600 live births in this ethnic group. About 1 in 30 Ashkenazi Jews, French Canadians, and American Cajuns are heterozygous carriers. If two such carriers have children, each of their offspring has a 25% chance of having Tay-Sachs disease.
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Source: Professional Guide to Diseases (Eighth Edition), 2005
About prevalence and incidence statistics:
The term 'prevalence' of Tay Sachs usually refers to the estimated population
of people who are managing Tay Sachs at any given time.
The term 'incidence' of Tay Sachs refers to the annual diagnosis rate,
or the number of new cases of Tay Sachs diagnosed each year.
Hence, these two statistics types can differ:
a short-lived disease like flu can have high annual incidence but low prevalence,
but a life-long disease like diabetes has a low annual incidence but high prevalence.
For more information see about prevalence and incidence statistics.
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