Clinical Trials for Tourette Syndrome

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Tourette Syndrome is grouped into the following categories:-

• View by trial name
• View by drugs used in Tourette Syndrome clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Tourette Syndrome:

• Magnetic Resonance Spectroscopy to Evaluate Tourette's Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Tics in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder - This study is no longer recruiting patients (Current: 23 Nov 2006) - [O15] Water
• Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - flumazenil,H215O
• Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hypersensitivity in Tourette Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents - This study has been completed (Current: 23 Nov 2006)
• Study of the Neurobiology of Tourette Syndrome and Related Disorders - This study has been completed (Current: 23 Nov 2006)
• Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder - This study has been completed (Current: 23 Nov 2006) - guanfacine
• Phase II Double Blind Placebo Controlled Trial of Risperidone in Tourette Syndrome - This study has been completed (Current: 23 Nov 2006) - risperidone
• Randomized Study of Pergolide in Children With Tourette Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - pergolide
• Phase II Pilot Controlled Study of Short Vs Longer Term Pimozide (Orap) Therapy in Tourette Syndrome - This study has been completed (Current: 23 Nov 2006) - pimozide
• Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder - This study is currently recruiting patients (Current: 23 Nov 2006)
• Thalamic Deep Brain Stimulation for Tourette Syndrome - This study has been completed (Current: 23 Nov 2006)
• Comparison of Keppra and Clonidine in the Treatment of Tics - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - levetiracetam and clonidine
• Brain Tissue Collection for Neuropathological Studies - This study is currently recruiting patients (Current: 23 Nov 2006)
• Central Mechanisms in Speech Motor Control Studied With H215O PET - This study is currently recruiting patients (Current: 23 Nov 2006) - Radioactive Water
• I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers - This study has been completed (Current: 23 Nov 2006)
• Brain Activation in Vocal and Motor Tics - This study has been completed (Current: 23 Nov 2006)
• High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome - This study has been completed (Current: 23 Nov 2006)
• Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - APO-clonidine
• Safety Study of Galantamine in Tic Disorders - This study is currently recruiting patients (Current: 23 Nov 2006) - galantamine
• Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder - This study is currently recruiting patients (Current: 23 Nov 2006) - Aripiprazole
• Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions - This study is currently recruiting patients (Current: 23 Nov 2006)
• Brain Activity Associated With Tics in Patients With Tourette Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• National Gilles De La Tourette Study Group - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Randomized, Placebo-Controlled, Tourette Syndrome Study. - This study is currently recruiting patients (Current: 23 Nov 2006) - Topiramate (drug)
• An Open-Label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome. - This study is currently recruiting patients (Current: 23 Nov 2006) - Topiramate (drug)
• Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effectiveness of Psychosocial Therapy for the Treatment of Tourette Syndrome and Chronic Tic Disorder - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Aripiprazole in the Treatment of Tourette's Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - Aripiprazole
• Treatment of Obsessive-Compulsive Disorder - This study has been completed (Current: 23 Nov 2006) - Fluoxetine,Olanzapine
• Cortical Excitability in Obsessive-Compulsive and Related Disorders - This study has been completed (Current: 23 Nov 2006)
• Genetics of Obsessive-Compulsive Disorder - This study is currently recruiting patients (Current: 23 Nov 2006)
• Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Tourette Syndrome

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Tourette Syndrome:

• APO-clonidine - Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Aripiprazole - Aripiprazole in the Treatment of Tourette's Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Aripiprazole - Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder - This study is currently recruiting patients (Current: 23 Nov 2006)
• Flumazenil - Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fluoxetine - Treatment of Obsessive-Compulsive Disorder - This study has been completed (Current: 23 Nov 2006)
• Galantamine - Safety Study of Galantamine in Tic Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
• Guanfacine - Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder - This study has been completed (Current: 23 Nov 2006)
• H215O - Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levetiracetam And Clonidine - Comparison of Keppra and Clonidine in the Treatment of Tics - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Olanzapine - Treatment of Obsessive-Compulsive Disorder - This study has been completed (Current: 23 Nov 2006)
• Pergolide - Randomized Study of Pergolide in Children With Tourette Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pimozide - Phase II Pilot Controlled Study of Short Vs Longer Term Pimozide (Orap) Therapy in Tourette Syndrome - This study has been completed (Current: 23 Nov 2006)
• Radioactive Water - Central Mechanisms in Speech Motor Control Studied With H215O PET - This study is currently recruiting patients (Current: 23 Nov 2006)
• Risperidone - Phase II Double Blind Placebo Controlled Trial of Risperidone in Tourette Syndrome - This study has been completed (Current: 23 Nov 2006)
• Topiramate (drug) - A Randomized, Placebo-Controlled, Tourette Syndrome Study. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Topiramate (drug) - An Open-Label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome. - This study is currently recruiting patients (Current: 23 Nov 2006)
• [O15] Water - Study of Tics in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder - This study is no longer recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov