A rare chromosomal genetic syndrome with one or more extra X chromosomes, leading to XXX (or more rarely XXXX or XXXXX), instead of the usual XX (female) or XY (male). These people are females as they have no Y male chromosome, but have an additional female X chromosome. Women can be largely unaffected, or may suffer from problems such as infertility (some but not all), and reduced mental acuity.
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A rare chromosomal aberration characterized by the presence of three X (female) chromosomes. The condition does not exhibit a distinctive phenotype and majority of the affected females are physically and mentally normal. Abnormalities are infrequent and do not occur with any regularity--they include hypertelorism, epicanthal folds, depressed nasal bridge, kyphosis and variable other anomalies. Delay in growth and mental development, when present, is usually mild. Occasionally associated with Prader-Willi syndrome. - (Source - Diseases Database)
Triple-X syndrome is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Triple-X syndrome, or a subtype of Triple-X syndrome,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Triple-X syndrome as a "rare disease".
Source - Orphanet
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