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Diseases » Typhoid fever » Research

Cure Research for Typhoid fever

Treatments for Typhoid fever

Treatments to consider for Typhoid fever may include:

Medical Research Breakthroughs and Typhoid fever

Single oral dose of Ty800 vaccine: Ty800, a typhoid fever vaccine has met all primary endpoints in a double-blind, placebo-controlled multi-centre Phase 2 clinical trial. This vaccine developed by a company called AVANT Immunotherapeutics offers rapid, oral, single-dose protection against Salmonella typhi, the cause of typhoid fever. The Ty800 vaccine was developed by deleting specific genes known to be essential to the virulence of S. typhi. The clinical trial conducted on 183 healthy volunteers, evaluated two dose levels of the vaccine and followed each subject for six months following vaccination. According to the data gathered from the trial, the single-dose, oral vaccine was well tolerated and immunogenic. Adverse events post-vaccination were similar to placebo. The immunogenic response was dose-dependent and the positive immune response or seroconversion (prospectively defined as a 4-fold increase in anti-LPS titres over pre-dose level) rates were 65.5% (36/55) and 80% (44/55) in the low and high dose groups, respectively. The vaccines currently available in the market for typhoid are either single dose injections or multiple oral doses. Hence there was a requirement for a single dose oral vaccine which is efficacious, a void AVANT's Single-Dose Oral Ty800 Vaccine hopes to fill.