Cure Research for Urine retention

Treatments for Urine retention

Treatments to consider for Urine retention may include:

Emergency treatment - for acute urine retention
Treatment of the underlying cause
more treatments...»

Medical Research Breakthroughs and Urine retention

Newer regenerative medical techniques for bladder regeneration: According to a new study, conducted in large mammals, by researchers from Tengion Inc, bladder regeneration via a neo-bladder replacement may prove to be effective in humans. The results of this study which were presented at the 103rd Annual Scientific Meeting of the American Urological Association (AUA) suggest that this process could result in a regenerated bladder with similar characteristics of the native bladder and without the risks associated with a donated organ or other undesirable outcomes associated with current surgical interventions. Patients with advanced bladder disease often require cystectomy (removal of the bladder). Replacement bladders made from intestinal tissue have been proven to be successful but have also been associated with many well documented complications, such as chronic urinary retention, hematuria and infection. Hence growing a replacement organ for a patient using his or her own cells presents a new option. After a bladder biopsy is obtained from a patient, bladder progenitor cells are grown in culture and seeded on a biodegradable bladder-shaped scaffold made from collagen and/or polyglycolic acid. The neo-organ is then implanted into the patient. In the study, fourteen large mammals that underwent radical cystectomy were implanted with the neo-bladder construct and within six months, structure and pharmacological characteristics of the neo-bladder were similar to the native bladder. There was no evidence of abnormal tissue development, immune response or evidence of systemic response to the neo-bladder regeneration. Results suggest that the new organ had successfully and safely regenerated. This treatment option essentially regenerates the patient's own bladder, reducing the risk of rejection and the need for immunosuppressant drugs. If successful in human clinical trials, patients should expect to regenerate normal bladder structure and function.