Autosomal dominant diseases are usually inherited from the one parent who already has the disease. Rare cases of sporadic genetic disease with neither parent having the disease can also occur. See inheritance of autosomal dominant diseases.
Inheritance properties of Von Hippel-Lindau Disease: Disease inherited from: Usually inherited from one parent who has Von Hippel-Lindau Disease; see inheritance of autosomal dominant diseases.
Gender bias in inheritance: Male and female children are equally at risk of autosomal dominant diseases.
Inheritance odds for Von Hippel-Lindau Disease: Overall odds of inheritance: Usually inherited from one parent who has Von Hippel-Lindau Disease; see inheritance of autosomal dominant diseases.
Sibling of diseased child odds of inheriting disease: Usually 50% for autosomal dominant diseases.
Overall odds of inheriting from mother: Usually 50% for autosomal dominant diseases.
Overall odds of inheriting from father: Usually 50% for autosomal dominant diseases. Mother to son inheritance odds: Usually 50% for autosomal dominant diseases.
Father to son inheritance odds: Usually 50% for autosomal dominant diseases.
Mother to daughter inheritance odds: Usually 50% for autosomal dominant diseases.
Father to daughter inheritance odds: Usually 50% for autosomal dominant diseases.
Inheritance from one diseased parent odds: Usually 50% for autosomal dominant diseases.
Inheritance from two diseased parents odds: Usually 75% (50% disease, 25% double dominant) for autosomal dominant diseases.
Genetic carriers of Von Hippel-Lindau Disease: Carriers possible for disease?: No, not for autosomal dominant diseases.
Odds daughter becomes genetic carrier: 0%. There are no carriers for autosomal dominant diseases.
Odds son becomes genetic carrier: 0%. There are no carriers for autosomal dominant diseases.
Inheritance features for Von Hippel-Lindau Disease: Inheritance pattern: Vertical inheritance for autosomal dominant disease.
Sporadic form of disease possible?: Yes, only one genetic mutation is required for a sporadic version of an autosomal dominant disease.
Double dominant form of disease possible?: Yes, double dominance is definitely applicable for autosomal dominance.
Inheritance from one double dominant parent: Usually 100% inheritance from a double dominant form of an autosomal dominant disease.
Genetics of Von Hippel-Lindau Disease: The gene for Von-Hippel Lindau disease (VHL) is found on chromosome 3, and is inherited in a dominant fashion. If one parent has a dominant gene, each child has a 50-50 chance of inheriting that gene. The VHL gene is a tumor suppressor gene. This means that its role in a normal cell is to stop uncontrolled growth and proliferation. If the gene is lost or mutated, then its inhibitory effect on cell growth is lost or diminished, which, in combination with defects in other regulatory proteins, can lead to cancerous growth. LIke the Rb tumor suppressor gene, VHL seems to act as a 'gatekeeper' to the multistep process of tumorigenesis. (Source: Genes and Disease by the National Center for Biotechnology)
Inheritance of Von Hippel-Lindau Disease refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.
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