Prevalence and Incidence of Von Willebrand disease
Prevalance of Von Willebrand disease:
estimated 3 million mostly undiagnosed ... see also overview of Von Willebrand disease.
Prevalance Rate:
approx 1 in 90 or 1.10% or 3 million people in USA [Source statistic for calcuation: "estimated 3 million mostly undiagnosed" -- see also general information about data sources]
Von Willebrand disease: Rare Disease
Von Willebrand disease is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Von Willebrand disease, or a subtype of Von Willebrand disease,
affects less than 200,000 people in the US population.
Ophanet, who are a consortium of European partners,
currently defines a condition rare when if affects 1 person per 2,000.
They list Von Willebrand disease as a "rare disease".
More information about Von Willebrand disease is available from Orphanet
Von Willebrand disease Prevalence: Book Excerpts
Undiagnosed prevalence of Von Willebrand disease:
estimated 1 million undiagnosed US women with Von Willebrand disease ... see also misdiagnosis of Von Willebrand disease.
Undiagnosed prevalence rate:
approx 1 in 272 or 0.37% or 1 million people in USA [about data] ... Note: this rate calculation uses the following statistic: estimated 1 million undiagnosed US women with Von Willebrand disease
Prevalence/Incidence of Von Willebrand disease: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the prevalence and/or incidence of Von Willebrand disease.
Von Willebrand's disease:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Unlike hemophilia, von Willebrand’s disease is inherited as an autosomal dominant trait that affects males and females equally. One theory of pathophysiology holds that mild to moderate deficiency of factor VIII and defective platelet adhesion prolong coagulation time. Specifically, this results from a deficiency of the vWF, which stabilizes the factor VIII molecule and is needed for proper platelet function.
Defective platelet function is characterized by:
❑ decreased agglutination and adhesion at the bleeding site
❑ reduced platelet retention when filtered through a column of packed glass beads
❑ diminished ristocetin-induced platelet aggregation.
Recently, an acquired form has been identified in patients with cancer and immune disorders.
Von Willebrand’s disease, which doesn’t have any racial or ethnic associations, affects about 1% of the population.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Von Willebrand Disease:
Von Willebrand Disease - epidemiology
(The 5-Minute Pediatric Consult)
Males and females are equally affected.
Von Willebrand Disease - prevalence
The prevalence of von Willebrand disease in the general pediatric population is estimated to be ~1%.
» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
About prevalence and incidence statistics:
The term 'prevalence' of Von Willebrand disease usually refers to the estimated population
of people who are managing Von Willebrand disease at any given time.
The term 'incidence' of Von Willebrand disease refers to the annual diagnosis rate,
or the number of new cases of Von Willebrand disease diagnosed each year.
Hence, these two statistics types can differ:
a short-lived disease like flu can have high annual incidence but low prevalence,
but a life-long disease like diabetes has a low annual incidence but high prevalence.
For more information see about prevalence and incidence statistics.
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