Diseases » Wegener's granulomatosis » Clinical Trials

Clinical Trials for Wegener's granulomatosis

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Wegener's granulomatosis is grouped into the following categories:-

View by trial name

View by drugs used in Wegener's granulomatosis clinical trials

Clinical Trials by trial name

The format for each of the following is:

The name of the trial,
followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Wegener's granulomatosis:

Daclizumab to Treat Wegener's Granulomatosis - This study has been completed (Current: 23 Nov 2006) - Daclizumab
Treatment of Wegener's Granulomatosis With Cyclophosphamide - This study has been completed (Current: 23 Nov 2006)
Cyclophosphamide and Prednisone Followed by Methotrexate To Treat Vasculitides - This study has been completed (Current: 23 Nov 2006)
Diagnostic Effectiveness of Virtual Bronchoscopy - This study has been completed (Current: 23 Nov 2006)
Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis - This study has been completed (Current: 23 Nov 2006)
Assessment of Lung Inflammation in Patients With Atopic Asthma Using Positron Emission Tomography - This study has been completed (Current: 23 Nov 2006)
Phase I Trial of Recombinant Human Interleukin-10 (SCH 52000) in Patients With Wegener's Granulomatosis - This study has been completed (Current: 23 Nov 2006)
Mycophenolate Mofetil to Treat Wegener's Granulomatosis and Related Vascular Inflammatory Conditions - This study has been completed (Current: 23 Nov 2006) - Mycophenolate Mofetil
Etanercept to Treat Wegener's Granulomatosis - This study has been completed (Current: 23 Nov 2006) - Etanercept
Comparison of Treatments to Maintain Disease Remission in Patients With Wegener's Granulomatosis and Related Vasculitis Syndromes - This study has been completed (Current: 23 Nov 2006) - Mycophenolate Mofetil
Etanercept for Wegener's Granulomatosis - This study is no longer recruiting patients (Current: 23 Nov 2006) - Etanercept
Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases - This study is no longer recruiting patients (Current: 23 Nov 2006) - anti-thymocyte globulin,cyclophosphamide,cyclosporine,filgrastim,methylprednisolone,prednisone
Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) - This study is currently recruiting patients (Current: 23 Nov 2006) - mycophenolate mofetil
Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Rituximab,Cyclophosphamide,Azathioprine,Methylprednisolone (or other glucocorticoid),Prednisone
An Open Label Pilot Study Examining the Use of Rituximab in Patients With Wegener's Granulomatosis Who Have Experienced Disease Relapse on Standard Therapies - This study has been completed (Current: 23 Nov 2006) - Rituximab
Steroids and Methotrexate to Treat Systemic Vasculitis - This study has been completed (Current: 23 Nov 2006)
Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol. - This study has been completed (Current: 23 Nov 2006) - Alendronate versus alfacalcidol (1-alpha OH vitamin D)
RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides - This study is currently recruiting patients (Current: 23 Nov 2006) - Infliximab,Rituximab
Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years - This study is currently recruiting patients (Current: 23 Nov 2006) - Corticosteroids (prednisone, methylprednisolone),Cyclophosphamide,Azathioprine,Mycophenolate mofetil
Determining Disease Activity Biomarkers in Individuals With Wegener's Granulomatosis and Microscopic Polyangiitis - This study is currently recruiting patients (Current: 23 Nov 2006)
WEGENT Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides - This study is no longer recruiting patients (Current: 23 Nov 2006) - Azathioprine: 2 mg/kg/day,methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
Prevention of Relapses in Proteinase 3 (PR3)-Anti-Neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis - This study is currently recruiting patients (Current: 23 Nov 2006) - azathioprine

Drugs used in Clinical Trials for Wegener's granulomatosis

The format for each of the following is:

The drug,
followed by the name of the trial,
followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Wegener's granulomatosis: