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Diseases » Weight Gain » Causes
 

Causes of Weight Gain

Causes of Weight Gain (Diseases Database):

The follow list shows some of the possible medical causes of Weight Gain that are listed by the Diseases Database:

Source: Diseases Database

Weight Gain Causes: Book Excerpts

Weight Gain as a complication of other conditions:

Other conditions that might have Weight Gain as a complication may, potentially, be an underlying cause of Weight Gain. Our database lists the following as having Weight Gain as a complication of that condition:

Weight Gain as a symptom:

Conditions listing Weight Gain as a symptom may also be potential underlying causes of Weight Gain. Our database lists the following as having Weight Gain as a symptom of that condition:

Medications or substances causing Weight Gain:

The following drugs, medications, substances or toxins are some of the possible causes of Weight Gain as a symptom. This list is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.

See full list of 454 medications causing Weight Gain


Drug interactions causing Weight Gain:

When combined, certain drugs, medications, substances or toxins may react causing Weight Gain as a symptom.

The list below is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.

  • Aldactazide (Spironolactone, HCTZ) and Advil (Ibuprofen) interaction - Sudden weight gain
  • Aldactazide (Spironolactone, HCTZ) and Motrin (Ibuprofen) interaction - Sudden weight gain
  • Aldactazide (Spironolactone, HCTZ) and Nuprin (Ibuprofen) interaction - Sudden weight gain
  • Aldactazide (Spironolactone, HCTZ) and Aleve (Naproxen) interaction - Sudden weight gain
  • Aldactazide (Spironolactone, HCTZ) and Naprosyn (Naproxen) interaction - Sudden weight gain
  • more interactions...»

See full list of 222 drug interactions causing Weight Gain

Medical news summaries relating to Weight Gain:

The following medical news items are relevant to causes of Weight Gain:

Related information on causes of Weight Gain:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Weight Gain may be found in:

Causes of Weight Gain: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Weight Gain.

Weight Gain: Differential Diagnosis
(In a Page: Signs and Symptoms)

  • Primary obesity due to overeating and a sedentary lifestyle
  • Medication side effects (e.g., oral contraceptives, corticosteroids, antidepressants, benzodiazepines, hypoglycemics, and anticonvulsants)
  • Overeating secondary to nicotine withdrawal, depression, binge phase of bulimia nervosa
  • Pregnancy
  • Pre-eclampsia/eclampsia
  • Premenstrual syndrome
  • Nephrotic syndrome
    –Renal loss of protein results in decreased intravascular oncotic pressure, leading to water “leakage” to extravascular compartments (e.g., edema, ascites)
    –Due to primary renal disease or secondary causes (e.g., diabetes mellitus)
  • Acute or chronic liver disease
    –Decreased hepatic protein production results in decreased intravascular oncotic pressure, leading to water “leakage” to extravascular compartments (e.g., edema, ascites)
  • Congestive heart failure
  • Hypothyroidism
  • Diabetes mellitus
    • Polycystic ovarian syndrome
      –Associated with hirsutism, menstrual irregularities, insulin resistance, obesity
    • Cushing's syndrome
      –Excess cortisol levels due to ACTH-secreting adrenal adenoma, adrenal hyperplasia, ACTH-secreting ectopic tumor, or ACTH-secreting pituitary adenoma (Cushing's disease)
    • Less common etiologies (“zebras”) include hypothalamic lesions (e.g., tumor, infection), hyperphagia due to hyperthyroidism, acromegaly (growth hormone excess, usually due to a pituitary tumor), or growth hormone deficiency

» READ BOOK EXCERPT ONLINE »

Source: In a Page: Signs and Symptoms, 2004

Weight gain, excessive: Medical causes
(Handbook of Signs & Symptoms (Third Edition))

Acromegaly

Acromegaly causes moderate weight gain. Other findings include coarsened facial features, prognathism, enlarged hands and feet, increased sweating, oily skin, deep voice, back and joint pain, lethargy, sleepiness, and heat intolerance. Occasionally, hirsutism may occur.

Diabetes mellitus

The increased appetite associated with diabetes mellitus may lead to weight gain, although weight loss sometimes occurs instead. Other findings include fatigue, polydipsia, polyuria, nocturia, weakness, polyphagia, and somnolence.

Hypercortisolism

Excessive weight gain, usually over the trunk and the back of the neck (buffalo hump), characteristically occurs in this disorder. Other cushingoid features include slender extremities, moon face, weakness, purple striae, emotional lability, and increased susceptibility to infection. Gynecomastia may occur in men; hirsutism, acne, and menstrual irregularities may occur in women.

Hyperinsulinism

Hyperinsulinism increases appetite, leading to weight gain. Emotional lability, indigestion, weakness, diaphoresis, tachycardia, visual disturbances, and syncope also occur.

Hypogonadism

Weight gain is common in hypogonadism. Prepubertal hypogonadism causes eunuchoid body proportions with relatively sparse facial and body hair and a high-pitched voice. Postpubertal hypogonadism causes loss of libido, impotence, and infertility.

Hypothalamic dysfunction

Conditions such as Laurence-Moon-Biedl syndrome cause a voracious appetite with subsequent weight gain, along with altered body temperature and sleep rhythms.

Hypothyroidism

With hypothyroidism, weight gain occurs despite anorexia. Related signs and symptoms include fatigue; cold intolerance; constipation; menorrhagia; slowed intellectual and motor activity; dry, pale, cool skin; dry, sparse hair; and thick, brittle nails. Myalgia, hoarseness, hypoactive deep tendon reflexes, bradycardia, and abdominal distention may occur. Eventually, the face assumes a dull expression with periorbital edema.

Nephrotic syndrome

With nephrotic syndrome, weight gain results from edema. In severe cases, anasarca develops — increasing body weight up to 50%. Related effects include abdominal distention, orthostatic hypotension, and lethargy.

Pancreatic islet cell tumor

Pancreatic islet cell tumor causes excessive hunger, which leads to weight gain. Other findings include emotional lability, weakness, malaise, fatigue, restlessness, diaphoresis, palpitations, tachycardia, visual disturbances, and syncope.

Preeclampsia

With preeclampsia, rapid weight gain (exceeding the normal weight gain of pregnancy) may accompany nausea and vomiting, epigastric pain, elevated blood pressure, and visual blurring or double vision.

Sheehan’s syndrome

Most common in women who experience severe obstetric hemorrhage, Sheeehan’s syndrome may cause weight gain.

Other causes

Drugs

Corticosteroids, phenothiazines, and tricyclic antidepressants cause weight gain from fluid retention and increased appetite. Other drugs that can lead to weight gain include hormonal contraceptives, which cause fluid retention; cyproheptadine, which increases appetite; and lithium, which can induce hypothyroidism.

» READ BOOK EXCERPT ONLINE »

Source: Handbook of Signs & Symptoms (Third Edition), 2006

Weight gain, excessive: Medical causes
(Professional Guide to Signs & Symptoms (Fifth Edition))

Acromegaly

This disorder causes moderate weight gain. Other findings include coarsened facial features, prognathism, enlarged hands and feet, increased sweating, oily skin, deep voice, back and joint pain, lethargy, sleepiness, heat intolerance and, occasionally, hirsutism.

Cushing’s syndrome (hypercortisolism)

Excessive weight gain, usually over the trunk and the back of the neck (buffalo hump), characteristically occurs in this disorder. Other cushingoid features include slender extremities, moon face, weakness, purple striae, emotional lability, and increased susceptibility to infection. Gynecomastia may occur in men; hirsutism, acne, and menstrual irregularities may occur in women.

Diabetes mellitus

The increased appetite associated with this disorder may lead to weight gain, although weight loss sometimes occurs instead. Other findings include fatigue, polydipsia, polyuria, nocturia, weakness, polyphagia, and somnolence.

Heart failure

Despite anorexia, weight gain may result from edema. Other typical findings include paroxysmal nocturnal dyspnea, orthopnea, and fatigue.

Hyperinsulinism

This disorder increases appetite, leading to weight gain. Emotional lability, indigestion, weakness, diaphoresis, tachycardia, visual disturbances, and syncope also occur.

Hypogonadism

Weight gain is common in this disorder. Prepubertal hypogonadism causes eunuchoid body proportions with relatively sparse facial and body hair and a high-pitched voice. Postpubertal hypogonadism causes loss of libido, impotence, and infertility.

Hypothalamic dysfunction

Conditions such as Laurence-Moon-Biedl syndrome cause a voracious appetite and subsequent weight gain along with altered body temperature and sleep rhythms.

Hypothyroidism

In this disorder, weight gain occurs despite anorexia. Related signs and symptoms include fatigue; cold intolerance; constipation; menorrhagia; slowed intellectual and motor activity; dry, pale, cool skin; dry, sparse hair; and thick, brittle nails. Myalgia, hoarseness, hypoactive deep tendon reflexes, bradycardia, and abdominal distention may occur. Eventually, the face assumes a dull expression with periorbital edema.

Metabolic syndrome

This syndrome, previously called syndrome X, consists of a group of disorders that affect metabolism, including excessive weight gain (usually in the central abdomen), hypertension (blood pressure greater than 135/85 mm Hg), abnormal cholesterol levels (high low-density lipoprotein and triglyceride levels, low high-density lipoprotein level), and high insulin levels. Inefficient use of insulin in the body is thought to be a major contributor to metabolic syndrome, as are physical inactivity, poor diet, and genetic factors. Individuals with metabolic syndrome are at a significantly increased risk for heart disease, stroke, and diabetes. Treatment typically involves exercising, following a heart-healthy diet, and refraining from smoking; medical therapy may be prescribed to treat the individual disorders.

Nephrotic syndrome

In this syndrome, weight gain results from edema. Severe edema (anasarca) can increase body weight by up to 50%. Related effects include abdominal distention, orthostatic hypotension, and lethargy.

Pancreatic islet cell tumor

This type of tumor causes excessive hunger, which leads to weight gain. Other findings include emotional lability, weakness, malaise, fatigue, restlessness, diaphoresis, palpitations, tachycardia, visual disturbances, and syncope.

Preeclampsia

In this disorder, rapid weight gain (exceeding the normal weight gain of pregnancy) may accompany nausea and vomiting, epigastric pain, elevated blood pressure, and blurred or double vision.

Sheehan’s syndrome

Most common in women who experience severe obstetric hemorrhage, this syndrome may cause weight gain caused by impaired pituitary gland function.

Other causes

Drugs

Corticosteroids, phenothiazines, and tricyclic antidepressants cause weight gain from fluid retention and increased appetite. Other drugs that can lead to weight gain include hormonal contraceptives, which cause fluid retention; cyproheptadine, which increases appetite; and lithium, which can induce hypothyroidism.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Signs & Symptoms (Fifth Edition), 2006

Weight gain, excessive: Medical causes
(Signs & Symptoms: A 2-in-1 Reference for Nurses)

Acromegaly

Acromegaly causes moderate weight gain. Other findings include coarsened facial features, prognathism, enlarged hands and feet, increased sweating, oily skin, deep voice, back and joint pain, lethargy, sleepiness, and heat intolerance. Occasionally, hirsutism may occur.

Diabetes mellitus

The increased appetite associated with diabetes mellitus may lead to weight gain, although weight loss sometimes occurs instead. Other findings include fatigue, polydipsia, polyuria, nocturia, weakness, polyphagia, and somnolence.

Heart failure

Despite anorexia, weight gain may result from edema. Other typical findings in heart failure include paroxysmal nocturnal dyspnea, tachypnea, tachycardia, nausea, orthopnea, and fatigue.

Hypercortisolism

Excessive weight gain, usually over the trunk and the back of the neck (buffalo hump), characteristically occurs in hypercortisolism. Other cushingoid features include slender extremities, moon face, weakness, purple striae, emotional lability, and increased susceptibility to infection. Gynecomastia may occur in men; hirsutism, acne, and menstrual irregularities may occur in women.

Hyperinsulinism

Hyperinsulinism increases appetite, leading to weight gain. Emotional lability, indigestion, weakness, diaphoresis, tachycardia, vision disturbances, and syncope also occur.

Hypogonadism

Weight gain is common in hypogonadism. Prepubertal hypogonadism causes eunuchoid body proportions with relatively sparse facial and body hair and a high-pitched voice. Postpubertal hypogonadism causes loss of libido, impotence, and infertility.

Hypothyroidism

With hypothyroidism, weight gain occurs despite anorexia. Related signs and symptoms include fatigue; cold intolerance; constipation; menorrhagia; slowed intellectual and motor activity; dry, pale, cool skin; dry, sparse hair; and thick, brittle nails. Myalgia, hoarseness, hypoactive deep tendon reflexes, bradycardia, and abdominal distention may occur. Eventually, the face assumes a dull expression with periorbital edema.

Nephrotic syndrome

With nephrotic syndrome, weight gain results from edema. In severe cases, anasarca develops — increasing body weight up to 50%. Related effects include abdominal distention, orthostatic hypotension, and lethargy.

Pancreatic islet cell tumor

Pancreatic islet cell tumor causes excessive hunger, which leads to weight gain. Other findings include emotional lability, weakness, malaise, fatigue, restlessness, diaphoresis, palpitations, tachycardia, vision disturbances, and syncope.

Preeclampsia

With preeclampsia, rapid weight gain (exceeding the normal weight gain of pregnancy) may accompany nausea and vomiting, epigastric pain, elevated blood pressure, and visual blurring or double vision.

Other causes

Drugs

Corticosteroids, phenothiazines, and tricyclic antidepressants cause weight gain from fluid retention and increased appetite. Other drugs that can lead to weight gain include hormonal contraceptives, which cause fluid retention; cyproheptadine, which increases appetite; and lithium, which can induce hypothyroidism.

» READ BOOK EXCERPT ONLINE »

Source: Signs & Symptoms: A 2-in-1 Reference for Nurses, 2007

Weight gain, excessive: Medical causes
(Nursing: Interpreting Signs and Symptoms)

Acromegaly.Acromegaly causes moderate weight gain. Other findings include coarsened facial features, prognathism, enlarged hands and feet, increased sweating, oily skin, deep voice, back and joint pain, lethargy, sleepiness, and heat intolerance. Occasionally, hirsutism may occur.

Diabetes mellitus.The increased appetite associated with diabetes mellitus may lead to weight gain, although weight loss sometimes occurs initially. Other findings include fatigue, polydipsia, polyuria, nocturia, weakness, polyphagia, and somnolence.

Hypercortisolism.Excessive weight gain, usually over the trunk and the back of the neck (buffalo hump), characteristically occurs in hypercortisolism. Other cushingoid features include slender extremities, moon face, weakness, purple striae, emotional lability, and increased susceptibility to infection. Gynecomastia may occur in men; hirsutism, acne, and menstrual irregularities may occur in women.

Hyperinsulinism.Hyperinsulinism increases appetite, leading to weight gain. Emotional lability, indigestion, weakness, diaphoresis, tachycardia, vision disturbances, and syncope also occur.

Hypogonadism.Weight gain is common in hypogonadism. Prepubertal hypogonadism causes eunuchoid body proportions with relatively sparse facial and body hair and a high-pitched voice. Postpubertal hypogonadism causes loss of libido, impotence, and infertility.

Hypothalamic dysfunction.Conditions such as Laurence-Moon-Biedl syndrome cause a voracious appetite with subsequent weight gain, along with altered body temperature and sleep rhythms.

Hypothyroidism.With hypothyroidism, weight gain occurs despite anorexia. Related signs and symptoms include fatigue; cold intolerance; constipation; menorrhagia; slowed intellectual and motor activity; dry, pale, cool skin; dry, sparse hair; and thick, brittle nails. Myalgia, hoarseness, hypoactive deep tendon reflexes, bradycardia, and abdominal distention may occur. Eventually, the face assumes a dull expression with periorbital edema.

Metabolic syndrome.Metabolic syndrome, previously called syndrome X, consists of a group of disorders that affect metabolism, including excessive weight gain (usually in the central abdomen), hypertension (blood pressure greater than 135/85 mm Hg), abnormal cholesterol levels (high low-density lipoprotein and triglyceride levels, low high-density lipoprotein level), and high insulin levels.

Nephrotic syndrome.With nephrotic syndrome, weight gain results from edema. In severe cases, anasarca develops—increasing body weight up to 50%. Related effects include abdominal distention, orthostatic hypotension, and lethargy.

Pancreatic islet cell tumor.Pancreatic islet cell tumor causes excessive hunger, which leads to weight gain. Other findings include emotional lability, weakness, malaise, fatigue, restlessness, diaphoresis, palpitations, tachycardia, vision disturbances, and syncope.

Preeclampsia.With preeclampsia, rapid weight gain (exceeding the normal weight gain of pregnancy) may accompany nausea and vomiting, epigastric pain, elevated blood pressure, and blurred or double vision.

Sheehan's syndrome.Most common in women who experience severe obstetric hemorrhage, Sheehan's syndrome may cause weight gain.

Other causes

Drugs.Corticosteroids, phenothiazines, and tricyclic antidepressants cause weight gain from fluid retention and increased appetite. Other drugs that can lead to weight gain include hormonal contraceptives, which cause fluid retention; cyproheptadine, which increases appetite; and lithium, which can induce hypothyroidism.

» READ BOOK EXCERPT ONLINE »

Source: Nursing: Interpreting Signs and Symptoms, 2007

Poor Weight Gain - Case 6-1: 16-Month-Old Boy: I. Differential Diagnosis
(Pediatric Complaints and Diagnostic Dilemmas)

There were many possible diagnoses to consider in this case. In the general categorization of organic versus nonorganic causes of FTT, the symptoms of diarrhea and later fever were factors supporting an organic cause. Yet, the family history of being noncompliant with getting the nutritional supplements and the fact that this was an overstressed family, with an HIV-positive mother and twin babies, raises some nonorganic factors. The possibility of mixed FTT was very high on the list. As far as organic causes, HIV is a well-known cause of FTT. It is sometimes difficult to distinguish between maternally acquired antibodies and true infection. The positive (times 2) PCR result made true HIV infection one diagnosis. The onset of high spiking fevers then prompted the evaluation for an opportunistic infection.
Diagnostic considerations in an HIV-infected child with fever are diverse. Opportunistic diseases and pathogens to consider include Pneumocystis carinii pneumonia, lymphoid interstitial pneumonia (LIP), and cryptococcal infection. Viruses include hepatitis B and C, Epstein-Barr virus, and cytomegalovirus. Other pathogens include M. avium, cryptosporidium, Toxoplasma gondii, and Mycobacterium tuberculosis. Children with HIV are also at risk for focal bacterial infections such as sinusitis, pneumonia, or intraabdominal abscess. A child who is HIV positive and who is febrile requires an exhaustive search to identify an organism.
The initial evaluation should include a search for focal infection and a general assessment of severity of illness. The absence of specific localizing signs presents a greater diagnostic dilemma.

» READ BOOK EXCERPT ONLINE »

Source: Pediatric Complaints and Diagnostic Dilemmas, 2003

Poor Weight Gain - Case 6-2: 7-Month-Old Boy: I. Differential Diagnosis
(Pediatric Complaints and Diagnostic Dilemmas)

The differential diagnosis of growth failure due to malabsorption is a long one. Once the type of malabsorption was narrowed down to exocrine pancreatic dysfunction, then the differential narrowed to hereditary and acquired causes. The hereditary causes include cystic fibrosis, Shwachman-Diamond syndrome, Pearson 's pancreatitis and bone marrow syndrome, and isolated enzyme deficiency. Acquired causes include chronic pancreatic and surgical conditions.
Other causes of malabsorption are many and include defects in the luminal phase, the mucosal phase, or the transport phase of absorption and digestion. Table 6-4 shows tests that may be used to evaluate the various forms of malabsorption.

» READ BOOK EXCERPT ONLINE »

Source: Pediatric Complaints and Diagnostic Dilemmas, 2003

Poor Weight Gain - Case 6-3: 20-Day-Old Girl: I. Differential Diagnosis
(Pediatric Complaints and Diagnostic Dilemmas)

The differential diagnosis in this case was broad. During feeding, the baby was noted to have a poor suck and swallow. There was a question whether this difficulty with intake was a primary problem (e.g., neuropathy, spinal-muscle atrophy) or secondary due to poor nutrition and weakness. When the child was fed, she gained more strength but still failed to gain weight. When no weight gain was noted despite adequate caloric intake, malabsorption was considered.

» READ BOOK EXCERPT ONLINE »

Source: Pediatric Complaints and Diagnostic Dilemmas, 2003

Poor Weight Gain - Case 6-4: 5-Day-Old Boy: I. Differential Diagnosis
(Pediatric Complaints and Diagnostic Dilemmas)

This child presented in heart failure as the cause of his growth failure. The cause of heart failure may be cardiac or noncardiac, as shown in Table 6-9. Table 6-10 shows the differential diagnosis of a liver mass in a child.

» READ BOOK EXCERPT ONLINE »

Source: Pediatric Complaints and Diagnostic Dilemmas, 2003

Poor Weight Gain - Case 6-5: 3-Month-Old Girl: I. Differential Diagnosis
(Pediatric Complaints and Diagnostic Dilemmas)

The differential diagnosis in this case included some form of upper bowel obstruction. There was a marked hypochloremic alkalosis to support this kind of loss, along with the associated history. Severe gastroesophageal reflux, gastric outlet obstruction, pyloric stenosis, or some kind of duodenal anomaly (e.g., duplication) was possible. The upper gastrointestinal radiograph delineated the lesion of pyloric stenosis. The electrolyte disturbance was characteristic of an upper bowel atresia with loss of sodium, chloride, and hydrogen ion.

» READ BOOK EXCERPT ONLINE »

Source: Pediatric Complaints and Diagnostic Dilemmas, 2003

Poor Weight Gain - Case 6-6: 21-Month-Old Boy: I. Differential Diagnosis
(Pediatric Complaints and Diagnostic Dilemmas)

The differential diagnosis of weight loss is very extensive and potentially involves almost every organ system. For this child, who had grown and developed somewhat normally, one would not expect a psychosocial cause unless there had been some recent change in the child 's family constitution or living environment. The loss of weight and linear growth over a short period of time suggest an organic cause. The findings of pallor and abdominal distention also suggest narrowing of the differential diagnosis to a disease-based cause.

» READ BOOK EXCERPT ONLINE »

Source: Pediatric Complaints and Diagnostic Dilemmas, 2003

Poor Weight Gain - Case 6-7: 18-Month-Old Boy: I. Differential Diagnosis
(Pediatric Complaints and Diagnostic Dilemmas)

The severity of this child's condition prompted the consideration of a wide differential diagnosis. The parent 's economic status and educational level at first prompted the medical care team to eliminate psychosocial causes. Yet, the child 's response to supportive care and feeding and the normal laboratory pattern that he demonstrated revealed a nonorganic cause for his life-threatening condition.

» READ BOOK EXCERPT ONLINE »

Source: Pediatric Complaints and Diagnostic Dilemmas, 2003


 » Next page: Risk Factors for Weight Gain

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