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Treatments for Wernicke-Korsakoff syndrome
Treatments for Wernicke-Korsakoff syndrome
The list of treatments mentioned in various sources for Wernicke-Korsakoff syndrome includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.
- Treatments for Wernicke's encephalopathy - see also treatment of Wernicke's encephalopathy:
- Treatments for Korsakoff's psychosis - see also treatment of Korsakoff's psychosis:
- Other treatments for Wernicke's encephalopathy - these may also help relieve Korsakoff's psychosis.
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Book Excerpts: Treatment of Wernicke-Korsakoff syndrome
- Treatment - Alcohol-related disorder
- Treatment - Alzheimer's disease
- Treatment - Alcoholism
- Treatment - Alzheimer's disease
- Patient counseling - Confusion
- Nursing considerations - Confusion
Treatments of Wernicke-Korsakoff syndrome: Online Medical Books
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the treatments of Wernicke-Korsakoff syndrome.
Alcohol-related disorder:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Total abstinence from alcohol is the only effective treatment. Supportive programs that offer detoxification, rehabilitation, and aftercare, including continued involvement in Alcoholics Anonymous (AA), may produce good long-term results.
Acute intoxication is treated symptomatically by supporting respiration, preventing aspiration of vomitus, replacing fluids, administering I.V. glucose to prevent hypoglycemia, correcting hypothermia or acidosis, and initiating emergency treatment for trauma, infection, or GI bleeding.
Treatment of chronic alcohol abuse requires a varied approach that may include medications to deter alcohol use and treat effects of withdrawal; psychotherapy, consisting of behavior modification techniques, group therapy, and family therapy; and appropriate measures to relieve associated physical problems.
Aversion, or deterrent, therapy involves a daily oral dose of disulfiram to prevent compulsive drinking. This drug interferes with alcohol metabolism and allows toxic levels of acetaldehyde to accumulate in the patient’s blood, producing immediate and potentially fatal distress in the event he consumes alcohol up to 2 weeks after taking it. Disulfiram is contraindicated during pregnancy and in the patient with diabetes, heart disease, severe hepatic disease, or any disorder in which such a reaction could be especially dangerous. Another form of aversion therapy attempts to induce aversion by administering alcohol with an emetic.
The first drug approved by the U.S. Food and Drug Administration for the treatment of alcohol-related disorder since disulfiram is naltrexone, an opiate antagonist that effectively reduces the amount of intake, severity of craving, and relapse incidence. It’s believed to work by preventing the effects of increased endorphins produced as a product of increased alcohol intake.
For long-term success, the recovering individual must learn to fill the place alcohol once occupied in his life with something constructive. Therapy using disulfiram or naltrexone may only substitute one drug dependence for another, so it should be used prudently.
Benzodiazepine isn’t recommended during rehabilitation due to its addictive nature and the potential for reinforcing the substance abuse behavior.
Supportive counseling or individual, group, or family psychotherapy may help. Ongoing support groups are helpful. In AA, a self-help group with more than 1 million members worldwide, the alcoholic finds emotional support from others with similar problems. About 40% of AA’s members stay sober as long as 5 years, and 30% stay sober longer than 5 years.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Therapy consists of attempts to slow disease progression, manage behavioral problems, modify the home environment, and elicit family support. Some medications have proven helpful. Tacrine, a centrally acting anticholinesterase agent, is given to treat memory deficits. It has slowed progression of the disease and improved cognitive function in some patients. Other agents include donepezil and rivastigmine. Underlying disorders that contribute to the patient’s confusion, such as hypoxia, are also identified and treated.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Total abstinence from alcohol is the only effective treatment. Supportive programs that offer detoxification, rehabilitation, and aftercare, including continued involvement in Alcoholics Anonymous, may produce good long-term results.
Acute intoxication is treated symptomatically by supporting respiration, preventing aspiration of vomitus, replacing fluids, administering I.V. glucose to prevent hypoglycemia, correcting hypothermia or acidosis, and initiating emergency treatment for trauma, infection, or GI bleeding. Acute withdrawal is also treated with oral multiple B vitamins, including thiamine. Administer fluids as needed, but avoid overhydrating the patient.
CLINICAL TIP: The possibility of intoxication with other drugs should be considered and a blood or urine sample sent for toxicology as appropriate.
Treatment of chronic alcoholism involves counseling, education, and cognitive techniques; psychotherapy (consisting of behavior modification techniques, group therapy, and family therapy); and appropriate measures to relieve associated physical problems. Aversion, or deterrent, therapy may involve a daily oral dose of disulfiram to prevent compulsive drinking. (See Avoiding the risks of disulfiram therapy.) UNDER STUDY: The opioid-antagonist drug naltrexone has been shown to reduce the ability to return to drinking and shorten periods of relapse. Longer-term trials are needed.
Tranquilizers, particularly the benzodiazepines, are used to decrease withdrawal symptoms of the central nervous system and are administered routinely to decrease risk of seizures. These drugs are administered and decreased over 3 to 5 days. Status epilepticus should be treated aggressively; initial treatment with lorazepam I.V. is effective.
Supportive counseling or individual, group, or family psychotherapy may help. Ongoing support groups are also helpful.
Source: Handbook of Diseases, 2003
A cerebral vasodilator (such as ergoloid mesylate or isoxsuprine) is prescribed to enhance the brain’s circulation; hyperbaric oxygen, to increase oxygenation to the brain; a psychostimulator (such as methylphenidate), to enhance the patient’s mood; and an antidepressant, to treat depression, if that seems to exacerbate the patient’s dementia. Donepezil and nivastigmine, which are centrally acting anticholinesterases, are given to treat memory deficits.
Most drug therapies being used are experimental. These include choline salts, lecithin, physostigmine, enkephalins, and naloxone, which may slow the disease process. Antioxidant therapy is also being investigated. Another approach to treatment includes avoiding the use of antacids containing aluminum, aluminum cooking utensils, and aluminum-containing deodorants to help decrease aluminum intake.
Source: Handbook of Diseases, 2003
To help the patient stay oriented, keep a large calendar and a clock visible, and make a list of his activities with specific dates and times. Always reintroduce yourself to the patient each time you enter his room.
Source: Signs & Symptoms: A 2-in-1 Reference for Nurses, 2007
▪ Never leave a confused patient unattended, to prevent injury to himself and others.
▪ Take measures to ensure patient safety.
▪ Keep the patient calm and quiet, and plan uninterrupted rest periods.
▪ Correct the underlying cause of the patient's confusion.
▪ To help the patient stay oriented, keep a large calendar and a clock visible, and make a list of his activities with specific dates and times.
▪ Always reintroduce yourself to the patient each time you enter his room.
▪ If possible, explain to the patient and his family the cause of his confusion.
Source: Nursing: Interpreting Signs and Symptoms, 2007
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Medical Articles:
Alzheimer's disease:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Alcoholism:
Treatment
(Handbook of Diseases)
Alzheimer's disease:
Treatment
(Handbook of Diseases)
Confusion:
Patient counseling
(Signs & Symptoms: A 2-in-1 Reference for Nurses)
Confusion:
Nursing considerations
(Nursing: Interpreting Signs and Symptoms)
Patient teaching
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