Cure Research for West Nile fever

Cure Research discussion for West Nile fever:

NIAID Research on West Nile and Related Viruses, NIAID Fact Sheet: NIAID (Excerpt)

NIAID grantee Dr. Robert Sidwell of Utah State University in Logan is establishing a system to screen chemical compounds for possible activity against West Nile virus. At the University of California, Irvine, Dr. Ian Lipkin heads an NIH-supported project investigating emerging diseases and developing candidate drugs to fight West Nile virus. Promising antiviral drug candidates will be tested in animal models for safety and efficacy before moving on to human trials. (Source: excerpt from NIAID Research on West Nile and Related Viruses, NIAID Fact Sheet: NIAID)

NIAID Research on West Nile and Related Viruses, NIAID Fact Sheet: NIAID (Excerpt)

NIAID recently funded a fast-track project to develop a candidate West Nile virus vaccine. In the first phase of the project, scientists will create the prototype vaccine and conduct initial feasibility studies. If the company successfully meets the Phase 1 goals by April 2001, NIAID will award Phase 2 funding for up to two more years, including plans for initial human clinical trials. Dr. Thomas Monath of OraVax (Cambridge, MA) heads the project.

The design of the West Nile virus vaccine is similar to that of an experimental vaccine made for Japanese encephalitis virus, a closely related flavivirus, that Oravax will begin testing in humans this fall. Essentially, scientists construct a live but weakened virus vaccine using the approved vaccine for yellow fever (caused by another flavivirus) as the backbone. For the Japanese encephalitis vaccine, scientists removed the yellow fever virus coat protein and replaced it with the outer protein of Japanese encephalitis virus. Similarly, for the West Nile vaccine, researchers will substitute the surface protein of West Nile virus for the deleted yellow fever virus protein. This method of creating chimeric flavivirus vaccines – developed by NIAID grantee Dr. Thomas Chambers of Saint Louis University – is also being applied to developing a vaccine for dengue.

In addition, Dr. Chambers' research group carries out basic research that may influence vaccine development strategies. Specifically, they conduct studies in mice to determine which flavivirus proteins contribute to the virus's ability to cause disease. They also investigate how protective immune responses are elicited within the central nervous system during acute flavivirus encephalitis. (Source: excerpt from NIAID Research on West Nile and Related Viruses, NIAID Fact Sheet: NIAID)

West Nile fever Treatment: Book Excerpts

• Treatment - Fever
• Treatment - Rash with Fever
• Treatment - Fever – Cyclic
• Treatment - Fever – Recurrent
• Treatment - Fever – Unknown Origin
• Treatment - Fever – Acute
• Emergency interventions - Fever
• Treatment - West Nile encephalitis
• Treatment - Colorado tick fever
• Treatment - Lassa fever
• Treatment - Relapsing fever
• Treatment - Rheumatic fever and rheumatic heart disease
• Treatment - Rocky Mountain spotted fever
• Emergency interventions - Fever [Pyrexia]
• Treatment - West Nile encephalitis
• Treatment - Rheumatic fever and rheumatic heart disease
• Nursing considerations - Fever
• Emergency Actions - Fever
• Nursing considerations - Fever [Pyrexia]

Clinical Trials for West Nile fever

Some of the clinical trials for West Nile fever include:

• An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - AVI-4020 Injection
• Vaccine to Prevent West Nile Virus Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - VRC-WNVDNA017-00-VP
• Phase I Study of West Nile Virus Vaccine - This study is currently recruiting patients (Current: 23 Nov 2006) - VRC-WNVDNA020-00-VP
• Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults - This study is currently recruiting patients (Current: 23 Nov 2006)
• more trials...»

Evidence Based Medicine Research for West Nile fever

Medical research papers related to West Nile fever include:

• Prognosis after West Nile virus infection.
• West nile fever
• Mosquito
• Virology
• Microbiology
• West Nile Encephalitis (Follow-up)
• West Nile Encephalitis (Treatment)
• Statement on tick-borne encephalitis
• West Nile Virus (Diagnosis)
• West Nile Encephalitis (Diagnosis)
• West Nile Encephalitis (Overview)
• West Nile Virus (Follow-up)
• West Nile Virus (Treatment)
• West Nile Virus (Overview)
• Encephalitis (Follow-up)
• Insect Bites (Overview)
• Encephalitis (Diagnosis)
• Encephalitis (Treatment)
• Insect Bites (Diagnosis)
• Insect Bites (Treatment)
• Influenza (Overview)
• Encephalitis (Overview)
• Insect Bites (Follow-up)
• Management of patients with West Nile Virus : guidelines for health care providers
• Clinical characteristics and functional outcomes of West Nile Fever.
• West Nile virus: pathogenesis and therapeutic options.
• Flu, bird
• West Nile Virus in the United States: An Update on an Emerging Infectious Disease

Click here to find more evidence-based articles on the TRIP Database

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