Inheritance and Genetics of Wilson's Disease
Wilson's Disease Genetics: Book Excerpts
Inheritance of Wilson's Disease:
Autosomal recessive diseases are usually inherited from both parents who are both usually symptom-free genetic carriers (i.e. neither has the disease). See inheritance of autosomal recessive diseases.
Wilson's Disease: Inheritance and Genetics Details
Inheritance properties of Wilson's Disease:
Disease inherited from:
Usually both parents who are symptom-free genetic carriers of Wilson's Disease; see inheritance of autosomal recessive diseases.
Gender bias in inheritance:
Male or females get the disease equally.
Inheritance Patterns
Inheritance odds for Wilson's Disease:
Overall odds of inheritance:
Usually both parents who are symptom-free genetic carriers of Wilson's Disease; see inheritance of autosomal recessive diseases.
Sibling of diseased child odds of inheriting disease:
25% usually for an autosomal recessive disease.
Inheritance from one diseased parent odds:
Usually 0% of disease, 100% of being a genetic carrier if one parent has an autosomal recessive disease (not just carrier).
Inheritance from two diseased parents odds:
100%. Rare case where both parents are not carriers but actually have the autosomal recessive disease.
Genetic Carriers
Genetic carriers of Wilson's Disease:
Inheritance from one carrier parent odds:
0% approximately.
Inheritance from two carrier parents odds:
25% disease, 50% chance carrier, 25% neither for autosomal recessive diseases.
Inheritance Features
Inheritance features for Wilson's Disease:
Inheritance pattern:
Inheritance patterns for autosomal recessive diseases tend to be "horizontal".
Sporadic form of disease possible?:
Very unlikely.
Inheritance and Genetics Information
Inheritance of Wilson's Disease:
Wilson's disease is hereditary.
(Source: excerpt from Wilson's Disease: NIDDK)
Wilson's Disease: Genetics Information
Genetics of Wilson's Disease:
The gene for Wilson's disease (ATP7B) was mapped to chromosome 13. The sequence of the gene was found to be similar to sections of the gene defective in Menkes disease, another disease caused by defects in copper transport. The similar sequences code for copper-binding regions, which are part of a transmembrane pump called a P-type ATPase that is very similar to the Menkes disease protein.
(Source: Genes and Disease by the National Center for Biotechnology)
About inheritance and genetics:
Inheritance of Wilson's Disease refers to whether the condition is inherited
from your parents or "runs" in families.
The level of inheritance of a condition depends
on how important genetics are to the disease.
Strongly genetic diseases are usually inherited,
partially genetic diseases are sometimes inherited,
and non-genetic diseases are not inherited.
For general information, see Introduction to Genetics.
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