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What is the WBC count? Thrombocytopenia with a high white count suggests leukemia or myeloid metaplasia. Thrombocytopenia with a normal white count suggests idiopathic thrombocytopenic purpura or drug reaction. ... DIAGNOSTIC WORKUP
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Thrombocytopenia is defined as a platelet count of <150,000. Mild (100,000–150,000) and moderate (50,000–100,000) thrombocytopenia are rarely associated with significant bleeding. In contrast to the deep muscle and joint bleeds seen with>... Differential Diagnosis ... Workup and Diagnosis ... Treatment
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... The mnemonic VINDICATE is very useful to develop a list of causes of thrombocytopenia.
THROMBOCYTOPENIA
V—Vascular should help the recall of DIC.
I—Inflammation.
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... Decreased Production
Primary hematologic disorders
Aplastic anemia
Acute leukemia
Lymphoproliferative
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... Candidiasis, esophageal, bronchial, tracheal, pulmonary
Extrapulmonary cryptococcosis
Extrapulmonary coccidioidomycosis
Extrapulmonary or disseminated histoplasmosis
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... 1. Hoeprich PD, Jordan CM, Ronald AR: Infectious Diseases: A Treatise of Infectious Processes, 5/e. Philadelphia: JB Lippincott Co, 1994.
2. Kelley WN. Textbook of Internal Medicine, 3/e. Philadelphia: Lippincott–Raven, 1997.
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... Atopic dermatitis is a chronic skin disorder that’s characterized by superficial skin inflammation and intense itching. Although this disorder may appear at any age, it typically begins during infancy or early childhood. It may then subside spontaneously, followed by... Causes ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations
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... The most common cause of hemorrhagic disorders, thrombocytopenia is characterized by deficiency of circulating platelets. Because platelets play a vital role in coagulation, this disease poses a serious threat to hemostasis. (See What happens in... Causes ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations ... Pictures
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... Also called immunodeficiency with eczema and thrombocytopenia, this disease is an X-linked, recessive immunodeficiency disorder characterized by defective B-cell and T-cell functions. Its clinical features include thrombocytopenia with severe bleeding, eczema,... Causes and incidence ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations
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... Acquired immunodeficiency syndrome (AIDS) is a serious secondary immunodeficiency disorder caused by the human immunodeficiency virus (HIV). Both diseases are characterized by the progressive destruction of cell-mediated (T-cell) immunity with... Causes and incidence ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations ... Pictures
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... Common variable immunodeficiency is characterized by progressive deterioration of B-cell (humoral) immunity, resulting in increased susceptibility to infection. Unlike X-linked hypogammaglobulinemia, this disorder (also known as acquired... Causes ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations
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... In severe combined immunodeficiency disease (SCID), both cell-mediated (T-cell) and humoral (B-cell) immunity are deficient or absent, resulting in susceptibility to infection from all classes of microorganisms during infancy. It’s the most severe form of T-cell and B-cell... Causes and incidence ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations
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... Mark D. Darrow
A low platelet count is usually brought to the attention of the practitioner as the result of an automated complete blood count in an asymptomatic patient (1).
I. Approach. In working through the... Pictures
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... The most common cause of hemorrhagic disorders, thrombocytopenia is characterized by deficiency of circulating platelets. Because platelets play a vital role in coagulation, this disease poses a serious threat to hemostasis. ... Causes ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations ... Pictures
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... Also called acquired hypogammaglobulinemia and agammaglobulinemia with immunoglobulin-bearing B cells, common variable immunodeficiency is characterized by progressive deterioration of B-cell (humoral) immunity. This results in increased susceptibility to infection... Causes ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations
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... One of the most widely publicized diseases, human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) is caused by the marked progressive failure of the immune system. Although it’s characterized by gradual destruction... Causes ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations
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... Both cell-mediated (T-cell) and humoral (B-cell) immunity are deficient or absent in severe combined immunodeficiency disease (SCID). This results in susceptibility to infection from all classes of microorganisms during infancy.
At least three types of SCID... Causes ... Signs and symptoms ... Diagnosis ... Treatment ... Special considerations
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The mnemonic VINDICATE is very useful to develop a list of
causes of thrombocytopenia.
V—Vascular disorders should help
the recall of disseminated intravascular coagulation (DIC).
I—Inflammation. Infectious diseases... Pictures
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... Elena Elizabeth Perez, MD, PhD
Wiskott Aldrich Syndrome - BASICS
Wiskott Aldrich Syndrome - description
An X-linked primary immunodeficiency characterized by the classic clinical triad of thrombocytopenia ... Wiskott Aldrich Syndrome - DIAGNOSIS ... Wiskott Aldrich Syndrome - TREATMENT ... Wiskott Aldrich Syndrome - FOLLOW UP ... Wiskott Aldrich Syndrome - bibliography ... Wiskott Aldrich Syndrome - CODES ... Wiskott Aldrich Syndrome - FAQ
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