Thrombocytopenia
Thrombocytopenia: Excerpt from A Pocket Manual of Differential Diagnosis
Decreased Production
Primary hematologic disorders
Aplastic anemia
Acute leukemia
Lymphoproliferative disorders
Lymphoma
Myeloma
Chronic lymphocytic leukemia
Myeloproliferative disorders
Agnogenic myeloid metaplasia with myelofibrosis
Chronic myelogenous leukemia (accelerated phase)
Myelodysplastic syndromes
Selective megakaryocytic aplasia
Bone marrow infiltration
Solid tumor
Infection
Tuberculosis
Other
Gaucher's disease
Osteopetrosis
Drugs
Selective megakaryocytic suppression
Thiazides
Alcohol
Estrogens
Interferon
Nonselective myelosuppression
Predictable (e.g., antineoplastic chemotherapy)
Idiosyncratic (e.g., phenylbutazone)
Cyclic thrombocytopenia
Nutritional deficiency
Folate
Vitamin B
12
Iron (rare)
Viral infections
Influenza
Rubella
Infectious mononucleosis
Thai hemorrhagic fever
Dengue fever
Others
Paroxysmal nocturnal hemoglobinuria
Hereditary disorders
Wiskott-Aldrich syndrome
May-Hegglin anomaly
Congenital causes
Fanconi's anemia
Amegakaryocytic thrombocytopenia with congenital malformations
Congenital rubella or CMV infection
Maternal thiazide ingestion
Increased Destruction
Congenital: nonimmune
Erythroblastosis fetalis
Maternal preeclampsia
Congenital viral infection
Giant cavernous hemangioma
Congenital: immune
Maternal drug ingestion
Isoimmune neonatal thrombocytopenia
Maternal autoimmune thrombocytopenic purpura
Acquired: nonimmune
Infections
Bacterial
Sepsis
Typhoid fever
Viral
Infectious mononucleosis
CMV
Herpes
Malaria
Rickettsial
Rocky Mountain spotted fever
Toxic shock syndrome
Microangiopathic hemolytic anemia
Disseminated intravascular coagulation
TTP
Hemolytic-uremic syndrome
Vasculitis
Drugs
Extracorporeal circulation
Anaphylaxis
Acquired: immune
Drug-induced
Quinine/quinidine
Gold salts
Heparin
Thiazides
Sulfonamides
Indomethacin
Others
Neoplasia-associated
Lymphoproliferative disorders
Solid tumors
Collagen-vascular disorders
Systemic lupus erythematosus
Rheumatoid arthritis
AIDS or HIV infection
Posttransfusion purpura
Idiopathic autoimmune thrombocytopenic purpura
Acute
Chronic
Sarcoidosis
Hashimoto's thyroiditis
Hyperthyroidism
Sequestration/Dilution
Hypersplenism
Hypothermia
Extracorporeal circulation
Massive blood transfusion
References
1. George J: Thrombocytopenia Due to Diminished or Defective Platelet Production, p. 1281. See Bibliography, 2.
2. George J, El-Harake M: Thrombocytopenia Due to Enhanced Platelet Destruction by Non-Immunologic and Immunologic Mechanisms, p. 1290. See Bibliography, 2.
3. George J: Thrombocytopenia: Pseudothrombocytopenia Hypersplenism, and Thrombocytopenia Associated with Massive Transfusion, pp. 1355. See Bibliography, 2.
4. Aboulafia DM, Mitsuyasu RT: Hematologic Abnormalities in AIDS.
Hematol Oncol Clin N Am 5:195, 1991.
Book Source Details
- Book Title: A Pocket Manual of Differential Diagnosis
- Author(s): Stephen N. Adler, Dianne B. Gasbarra
- Year of Publication: 1999
- Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.
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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.
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Infections and Complications of Human Immunodeficiency Virus Infection in the 1993 Acquired Immunodeficiency Syndrome Surveillance Definition: Adults and Adolescents* (A Pocket Manual of Differential Diagnosis)
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