Inheritance and Genetics of Wiskott-Aldrich Syndrome

Wiskott-Aldrich Syndrome Genetics: Book Excerpts

• Wiskott Aldrich Syndrome - genetics - Wiskott Aldrich Syndrome

Inheritance of Wiskott-Aldrich Syndrome:

X-linked recessive diseases are usually inherited by males from their mother. Rare cases of sporadic genetic disease can also occur. See inheritance of x-linked recessive diseases.

Wiskott-Aldrich Syndrome: Inheritance and Genetics Details

Inheritance properties of Wiskott-Aldrich Syndrome:   Disease inherited from: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.

  Gender bias in inheritance: Males only get x-linked recessive diseases; females are carriers.

Inheritance Patterns

Inheritance odds for Wiskott-Aldrich Syndrome:   Overall odds of inheritance: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.

  Sibling of diseased child odds of inheriting disease: About 50% for a second child if one (male) child already has the x-linked recessive disease.

  Mother to son inheritance odds: 50% disease, 50% disease-free, males cannot be a carrier of an x-linked recessive disease.

  Father to son inheritance odds: 0% chance usually for x-linked recessive diseases.

  Mother to daughter inheritance odds: 0% disease; 50% female carrier, 50% chance neither affected nor carrier.

  Father to daughter inheritance odds: 0% chance of x-linked recessive disease; 100% chance the female child is a carrier.

Inheritance Features

Inheritance features for Wiskott-Aldrich Syndrome:   Sporadic form of disease possible?: Yes, requires single mutation for x-linked recessive disease.

  Milder form of disease possible in females?: Yes, females have mild disease for some x-linked recessive diseases.

About inheritance and genetics:

Inheritance of Wiskott-Aldrich Syndrome refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

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