Symptoms of Wiskott-Aldrich Syndrome
Symptoms of Wiskott-Aldrich Syndrome
The list of signs and symptoms mentioned in various sources
for Wiskott-Aldrich Syndrome includes the 40
symptoms listed below:
Research symptoms & diagnosis of Wiskott-Aldrich Syndrome:
Wiskott-Aldrich Syndrome: Complications
Review medical complications possibly associated with Wiskott-Aldrich Syndrome:
Wiskott-Aldrich Syndrome Symptoms: Book Excerpts
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More information about symptoms of Wiskott-Aldrich Syndrome and related conditions:
Other Possible Causes of these Symptoms
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of other causes including diseases, medical conditions, toxins, drug interactions,
or drug side effect causes of that symptom.
Medical Books Online about Wiskott-Aldrich Syndrome
Medical Books Excerpts
Excerpts of published medical book chapters related to Wiskott-Aldrich Syndrome
are available from published medical books
for more detailed information about Wiskott-Aldrich Syndrome.
Medical Books Excerpts
- Thrombocytopenia
- "The 10-Minute Diagnosis Manual: Symptoms and Signs in the Time-Limited Encounter" (2000)
- [ read ]
Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.
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Patient Surveys for Wiskott-Aldrich Syndrome
Symptoms of Wiskott-Aldrich Syndrome: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the symptoms of Wiskott-Aldrich Syndrome.
Atopic dermatitis:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
Scratching the skin causes vasoconstriction and intensifies pruritus, resulting in erythematous, weeping lesions. Eventually, the lesions become scaly and lichenified. Usually, they’re located in areas of flexion and extension, such as the neck, antecubital fossa, popliteal folds, and behind the ears. Patients with atopic dermatitis are prone to unusually severe viral infections, bacterial and fungal skin infections, ocular complications, and allergic contact dermatitis.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Thrombocytopenia:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
Thrombocytopenia typically produces a sudden onset of petechiae or ecchymoses in the skin or bleeding into any mucous membrane. Nearly all patients are otherwise asymptomatic, although some may complain of malaise, fatigue, and general weakness. In adults, large, blood-filled bullae characteristically appear in the mouth. In severe thrombocytopenia, hemorrhage may lead to tachycardia, shortness of breath, loss of consciousness, and death.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Wiskott-Aldrich syndrome:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
Characteristically, neonates with Wiskott-Aldrich syndrome develop bloody stools, bleeding from a circumcision site, petechiae, and purpura as a result of thrombocytopenia. As the infants get older, thrombocytopenia subsides. However, beginning at about 6 months, they typically develop recurrent systemic infections, such as chronic pneumonia, sinusitis, otitis media, and herpes simplex of the skin and eyes (which may cause keratitis and vision loss), with hepatosplenomegaly. Usually, Streptococcus pneumoniae, meningococci, and Haemophilus influenzae are the infecting organisms. Varicella infection can be lethal. At about age 1, eczema develops and becomes progressively more severe; pruritus and persistent scratching commonly lead to skin infections. These children are also highly vulnerable to certain cancers, especially leukemia and lymphoma.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Acquired immunodeficiency syndrome:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
A person with HIV may remain asymptomatic for months or years. Initially, laboratory evidence or seroconversion to HIV antibodies may be the only clinical evidence of infection. However, as the disease progresses, the patient may develop generalized adenopathy and nonspecific signs and symptoms, such as weight loss, fatigue, night sweats, and fevers. As the patient’s T-cell count lowers further, neurologic symptoms, opportunistic infections, and certain normally rare cancers may develop. HIV also destroys lymph nodes and immunologic organs, leading to major dysfunctions of the immunological system. Eventually, HIV advances to AIDS. (Some individuals, termed nonprogressors, develop AIDS very slowly or not at all. They seem to have genetic differences that prevent the virus from attaching to certain immune receptors.)
PEDIATRIC TIP The clinical course varies slightly in children, who have a shorter incubation time (mean, 17 months.) Signs and symptoms resemble those in adults, except for findings related to sexually transmitted disease (STD). Children show virtually all of the opportunistic infections observed in adults, with a higher incidence of bacterial infections: otitis media, pneumonias other than that caused by Pneumocystis carinii, sepsis, chronic salivary gland enlargement, and lymphoid interstitial pneumonia.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Common variable immunodeficiency:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
In common variable immunodeficiency, pyogenic bacterial infections are characteristic but tend to be chronic rather than acute (as in X-linked hypogammaglobulinemia). Recurrent sinopulmonary infections, chronic bacterial conjunctivitis, and malabsorption (commonly associated with infestation by Giardia lamblia) are usually the first clues to immunodeficiency.
Common variable immunodeficiency may be associated with autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, hemolytic anemia, and pernicious anemia, and with cancers, such as leukemia and lymphoma.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Severe combined immunodeficiency disease:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
An extreme susceptibility to infection becomes obvious in the infant with SCID in the first months of life. The infant fails to thrive and develops chronic otitis; sepsis; watery diarrhea (associated with Salmonella or Escherichia coli); recurrent pulmonary infections (usually caused by Pseudomonas, cytomegalovirus, or Pneumocystis carinii); persistent oral candidiasis, sometimes with esophageal erosions; and possibly fatal viral infections such as chickenpox.
P. carinii pneumonia usually strikes a severely immunodeficient infant in the first 3 to 5 weeks of life. Onset is typically insidious, with gradually worsening cough, low-grade fever, tachypnea, and respiratory distress. Chest X-ray characteristically shows bilateral pulmonary infiltrates.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Thrombocytopenia:
Signs and symptoms
(Handbook of Diseases)
Thrombocytopenia typically produces a sudden onset of petechiae or ecchymoses in the skin or bleeding into any mucous membrane. Nearly all patients are otherwise asymptomatic, although some may complain of malaise, fatigue, and general weakness.
In adults, the brain and the gastrointestinal tract are the most common sites of hemorrhage while large blood-filled bullae characteristically appear in the mouth. The bullae are another site of hemorrhage, but they may not herald GI or brain hemorrhage. In severe thrombocytopenia, hemorrhage may lead to tachycardia, shortness of breath, loss of consciousness, and death.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Common variable immunodeficiency:
Signs and symptoms
(Handbook of Diseases)
With common variable immunodeficiency, pyogenic bacterial infections are characteristic but tend to be chronic rather than acute (as in X-linked hypogammaglobulinemia). Recurrent sinopulmonary infections, chronic bacterial conjunctivitis, and malabsorption (commonly associated with infestation by Giardia lamblia) are usually the first clues to immunodeficiency.
Common variable immunodeficiency may be associated with autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, hemolytic anemia, and pernicious anemia) as well as with cancers (such as leukemia and lymphoma).
Clinical tip Patients with common variable immunodeficiency can develop a nonseptic inflammatory arthritis similar to rheumatoid arthritis. However, because septic arthritis has also been reported, a search for an infecting organism should be undertaken in patients with new joint pain and inflammation, particularly if only one or two joints are affected.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Human immunodeficiency virus infection:
Signs and symptoms
(Handbook of Diseases)
HIV infection manifests itself in many ways.
Clinical tip After a high-risk exposure and inoculation, the infected person usually experiences a mononucleosis-like syndrome, which may be attributed to the flu or another virus, and then may remain asymptomatic for years. In this latent stage, the only sign of HIV infection is laboratory evidence of seroconversion.
When symptoms appear, they may take many forms:
❑ persistent generalized adenopathy
❑ nonspecific symptoms (weight loss, fatigue, night sweats, fevers)
❑ neurologic symptoms resulting from HIV encephalopathy
❑ opportunistic infection or cancer.
The clinical course varies slightly in children with AIDS. Apparently, their incubation time is shorter, with a mean of 17 months. Signs and symptoms resemble those in adults, except for findings related to STDs. Children show virtually all of the opportunistic infections observed in adults, with a higher incidence of bacterial infections, such as otitis media, sepsis, chronic salivary gland enlargement, Mycobacterium avium complex function, and pneumonias, including Pneumocystis carinii and lymphoid interstitial pneumonias.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Severe combined immunodeficiency disease:
Signs and symptoms
(Handbook of Diseases)
An extreme susceptibility to infection becomes obvious in the infant with SCID in the first months of life. The infant fails to thrive and develops chronic otitis, sepsis, watery diarrhea (associated with Salmonella or Escherichia coli), recurrent pulmonary infections (usually caused by Pseudomonas, cytomegalo-virus, or Pneumocystis carinii), persistent oral candidiasis (sometimes with esophageal erosions), and possibly fatal viral infections (such as chickenpox).
P. carinii pneumonia usually strikes a severely immunodeficient infant in the first 3 to 5 weeks of life. Onset is typically insidious, with gradually worsening cough, low-grade fever, tachypnea, and respiratory distress. A chest X-ray characteristically shows bilateral pulmonary infiltrates.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Wiskott-Aldrich Syndrome as a Cause of Symptoms or Medical Conditions
When considering symptoms of Wiskott-Aldrich Syndrome, it is also important to consider Wiskott-Aldrich Syndrome as a possible cause of other medical conditions.
The Disease Database lists the following medical conditions that Wiskott-Aldrich Syndrome may cause:
- (Source - Diseases Database)
Wiskott-Aldrich Syndrome: Onset and Incubation
Onset of Wiskott-Aldrich Syndrome: infancy and childhood
Medical articles and books on symptoms:
These general reference articles may be of interest
in relation to medical signs and symptoms of disease in general:
Full list of premium articles on symptoms and diagnosis
About signs and symptoms of Wiskott-Aldrich Syndrome:
The symptom information on this page
attempts to provide a list of some possible signs and symptoms of Wiskott-Aldrich Syndrome.
This signs and symptoms information for Wiskott-Aldrich Syndrome has been gathered from various sources,
may not be fully accurate,
and may not be the full list of Wiskott-Aldrich Syndrome signs or Wiskott-Aldrich Syndrome symptoms.
Furthermore, signs and symptoms of Wiskott-Aldrich Syndrome may vary on an individual basis for each patient.
Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they
are indeed Wiskott-Aldrich Syndrome symptoms.
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» Next page:
Diagnostic Tests for Wiskott-Aldrich Syndrome
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