Symptoms of Wiskott-Aldrich Syndrome

List of symptoms of Wiskott-Aldrich Syndrome:

The list of signs and symptoms mentioned in various sources for Wiskott-Aldrich Syndrome includes the 40 symptoms listed below:

• Severe recurrent infections
• Bleeding easily
• Defective blood platelets
• Scaling skin rash (eczema)
• Itching
• Opportunistic infections
• Candida
• Pneumocystis
• Herpes viruses
• Pruritus
• Skin erythema
• Skin papules
• Dry skin
• Earache
• Fever
• Balance difficulties
• Sleeping difficulties
• Fatigue
• Tachypnea
• Dyspnea
• Chest pain
• Syncope
• Pallor
• Neuropathy
• Eczema
• Easy bruising
• Hemorrhage
• Recurrent infections
• Recurrent middle ear inflammation
• Bloody diarrhea
• Hemorrhagic skin spots
• Hematomas
• Periosteal hemorrhages
• Anemia
• Lymphopenia
• Decreased gamma globulin levels in blood
• Reduced platelet production
• Small platelets
• Thrombi of lymph node vessels
• Low blood platelet level

Note that Wiskott-Aldrich Syndrome symptoms usually refers to various symptoms known to a patient, but the phrase Wiskott-Aldrich Syndrome signs may refer to those signs only noticable by a doctor.

More ways to research these symptoms: To research other symptoms use the symptom center, or to research causes of more than one symptom in combination, try our multi-symptom search.

Research More About Wiskott-Aldrich Syndrome

Do I have Wiskott-Aldrich Syndrome?

• Wiskott-Aldrich Syndrome: Introduction
• Wiskott-Aldrich Syndrome: Diagnostic Testing to confirm diagnosis
• How serious is it?
• Treatments for Wiskott-Aldrich Syndrome
• More about Wiskott-Aldrich Syndrome

More about symptoms of Wiskott-Aldrich Syndrome:

More information about symptoms of Wiskott-Aldrich Syndrome and related conditions:

• Tests to determine if these are the symptoms of Wiskott-Aldrich Syndrome
• Symptoms that may be caused by complications of Wiskott-Aldrich Syndrome

Other Possible Causes of these Symptoms

Click on any of the symptoms below to see a full list of other causes including diseases, medical conditions, toxins, drug interactions, or drug side effect causes of that symptom.

• Anemia - see all causes of Anemia
• Balance difficulties - see all causes of Balance symptoms
• Bleeding easily - see all causes of Bleeding symptoms
• Bloody diarrhea - see all causes of Bloody diarrhea
• Candida - see all causes of Candida
• Chest pain - see all causes of Chest pain
• Defective blood platelets - see all causes of Clotting symptoms
• Dry skin - see all causes of Dry skin
• Dyspnea - see all causes of Breathing difficulties
• Earache - see all causes of Earache
• Easy bruising - see all causes of Easy bruising
• Eczema - see all causes of Eczema
• Fatigue - see all causes of Fatigue
• Fever - see all causes of Fever
• Hematomas - see all causes of Hematomas
• Hemorrhage - see all causes of Bleeding symptoms
• Hemorrhagic skin spots - see all causes of Bleeding under skin
• Itching - see all causes of Itching skin
• Low blood platelet level - see all causes of Low blood platelet level
• Neuropathy - see all causes of Neuropathy
• Opportunistic infections - see all causes of Infection
• Pallor - see all causes of Paleness
• Pneumocystis - see all causes of Pneumocystis
• Pruritus - see all causes of Pruritus
• Recurrent infections - see all causes of Recurrent infections
• Scaling skin rash (eczema) - see all causes of Scaly skin
• Severe recurrent infections - see all causes of Infection
• Sleeping difficulties - see all causes of Insomnia
• Syncope - see all causes of Syncope
• Tachypnea - see all causes of Rapid breathing

Medical Books Online about Wiskott-Aldrich Syndrome

Medical Books Excerpts Excerpts of published medical book chapters related to Wiskott-Aldrich Syndrome are available from published medical books for more detailed information about Wiskott-Aldrich Syndrome.

Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

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Symptoms of Wiskott-Aldrich Syndrome: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the symptoms of Wiskott-Aldrich Syndrome.

Atopic dermatitis: Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))

Scratching the skin causes vasoconstriction and intensifies pruritus, resulting in erythematous, weeping lesions. Eventually, the lesions become scaly and lichenified. Usually, they’re located in areas of flexion and extension, such as the neck, antecubital fossa, popliteal folds, and behind the ears. Patients with atopic dermatitis are prone to unusually severe viral infections, bacterial and fungal skin infections, ocular complications, and allergic contact dermatitis.

READ BOOK EXCERPT ONLINE »

Thrombocytopenia: Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))

Thrombocytopenia typically produces a sudden onset of petechiae or ecchymoses in the skin or bleeding into any mucous membrane. Nearly all patients are otherwise asymptomatic, although some may complain of malaise, fatigue, and general weakness. In adults, large, blood-filled bullae characteristically appear in the mouth. In severe thrombocytopenia, hemorrhage may lead to tachycardia, shortness of breath, loss of consciousness, and death.

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Wiskott-Aldrich syndrome: Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))

Characteristically, neonates with Wiskott-Aldrich syndrome develop bloody stools, bleeding from a circumcision site, petechiae, and purpura as a result of thrombocytopenia. As the infants get older, thrombocytopenia subsides. However, beginning at about 6 months, they typically develop recurrent systemic infections, such as chronic pneumonia, sinusitis, otitis media, and herpes simplex of the skin and eyes (which may cause keratitis and vision loss), with hepatosplenomegaly. Usually, Streptococcus pneumoniae, meningococci, and Haemophilus influenzae are the infecting organisms. Varicella infection can be lethal. At about age 1, eczema develops and becomes progressively more severe; pruritus and persistent scratching commonly lead to skin infections. These children are also highly vulnerable to certain cancers, especially leukemia and lymphoma.

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Acquired immunodeficiency syndrome: Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))

A person with HIV may remain asymptomatic for months or years. Initially, laboratory evidence or seroconversion to HIV antibodies may be the only clinical evidence of infection. However, as the disease progresses, the patient may develop generalized adenopathy and nonspecific signs and symptoms, such as weight loss, fatigue, night sweats, and fevers. As the patient’s T-cell count lowers further, neurologic symptoms, opportunistic infections, and certain normally rare cancers may develop. HIV also destroys lymph nodes and immunologic organs, leading to major dysfunctions of the immunological system. Eventually, HIV advances to AIDS. (Some individuals, termed nonprogressors, develop AIDS very slowly or not at all. They seem to have genetic differences that prevent the virus from attaching to certain immune receptors.)

PEDIATRIC TIP The clinical course varies slightly in children, who have a shorter incubation time (mean, 17 months.) Signs and symptoms resemble those in adults, except for findings related to sexually transmitted disease (STD). Children show virtually all of the opportunistic infections observed in adults, with a higher incidence of bacterial infections: otitis media, pneumonias other than that caused by Pneumocystis carinii, sepsis, chronic salivary gland enlargement, and lymphoid interstitial pneumonia.

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Common variable immunodeficiency: Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))

In common variable immunodeficiency, pyogenic bacterial infections are characteristic but tend to be chronic rather than acute (as in X-linked hypogammaglobulinemia). Recurrent sinopulmonary infections, chronic bacterial conjunctivitis, and malabsorption (commonly associated with infestation by Giardia lamblia) are usually the first clues to immunodeficiency.

Common variable immunodeficiency may be associated with autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, hemolytic anemia, and pernicious anemia, and with cancers, such as leukemia and lymphoma.

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Severe combined immunodeficiency disease: Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))

An extreme susceptibility to infection becomes obvious in the infant with SCID in the first months of life. The infant fails to thrive and develops chronic otitis; sepsis; watery diarrhea (associated with Salmonella or Escherichia coli); recurrent pulmonary infections (usually caused by Pseudomonas, cytomegalovirus, or Pneumocystis carinii); persistent oral candidiasis, sometimes with esophageal erosions; and possibly fatal viral infections such as chickenpox.

P. carinii pneumonia usually strikes a severely immunodeficient infant in the first 3 to 5 weeks of life. Onset is typically insidious, with gradually worsening cough, low-grade fever, tachypnea, and respiratory distress. Chest X-ray characteristically shows bilateral pulmonary infiltrates.

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Thrombocytopenia: Signs and symptoms
(Handbook of Diseases)

Thrombocytopenia typically produces a sudden onset of petechiae or ecchymoses in the skin or bleeding into any mucous membrane. Nearly all patients are otherwise asymptomatic, although some may complain of malaise, fatigue, and general weakness.

In adults, the brain and the gastrointestinal tract are the most common sites of hemorrhage while large blood-filled bullae characteristically appear in the mouth. The bullae are another site of hemorrhage, but they may not herald GI or brain hemorrhage. In severe thrombocytopenia, hemorrhage may lead to tachycardia, shortness of breath, loss of consciousness, and death.

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Common variable immunodeficiency: Signs and symptoms
(Handbook of Diseases)

With common variable immunodeficiency, pyogenic bacterial infections are characteristic but tend to be chronic rather than acute (as in X-linked hypogammaglobulinemia). Recurrent sinopulmonary infections, chronic bacterial conjunctivitis, and malabsorption (commonly associated with infestation by Giardia lamblia) are usually the first clues to immunodeficiency.

Common variable immunodeficiency may be associated with autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, hemolytic anemia, and pernicious anemia) as well as with cancers (such as leukemia and lymphoma).

Clinical tip  Patients with common variable immunodeficiency can develop a nonseptic inflammatory arthritis similar to rheumatoid arthritis. However, because septic arthritis has also been reported, a search for an infecting organism should be undertaken in patients with new joint pain and inflammation, particularly if only one or two joints are affected.

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Human immunodeficiency virus infection: Signs and symptoms
(Handbook of Diseases)

HIV infection manifests itself in many ways.

Clinical tip  After a high-risk exposure and inoculation, the infected person usually experiences a mononucleosis-like syndrome, which may be attributed to the flu or another virus, and then may remain asymptomatic for years. In this latent stage, the only sign of HIV infection is laboratory evidence of seroconversion.

When symptoms appear, they may take many forms:

❑ persistent generalized adenopathy

❑ nonspecific symptoms (weight loss, fatigue, night sweats, fevers)

❑ neurologic symptoms resulting from HIV encephalopathy

❑ opportunistic infection or cancer.

The clinical course varies slightly in children with AIDS. Apparently, their incubation time is shorter, with a mean of 17 months. Signs and symptoms resemble those in adults, except for findings related to STDs. Children show virtually all of the opportunistic infections observed in adults, with a higher incidence of bacterial infections, such as otitis media, sepsis, chronic salivary gland enlargement, Mycobacterium avium complex function, and pneumonias, including Pneumocystis carinii and lymphoid interstitial pneumonias.

READ BOOK EXCERPT ONLINE »

Severe combined immunodeficiency disease: Signs and symptoms
(Handbook of Diseases)

An extreme susceptibility to infection becomes obvious in the infant with SCID in the first months of life. The infant fails to thrive and develops chronic otitis, sepsis, watery diarrhea (associated with Salmonella or Escherichia coli), recurrent pulmonary infections (usually caused by Pseudomonas, cytomegalo-virus, or Pneumocystis carinii), persistent oral candidiasis (sometimes with esophageal erosions), and possibly fatal viral infections (such as chickenpox).

P. carinii pneumonia usually strikes a severely immunodeficient infant in the first 3 to 5 weeks of life. Onset is typically insidious, with gradually worsening cough, low-grade fever, tachypnea, and respiratory distress. A chest X-ray characteristically shows bilateral pulmonary infiltrates.

READ BOOK EXCERPT ONLINE »

Wiskott-Aldrich Syndrome as a Cause of Symptoms or Medical Conditions

When considering symptoms of Wiskott-Aldrich Syndrome, it is also important to consider Wiskott-Aldrich Syndrome as a possible cause of other medical conditions. The Disease Database lists the following medical conditions that Wiskott-Aldrich Syndrome may cause:

• Eosinophilia
• Gastrointestinal bleeding
• Glomerulonephritis
• Hypogammaglobulinaemia
• Immune deficiency
• Lymphocytopenia
• Mean platelet volume decreased
• Platelet dysfunction / hypofunction
• Rash
• Thrombocytopenia

Medical articles and books on symptoms:

These general reference articles may be of interest in relation to medical signs and symptoms of disease in general:

• Diagnostic Testing for a Diagnosis of Wiskott-Aldrich Syndrome
• How serious is Wiskott-Aldrich Syndrome?
• More about Wiskott-Aldrich Syndrome
• Online Diagnosis
• Self Diagnosis Pitfalls
• Pitfalls of Online Diagnosis
• Symptoms of the Silent Killer Diseases
• Lesser known silent killer diseases
• Books on signs and symptoms

Full list of premium articles on symptoms and diagnosis

About signs and symptoms of Wiskott-Aldrich Syndrome:

The symptom information on this page attempts to provide a list of some possible signs and symptoms of Wiskott-Aldrich Syndrome. This signs and symptoms information for Wiskott-Aldrich Syndrome has been gathered from various sources, may not be fully accurate, and may not be the full list of Wiskott-Aldrich Syndrome signs or Wiskott-Aldrich Syndrome symptoms. Furthermore, signs and symptoms of Wiskott-Aldrich Syndrome may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Wiskott-Aldrich Syndrome symptoms.