What is X-Linked Agammaglobulinemia?

What is X-Linked Agammaglobulinemia?

• X-Linked Agammaglobulinemia: Immune deficiency from lack of antibodies.

X-Linked Agammaglobulinemia is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that X-Linked Agammaglobulinemia, or a subtype of X-Linked Agammaglobulinemia, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

X-Linked Agammaglobulinemia: Introduction

Types of X-Linked Agammaglobulinemia:

Broader types of X-Linked Agammaglobulinemia:

• Primary Immune Deficiency
• Immune disorders
• Immune deficiency conditions
• Genetic Disease
• Recessive Genetic Diseases
• X-linked Genetic Diseases
• X-linked Recessive Genetic Diseases
• Carrier conditions
• X Chromosome Disorders
• more types...»

How many people get X-Linked Agammaglobulinemia?

Prevalance of X-Linked Agammaglobulinemia: 1-in-100,000
Prevalance Rate of X-Linked Agammaglobulinemia: approx 1 in 100,000 or 0.00% or 2,720 people in USA [about data]
Prevalance of X-Linked Agammaglobulinemia: One out of 100,000 people have XLA. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)

Who gets X-Linked Agammaglobulinemia?

Patient Profile for X-Linked Agammaglobulinemia: Infants. Symptoms develop early.

Gender Profile for X-Linked Agammaglobulinemia: Boys only (X-linked recessive).

Gender Profile for X-Linked Agammaglobulinemia: Only boys get XLA. That is because girls have two sets of X chromosomes, and the normal copy compensates for the faulty gene. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)

How serious is X-Linked Agammaglobulinemia?

Complications of X-Linked Agammaglobulinemia: see complications of X-Linked Agammaglobulinemia

What causes X-Linked Agammaglobulinemia?

Causes of X-Linked Agammaglobulinemia: see causes of X-Linked Agammaglobulinemia
Cause of X-Linked Agammaglobulinemia: Genetic defect in the gene producing a protein called btk for B-cell development.
Causes of X-Linked Agammaglobulinemia: Alternations in a gene found on the X chromosome cause XLA. This gene normally produces a protein called btk, which is required for B-cell development. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)

What are the symptoms of X-Linked Agammaglobulinemia?

Symptoms of X-Linked Agammaglobulinemia: see symptoms of X-Linked Agammaglobulinemia

Complications of X-Linked Agammaglobulinemia: see complications of X-Linked Agammaglobulinemia

Can anyone else get X-Linked Agammaglobulinemia?

Inheritance: see inheritance of X-Linked Agammaglobulinemia

Inheritance of genetic conditions: see details in inheritance of genetic diseases.

X-Linked Agammaglobulinemia: Testing

Diagnostic testing: see tests for X-Linked Agammaglobulinemia.

Misdiagnosis: see misdiagnosis and X-Linked Agammaglobulinemia.

How is it treated?

Treatments for X-Linked Agammaglobulinemia: see treatments for X-Linked Agammaglobulinemia
Research for X-Linked Agammaglobulinemia: see research for X-Linked Agammaglobulinemia

Organs Affected by X-Linked Agammaglobulinemia:

Organs and body systems related to X-Linked Agammaglobulinemia include:

• Immune system
• White blood cells
• X chromosome

Name and Aliases of X-Linked Agammaglobulinemia

Main name of condition: X-Linked Agammaglobulinemia

Class of Condition for X-Linked Agammaglobulinemia: genetic x-linked recessive

XLA, Bruton type agammaglobulinemia, X-linked infantile agammaglobulinemia, congenital agammaglobulinemia, Agammaglobulinemia, Bruton tyrosine kinase, Agammaglobulinemia, BTK, B cell progenitor kinase, Bruton-type (congenital X-linked) agammaglobulinemia

Agammaglobulinemia, BTK, Agammaglobulinemia, Bruton tyrosine kinase, B cell progenitor kinase, Bruton-type (congenital X-linked) agammaglobulinemia
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Research the causes of these diseases that are similar to, or related to, X-Linked Agammaglobulinemia:

• Transient hypogammaglobulinemia of infancy
• B-cell disorders
• Spondyloepiphyseal dysplasia
• Retinal dystrophy
• Growth hormone deficiency
• Pneumonia
• Bacteremia
• Sinusitis
• Bronchiectasis
• Streptococcus pneumoniae
• Haemophilus influenzae

 » Next page: Online Medical Textbooks for X-Linked Agammaglobulinemia

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