1-in-100,000 ... see also overview of X-Linked Agammaglobulinemia.
approx 1 in 100,000 or 0.00% or 2,720 people in USA [Source statistic for calcuation: "1-in-100,000" -- see also general information about data sources]
X-Linked Agammaglobulinemia is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that X-Linked Agammaglobulinemia, or a subtype of X-Linked Agammaglobulinemia, affects less than 200,000 people in the US population.
One out of 100,000 people have XLA. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the prevalence and/or incidence of X-Linked Agammaglobulinemia.
In this disease, B cells and B-cell precursors may be present in the bone marrow and peripheral blood, but a mutation in the B-cell protein tyrosine kinase causes failure of the B cells to mature and to secrete immunoglobulin. In the absence of protective immunoglobulins, the affected individual develops repeated infections. Worldwide, malnutrition is the primary cause of antibody disorders.
Humoral immune deficiencies account for 50% of all primary immunodeficiencies. IgA deficiency is the most common antibody deficiency symdrome, followed by common variable immunodeficiency (CVID). The incidence of these two disorders is 1 in 700 persons.Selective IgM deficiency is rare. IgG4 deficiency occurs in 10% to 15% of the population.
Source: Professional Guide to Diseases (Eighth Edition), 2005
The term 'prevalence' of X-Linked Agammaglobulinemia usually refers to the estimated population of people who are managing X-Linked Agammaglobulinemia at any given time. The term 'incidence' of X-Linked Agammaglobulinemia refers to the annual diagnosis rate, or the number of new cases of X-Linked Agammaglobulinemia diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.
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