Zellweger Syndrome

Introduction: Zellweger Syndrome

Zellweger Syndrome: Zellweger syndrome is a rare hereditary disorder affecting infants, and usually results in death. (Source: Genes and Disease by the National Center for Biotechnology) ... more about Zellweger Syndrome.

Zellweger Syndrome: A leukodystrophy that is caused by a absence of peroxisomes. More detailed information about the symptoms, causes, and treatments of Zellweger Syndrome is available below.

Symptoms of Zellweger Syndrome

• Enlarged liver
• Elevated iron
• Elevated copper
• Vision disturbances
• Prenatal growth failure

See full list of 82 symptoms of Zellweger Syndrome

Medical Textbooks Online about Zellweger Syndrome

Book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

Less Common Symptoms of Zellweger Syndrome

• Prenatal growth deficiency
• Glaucoma
• Nystagmus
• Cubitus valgus
• Ulnar deviation of hands

See full list of 11 occasional symptoms of Zellweger Syndrome

Causes of Zellweger Syndrome

Read more about causes of Zellweger Syndrome.

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Prognosis for Zellweger Syndrome

Prognosis for Zellweger Syndrome: Poor. Death common within 6 months.

More about prognosis of Zellweger Syndrome

Reseach about Zellweger Syndrome

Visit our research pages for current research about Zellweger Syndrome treatments.

Clinical Trials for Zellweger Syndrome

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Zellweger Syndrome include:

• Study of Bile Acids in Patients With Peroxisomal Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - chenodeoxycholic acid,cholic acid,ursodiol
• Study of Oral Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis - This study has been completed (Current: 23 Nov 2006)

Read more about Clinical Trials for Zellweger Syndrome

Statistics for Zellweger Syndrome

• Medical statistics for Zellweger Syndrome
• Prevalence and incidence statistics for Zellweger Syndrome
• Death and Mortality statistics for Zellweger Syndrome
• Society statistics for Zellweger Syndrome

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Article Excerpts about Zellweger Syndrome

Genes and Disease by the National Center for Biotechnology (Excerpt)

Zellweger syndrome is a rare hereditary disorder affecting infants, and usually results in death. (Source: Genes and Disease by the National Center for Biotechnology)

NINDS Zellweger Syndrome Information Page: NINDS (Excerpt)

Zellweger syndrome is a rare, congenital (present at birth) disorder characterized by the reduction or absence of peroxisomes (cell structures that rid the body of toxic substances) in the cells of the liver, kidneys, and brain. Zellweger syndrome is one of a group of genetic disorders called peroxisomal diseases that affect brain development and the growth of the myelin sheath, the fatty covering—which acts as an insulator—on nerve fibers in the brain. (Source: excerpt from NINDS Zellweger Syndrome Information Page: NINDS)

Definitions of Zellweger Syndrome:

Zellweger Syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Zellweger Syndrome, or a subtype of Zellweger Syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Zellweger Syndrome as a "rare disease".
Source - Orphanet